Joshua Mitchell

PhD student @ Uni of Bristol

[Joshua Mitchell @JMChem_]

@JeanGalano @SebVidalChem @AggarwalLab @NatureSynthesis @BristolChem Aha of course I didn’t block you. I’m very eager to see how you get on with this simulation.

[Joshua Mitchell @JMChem_]

@JeanGalano @SebVidalChem @AggarwalLab @NatureSynthesis @BristolChem No chance you could do it with that. Would take crazy computing time for something that big and conformationally flexible, not to mention that the error in chemical shifts is likely going to be greater than the biggest chemical shift differences between the diastereomers.

[Ewan Birney @ewanbirney]

So @JeremyFarrar asked for an "explainer thread" on Noble Prizes in Chemistry around AlphaFold and Protein design, so here goes.

[Andrew Côté @Andercot]

Superconducting magnet engineer chiming in.

This result could be very big news, and overnight revolutionize all of electronics and energy. It might not.

Here's a mental model for the non-expert to understand what's going on.

RTAPS: The good, the bad, and the ugly: 🧵

[Joshua Mitchell @JMChem_]

@NMRspectroscopy Oh right because in the bottom case the top centre is attached to two ethoxy groups so isn’t chiral, but when substituting on the ethoxy, this now makes the centre chiral so the protons are diastereotopic.

[Joshua Mitchell @JMChem_]

@That_Chemist Glad they’ve found milder conditions using purple carrots. Ultraviolet carrots were just impractical.

[Joshua Mitchell @JMChem_]

@NMRspectroscopy Some kind of tautomerism that’s favoured in one solvent over another? And this tautomerism may break some symmetry in the second case?

[Joshua Mitchell @JMChem_]

@uOttawaNMR Is this the case with 19F NMR as well?

[Joshua Mitchell @JMChem_]

When a $32 billion dollar company kill 4 employees and expose an entire community to a toxic gas, a $16 million fine really feels proportional 🤔

[Chemistry World @ChemistryWorld]

More than eight years after a major methyl mercaptan leak at a DuPont plant in La Porte, US killed four employees and injured others, the company and the head of its Insecticide Business Unit have both pleaded guilty to criminal negligence.

https://t.co/sy1wS5syqG

[nature @Nature]

In 2020, Nature endorsed Joe Biden in the US presidential election. A survey finds that viewing the endorsement did not change people’s views of the candidates, but caused some to lose confidence in Nature and in US scientists generally https://t.co/lvrgXmsrl5

[Joshua Mitchell @JMChem_]

@RWMaloneMD Ah yes that super legit paper, which writes equations with Microsoft word, has unlabelled axes on figures, doesn’t reference properly, and literally changes fonts at random throughout the paragraph. Defo a high quality publication.

[Joshua Mitchell @JMChem_]

@stkirsch Hmm, is it common for equations in papers to be formatted with Microsoft word? And to have unlabelled axes in figures? Change font in the middle of a paragraph? This is a lazy attempt at a fake paper.

[Joshua Mitchell @JMChem_]

@dasingleton I think this is why most supervisors won’t let their students work with highly toxic reagents.

[Joshua Mitchell @JMChem_]

@BretWeinstein @jordanbpeterson @HeatherEHeying The problem is your camp have claimed a variety of substances are effective against covid, most of the time with very preliminary and inconclusive data. Just because one sticks doesn’t mean that you’ve been right all along, when you’ve been wrong on far more.

[Joshua Mitchell @JMChem_]

@KRHornberger BAIB

[Joshua Mitchell @JMChem_]

This might be my favourite one.

[The Journal of Immaterial Science @JImmatSci]

A novel uranium-vanadium catalyst for the Fischer esterification.

[Joshua Mitchell @JMChem_]

Feel free to check out my latest article on antidepressant effectiveness for the Oxford Scientist! Would appreciate any feedback. https://t.co/lEWZZF0atu

[Joshua Mitchell @JMChem_]

Electrons are chiral now 🫠

[Chemistry World @ChemistryWorld]

The team was able to produce chiral poly(2-vinyl pyridine) from completely achiral 2-vinyl pyridine by electropolymerisation on a magnetic electrode

https://t.co/oz3uID98NI