Good morning #ASCO26! Later today, don’t miss Dr. Marc Hoffmann presenting “Golcadomide (GOLCA), a potential, first‑in‑class, oral CELMoD + Pola‑RCHP in patients with newly diagnosed aggressive B‑cell lymphoma (a‑BCL): Safety and 12‑month efficacy results.” It’s part of the Rapid Oral Abstract session happening in Room E450a at 1pm.
Congratulations to Jesus Gonzalez Lugo, MD, recipient of the Winn Career Development Award, a national program that supports clinicians leading community‑focused clinical research. Learn more: https://t.co/P0vlvEqGsK
Bruton Tyrosine Kinase Inhibition in Combination With Bispecific Antibodies for Richter's Syndrome: A Report of Two Cases and Mini Review. https://t.co/pmtTDM0IlF #Lymsm#CLL#Richters
Hematology Fellows
Remember this flow pattern!
APL: Promyelocytes one step more differentiated from myeloblasts and lose CD34 expression. Blasts typically CD34+, but APL CD34-/
CD13+, CD33+, CD117+, MPO+, CD34-, HLADR-
Dr. Marc Hoffmann @KUcancercenter presented Golcadomide + Rituximab in R/R NHL. Golcadomide (GOLCA), a potential, first-in-class, oral CELMoD™ agent, ± rituximab (R) in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): Phase 1/2 study extended follow-up Results Median 4L prior therapy, many CAR-T exposed / Bispecific exposed, 0.4mg Golca ORR 58% in all patients, ctDNA deep reductions even in high risk TP53mut disease. Promising data! #ASH25 #lymsm
Final analysis of ROSEWOOD 3L setting Zanubrutinib + Obinutuzumab (Z+O). ORR 70%, CR 42%, TTNT 51mo. mOS not reached. TRAE 9.8% stopped from AEs. Obinutuzumab definitely active with prior Rituximab in cFL. Patient selection is key, several good options cFL. #ASH2025#lymsm
Zanubrutinib demonstrated reduced risk of progression/death compared to ibrutinib, acalabrutinib, and bendamustine or idelalisib+rituximab. https://t.co/ojHOlqWzT3 #lymphoidneoplasia
Goodbye fellow cubicle, we anxiously await the attending office. Many hours spent here: charting, editing papers, studying, spinning the proverbial hamster wheel. Ready for the next phase of my career!
We’re in Briarcliff! Now patients have 3 locations to choose from in the Northland. Ranked in the top 1% nationwide, #KUCancerCenter offers unrivaled expertise and experience in diagnosing and treating all forms of cancer. Learn more: https://t.co/3XRkNTtDqY
Prophy dex with glofitamab (4 mg after 1st glofi & bid for 3 days after C1D8, C1D15, C2D1) with reduction in CRS from 63% in trial to 32%, all G1-2. Moving towards outpatient glofi. #18ICML#lymsm
Excited to dive into this one for some casual reading. It’s a small book so should be quick read. I’ll post my thoughts once finished :) #MedTwitter#Hematology