Jonathan S. Kingston

• Attorney • EMT • EMT at WTC on 9/11 • Autism Dad • Make sense common again.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. I've held dying hearts in my hands in the cath lab at 3 AM. And I need to tell you something that changes everything about how we prevent heart attacks.

For decades, the entire field was built on one target: lower LDL cholesterol. Statins save lives — that's settled science. But too many of my patients did everything right — took their statins, hit their numbers, lived clean — and still ended up on my table with a ruptured artery.

We were treating the smoke while the fire kept burning.
The fire is inflammation. And the evidence is now overwhelming.

The CANTOS trial proved it first — lowering inflammation independent of cholesterol reduced cardiac events. But the newer data is what keeps me up at night.

AI-enhanced CT angiography can now detect inflamed arteries by measuring changes in the fat surrounding your coronary vessels — the perivascular fat attenuation index. Higher inflammation in the fat around even one artery independently predicts cardiac death. When multiple arteries show inflammation, the risk multiplies dramatically — even in patients whose cholesterol looks perfect.

This isn't theoretical. This is measurable. Right now. On a scan you can get this month.

Low-dose colchicine — a drug that's been around for centuries for gout — is now FDA-approved specifically for reducing cardiovascular events. It works by quieting the inflammatory cascade that destabilizes the plaque sitting in your arteries. A pill that costs pennies is saving lives the statins couldn't reach.

And the next wave is already in Phase 3 trials. Ziltivekimab — an IL-6 inhibitor — targets the central inflammatory pathway driving atherosclerosis. Phase 2 data showed a 90% reduction in hsCRP. The ZEUS cardiovascular outcomes trial is enrolling now, with results expected late 2026 into 2027. If positive, anti-inflammatory therapy will become standard in managing heart disease alongside lipid-lowering. The era of inflammation-targeted cardiology is arriving.
But it goes deeper than drugs. AI is now predicting heart failure and cardiac events 5+ years before symptoms — integrating CT imaging, electronic health records, and genetic data with accuracy that jumps far beyond traditional risk calculators.

And polygenic risk scores — a simple genetic test that flags inherited cardiovascular risk — are now formally recognized as a risk-enhancing factor in the 2026 ACC/AHA guidelines. A single blood draw can reveal risk that's been silently building since birth. Decades before the first chest pain.

Here's what this means for you right now — today:
Ask your doctor for a high-sensitivity CRP test. It's cheap, routine, and measures the systemic inflammation that standard cholesterol panels completely miss. You can have perfect LDL and inflamed arteries that are quietly preparing to rupture.
If your hsCRP is elevated, discuss low-dose colchicine with your physician. It's FDA-approved for exactly this.
Push for a coronary CT angiography with AI plaque and inflammation analysis if you have risk factors. This isn't the stress test your parents got. This is 3D visualization of your actual arteries — with AI quantifying not just how much plaque you have, but what kind it is and whether the surrounding tissue is inflamed.
Consider polygenic risk score testing — especially with a family history of early heart disease. It's now guideline-supported.

And the foundation that never changes: move daily, eat real food, sleep 7-9 hours, manage stress, and know your numbers — ApoB, Lp(a), hsCRP, fasting insulin.
I left Iran as a child with nothing. I rebuilt everything in a country that gave me the freedom to become a physician. I've spent twenty years watching patients get second chances.

The ones who haunt me aren't the ones who died on my table. They're the ones who survived but never acted on what the science was telling them — years before the event that didn't have to happen.

You can have perfect cholesterol and still have a heart attack. Inflammation plus genetics can drive plaque rupture in arteries that look "fine" on a standard panel.
The myth that normal cholesterol means you're safe has cost more lives than I can count.

We now have the tools to detect the fire — not just the smoke. AI to see it. Genetics to predict it. Drugs to quiet it. And the ancient basics — movement, real food, sleep, purpose — to prevent it from starting.

Prevention is the new cure. And the science to make it real is no longer coming.
It's here.

[Chef Andrew Gruel @ChefGruel]

Landed in NYC at 2:30 am, had to grab a pizza. Even the late night pizza is better than anything in LA.

[Jonathan S. Kingston @JS_Kingston]

@xAviation Live look at me on a Friday afternoon

[Christina Pushaw 🐊 🇺🇸 @ChristinaPushaw]

Ah yes, the Soviet Union. Famous for cutting taxes and protecting private property rights.

[Jonathan S. Kingston @JS_Kingston]

Take a moment away from stress to listen to this beautiful cover: Duran Duran - Come Undone (Cover) https://t.co/876oOwEdrY via @YouTube

[Sahil Bloom @SahilBloom]

I’m convinced that no matter how you choose to live, people will tell you that you’re doing it wrong. Wrong priorities. Wrong work. Wrong relationships. Wrong whatever. Your entire life will change the moment you learn to smile, nod, and ignore every single one of them.

[Elon Musk @elonmusk]

@IterIntellectus Harnessing even a millionth of the Sun’s power, which is extremely difficult, results in an economic value far more than a million times than that of Earth’s current entire economy

[Israel War Room @IsraelWarRoom]

The IDF intercepted three rockets launched from Lebanon at Israeli communities.

Hezbollah and its terror partners have not stopped trying to murder Israelis.

[David Keyes @DavidMKeyes]

I'M ORDERING A TON OF PIZZAS TO THE PENTAGON. TAKE SHELTER.

[David Keyes @DavidMKeyes]

🚨🚨 Iran asks if they can sign final deal with blood of Americans and Israelis they killed over the decades

[David Keyes @DavidMKeyes]

🚨🚨 Iran deal has been agreed to! Only issue that remains is agreeing that it's been agreed to.

[Jonathan S. Kingston @JS_Kingston]

Never leaving X

[David Keyes @DavidMKeyes]

🚨🚨 Iran deal NEARLY finalized. Last sticking points are Iran's insistence on destroying West, killing all infidels and imposing Islam on the world. Fingers crossed!

[Jonathan S. Kingston @JS_Kingston]

@JimmysSeafood @interesting_aIl Time for a drone which detects speakerphone use in restaurants & projects a clown hat onto the offender.

[𝗦𝗵𝗼𝘄 𝗠𝗲 𝗧𝗵𝗲 𝗗𝗮𝘁𝗮 @txsalth2o]

In an airport lounge bathroom lady on the can answers her phone on speaker:

“How was the wedding?”
“It was beautiful.”

Me in the next stall: “I’m so glad it was beautiful tell me more!”

Goes off speaker, mutters “bitch”leaves the bathroom.

We’ve got to start having fun with those losers.

[Jonathan S. Kingston @JS_Kingston]

🛑 Staten Island Dock Explosion Video

[Jonathan S. Kingston @JS_Kingston]

@caroljsroth Just here wondering how many votes Sam Altman got for Supreme Leader of The World.

[Jonathan S. Kingston @JS_Kingston]

🛑 Staten Island Dock Explosion Video

[Jonathan S. Kingston @JS_Kingston]

@NYCMayor I was JUST wondering about delivery trucks idling while cleaning the flood caused by inadequate NYC sewers, after driving on the pothole infested minefields which pass for NYC streets.

[Jonathan S. Kingston @JS_Kingston]

@ishapiro @EYakoby I’m old enough to remember when the NY Times Editorial Page & front page were distinct from each other.

[Jonathan S. Kingston @JS_Kingston]

Give the customers the option to buy out the machine.

[Chase Passive Income @chasedownleads]

The train is about to hit 5 loyal customers of your vending machine

You can divert it, but doing so would destroy the vending machine and your source of passive income

What do you do?