Jackrel Lab Members

Official student-run #ScienceTwitter of the Jackrel Lab at WashU/STL. Studying the biochemistry of protein misfolding, chaperones, & disaggregases

[Jackrel Lab Members @JackrelLab]

We are excited to share our paper on Matrin-3 phase separation that is out now!

[Molecular Cell @MolecularCell]

Online Now: Matrin-3 forms spherical and wormlike assemblies that are modulated by RNA binding and ALS/FTD-associated mutations https://t.co/VKDkwPI06D

[Jai Rudra he/him @JaiRudra4]

Grateful for a 5-yr R01 award from the National Institute on Aging for developing vaccines against neurodegenerative diseases. Thanks to collaborations with @JackrelLab and support from @WashUBME @WashUengineers

[Jackrel Lab Members @JackrelLab]

@ScienceofPD Thanks for sharing our work @ScienceofPD 😍

[The Science of Parkinson's @ScienceofPD]

Interesting: New paper from @JackrelLab & colleagues reports PDZ serine protease HTRA1 disaggregates #Parkinsons-associated α-synuclein amyloid fibrils & converts them into non-toxic/seeding incompetent species; Future = small molecule HTRA1 modulators
https://t.co/qRyGyqixCr

[Jackrel Lab Members @JackrelLab]

Check out the paper now to get all the juicy🧃details! https://t.co/HHfzK9G5i0

[Jackrel Lab Members @JackrelLab]

📢We are excited to share that our paper on HTRA1 remodeling of alpha-synuclein is available now online with @NatureComms! Check out our main findings below 👇

[Jackrel Lab Members @JackrelLab]

Big shout out 🗣️ to the team that made it all possible: Sheng Chen, @AnuradhikaP, Braxton Bell, Joey Fritsche, Hector Palacios, Maurie Balch, @MacySprunger, @matthewkhoward, Jeremy Ryan, Jessica Haines, @gjpattij, @GusDavisLab, & Meredith Jackrel!

[Jackrel Lab Members @JackrelLab]

So happy for and proud of our favorite boss Dr. Jackrel! Newest tenured prof in @WashUChem!

[Jackrel Lab Members @JackrelLab]

Yesterday Sheng (Andy) Chen defended his dissertation like a star ⭐️ We are proud of all he has accomplished during his graduate studies! Congrats Dr. Chen!

[Jackrel Lab Members @JackrelLab]

Yesterday we celebrated @MacySprunger's dissertation defense! 🎉She is the first graduate student to defend from the lab and we are very proud of all she has accomplished during her graduate studies!🧬

[Jackrel Lab Members @JackrelLab]

@SHENGCH86713022 @AnuradhikaP @BalchMaurie @MacySprunger @matthewkhoward @gjpattij @GusDavisLab

[Jackrel Lab Members @JackrelLab]

It is the first look at one of our big projects in the lab! We have been investigating how human serine protease HTRA1 can prevent and disaggregate alpha-synuclein amyloid! You can check out the preprint now 👇👇https://t.co/HoM4ugaSTP