Jacob Jordan

Biophysics PhD Candidate @ Berkeley | Native Mass Spectrometry | Evan R. Williams Research Group

[Jacob Jordan @Jacobiomics]

Happy to announce that we have a new publication out in @an_chem using charge detection mass spectrometry to characterize the size and shape of protein oligomers formed after heating with and without aggregation inhibitors. Check it out here: https://t.co/4vISUIw76p

[Jacob Jordan @Jacobiomics]

@sciqst And as far as surprising insights go, we see a large structural rearrangement from an elongated to a compact structure that occurs at both the mAb pentamer and the decamer. I think this compaction occurring exactly at units of 5 is really interesting! More details in the paper.

[Jacob Jordan @Jacobiomics]

We have a new article out in @J_A_C_S! In a fruitful collaboration with @Merck scientists, we compared CDMS and other conventional techniques to investigate the size and shape of mAb aggregates. Check it out here if you like mAbs, native MS, or cats:
https://t.co/ISJ8fqVojo

[Jacob Jordan @Jacobiomics]

@sciqst Hi Raffaele, we didn't directly compare sensitivity in this study, but we believe that CDMS gives the most accurate picture of the solution-phase abundance of higher order aggregates of the techniques sampled here. (1/2)

[J. Am. Chem. Soc. @J_A_C_S]

Charge Detection Mass Spec Reveals Conformational Heterogeneity in Megadalton-Sized Monoclonal Antibody Aggregates | JACS @UCBerkeley @UCB_Chemistry #MAssSpec #Conformational #Heterogeneity #Megadalton #Monoclonal #Antibody https://t.co/JA9KGYKkmX

[Dr. Kim Greis @kimgreis]

Congrats @Jacobiomics! I like the ToC figure!

[Jacob Jordan @Jacobiomics]

@kimgreis Thanks Kim! Had some fun with this TOC graphic :)

[Stacy Malaker @StacyMalaker]

Have you ever wondered how often N- 🟦and O- 🟨glycans modify the same peptide? We did too! Check out our new preprint online now, spearheaded by @joann_chong with help from @VRAdoesMS, @keira_Erol, and @TarynMLucas! 🧵👇

[Lindsey Ulmer @lindseyulmer1]

I am excited to share that my paper on identifying residue-level BPA crosslinks is out! @bushresearch

https://t.co/A6G1RoDKN6

[Jacob Jordan @Jacobiomics]

Excited that our most recent paper is out now in ACS Nano. We show that CDMS is a promising tool for the characterization of the diameter and surface properties of nanoparticles. Even information about nanoparticle densities can be obtained. Link here:
https://t.co/WqqcfIY13p

[Jacob Jordan @Jacobiomics]

#ASMS2024 Interested in ambient ionization/DESI/DART techniques or applications? Want to celebrate the 20th anniversary of the development of DART/DESI? Want to sit and drink a beer while listening to nice talks? Then come by the ambient ionization workshop tonight (Ballroom DE)!

[Jacob Jordan @Jacobiomics]

Interested in new methods of studying protein aggregation using mass spectrometry? Come by my talk tomorrow AM at #ASMS2024 if so. Details attached!

[Dr Marc VG (now a dad!) @marcwvg]

New pre-print alert: Excited to share our latest work on the unique relationship between Antarctic bacteria and their phages 🦠🇦🇶
Novel cas sequences, divergent evolutionary histories and more with @Thuls_M
Please read it here: https://t.co/iAIkSXc292

[Jacob Jordan @Jacobiomics]

The Evan R. Williams group is presenting loads of work at #ASMS2024. Stop by any of our talks or posters to learn more about #NativeMS, #CDMS, or #Microdroplets!

[Jacob Jordan @Jacobiomics]

Excited to share that we have a new paper out in @analystrsc showing that the localized heating of laser-heated ESI can be used to acquire melting curves for aggregation-prone proteins and their ligand-bound forms simultaneously! Check it out here:

https://t.co/x6aBtPtHkM

[Michael Marty @michaeltmarty]

New set of #MassSpecCodingClub modules posted: https://t.co/7A5OvYSDJG

Free videos to learn coding for MS applications. Take a look and let me know via the discussion what ideas you have for future projects.

[Bleiholder Group @BleiholderFSU]

(1/2) Please RT. Our lab is organizing a Spring Workshop on Protein Structure Elucidation with Ion Mobility Spectrometry/Mass Spectrometry on March 11-13, 2024.

Topics: TIMS/MS, Tandem-TIMS/MS, PSA, and SRA.

https://t.co/9LlNcnBfvl

@asmsnews @FemalesInMS @NSF

[BioMassSpec @realBioMassSpec]

On the Chemistry of Aqueous Ammonium Acetate Droplets during Native Electrospray Ionization Mass Spectrometry #AC https://t.co/hrQqpzMKOP

[Jacob Jordan @Jacobiomics]

Excited to share that our work on corona discharge at the tip of submicron nanoelectrospray emitters has made the cover of @J_ASMS!

https://t.co/yn9mMyOuHn

[Jacob Jordan @Jacobiomics]

Fellow #teammassspec ambient ionization enthusiasts, @AL_Anyin has formed a LinkedIn group! If you are interested in hearing the latest news about the annual Ambient Ionization workshop at #ASMS2024, and recent developments in the field, please join!

https://t.co/i8fy8roHXz