Jakob Langer

PhD student @TheLutolfLab @EPFL

[Matthias Lutolf @TheLutolfLab]

Bioengineered GI organoids just got an upgrade! Our new Transgel system combines 3D complexity with bilateral accessibility & remarkable observability, enabling advanced studies on tissue dynamics, stem cell niches, and host-pathogen interactions.🔬
👉 https://t.co/OeiSs0ehdO

[Angewandte Chemie @angew_chem]

A Site-Specific #ClickChemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168 (Beat Fierz and co-workers) @_paulinefranz, @Beatfierz, @EPFL_en #openaccess https://t.co/TVjWOJuXbB

[Tania Hübscher @TaniaHubscher]

Thymic epithelial organoids mediate T-cell development https://t.co/OoxNK4Poa5
Our story on developing a new model to study the #thymus is now published @Development!
We identified culture conditions where single sorted thymic epithelial cells develop into #organoids.

[Nature Reviews Genetics @NatureRevGenet]

Also in this issue, a #ToolsoftheTrade by @LFranciscoLM & @TheLutolfLab @EPFL:
Mini-colons unlock tumour development outside the body https://t.co/C5QOJFRrlJ #NRGToT

[Nature Biotechnology @NatureBiotech]

Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity https://t.co/elhMQS9o6O

[Matthias Lutolf @TheLutolfLab]

Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication: https://t.co/Uck4EyBXeK

[L. Francisco Lorenzo Martín @LFranciscoLM]

Thrilled to share our latest work in @NatureBiotech! Discover how tissue-engineered mini-colons can advance our understanding of patient-specific colorectal cancer biology:

[Matthias Lutolf @TheLutolfLab]

This work was spearheaded by the hugely talented @LFranciscoLM and @TaniaHubscher, and supported by our collaborators Amber Bowler, @NicoBroguiere, @JakobJLanger, Lucie Tillard, @mike_nikolaev, and @isrec_radtke. Thank you all!!

[Matthias Lutolf @TheLutolfLab]

This opens up exciting prospects for cancer research as it provides a powerful tool for mechanistic studies and testing of potential therapies, especially when applied to human patient-derived organoids - stay tuned for follow-up work also from the @IHB_Research!

[Matthias Lutolf @TheLutolfLab]

Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling https://t.co/N619EGEFgc. Let’s have a quick look!

[Matthias Lutolf @TheLutolfLab]

These organoids maintain thymus functionality and mediate physiological T cell development upon reaggregation with T cell progenitors. Huge thanks to all collaborators @LFranciscoLM, @JakobJLanger, Thomas Bartlott, Lucie Tillard, Paul Rouse, Clare Blackburn and Georg Holländer!

[Matthias Lutolf @TheLutolfLab]

Excited to share our latest preprint on human mini-guts! https://t.co/rqQctWaDui Great work by @olga_mitrofan 🙌🎉

[Matthias Lutolf @TheLutolfLab]

Happy to see JiSoo Park’s work on mouse neural tube organoids published https://t.co/rZyDHby1fk 👏🎉!! Not quite a #SyntheticEmbryo… but still impressive display of the self-organization capacity of stem cells. Check out the neural crest cells that emerge from these organoids!

[Matthias Lutolf @TheLutolfLab]

Exciting collaboration with the @PetrovaLab, thanks for involving us! Great potential for modelling nutrition with next-gen organoids.

[Simon Duerr @simonduerr]

Happy to present our new preprint on a deep-learning based method for rapid localization of transition metal ions in protein structures: Metal3D. Work done with @andrea_levy and @lcbc_epfl 1/6 https://t.co/cv1xrNEaAQ

[Jakob Langer @JakobJLanger]

I enjoyed my first presentation @VIBLifeSciences #VIBTraining in Leuven today! I’m grateful for the opportunity to share some insights into our culture model together with @MatthiasLutolf and enjoyed exciting talks!

[VIB @VIBLifeSciences]

During the first session, we had inspiring talks by Arnold Kriegstein @Kriegsteinlab, Madeline Andrews @Andrews_MG, Matthias Lutolf, and Jakob Langer
@TheLutolfLab. Looking forward to hearing more!

Read the program here
👉 https://t.co/DY5O9sErQg