Jim

[Jim @JamesMclaw70633]

@Jonatha44409099 You sure don’t look old

[Jim @JamesMclaw70633]

@tinaxkitsune Missed you

[Jim @JamesMclaw70633]

@BioBoyScout Arrowhead has slightly more patients with prior history of AP than Ionis had in Core study and this is where the majority of events occurred.

[Jim @JamesMclaw70633]

@3IDWarrant Huge amounts of data coming soon.

[Jim @JamesMclaw70633]

@BioBoyScout @MykeC382023 Will be interesting to see if we get a bump( Like WVE Inhbe) on nexts week Biogen presentation

[Jim @JamesMclaw70633]

@welshinator Any thoughts on if SRPT could get accelerated approval on RNAI muscle drugs if data is better than competition?

[Jim @JamesMclaw70633]

@BioBoyScout If after the data drops this fall would the large institutional owners not have the say if a buyout offer came in around 30 to 35B?

[Jim @JamesMclaw70633]

@BioBoyScout @j6_a12 Thanks. Hoping getting into the deep brain region at much higher level will be game changing.

[Jim @JamesMclaw70633]

@BioBoyScout @j6_a12 Any chance at all they could get accelerated approval off a ph2 trial if efficacy is a good bit better than Biogen drug?

[Jim @JamesMclaw70633]

@stevejones777 So sorry for your loss. Bless you

[Jim @JamesMclaw70633]

@amethystangel80 @stevejones777 So sorry for your loss. I hope you can know it was a blessing to have them in your life and hope it is a comfort to you to know you have given them a good life and will see them again.

[Jim @JamesMclaw70633]

@PopcornPost_ Mississippi Burning

[Jim @JamesMclaw70633]

@AZ_Brittney Kristen is as good as it gets in her business. Trump couldn’t take it.

[Jim @JamesMclaw70633]

@amethystangel80 @DogLovers03 Know what you mean. I have lost two Rotties and on my third one now. Wonderful dogs! Always miss them.

[Jim @JamesMclaw70633]

@FeelGoodAnimals Nothing like a Rottie.

[Jim @JamesMclaw70633]

@BioBoyScout We have 5 data readouts between August and end of year. The $SRPT muscle readout might take another month or so. Hopefully will generate buyout talk.

[Jim @JamesMclaw70633]

@BioBoyScout Question: Should tau protein reduction be expected to be the same in healthy volunteers as in Alzheimer’s patients with ARO MAPT

[Jim @JamesMclaw70633]

@RNAiAnalyst Will be interesting to see $ARWR results with Subq delivery. Same target.

[Jim @JamesMclaw70633]

@RNAiAnalyst Considering $ARWR is only one with Subq delivery at present I would say them. Reported more positive preclinical data at Tides yesterday. Reaching deep brain regions IT is not.

[Jim @JamesMclaw70633]

@aroog1278 Very!