James Gallagher

Dynamic catalysis and nonequilibrium chemistry.
Postdoc @Toste_Group at @UCBerkeley, PhD @ProfDaveLeigh at @OfficialUoM.

[James Gallagher @James_Gall_]

Out now in @NatureSynthesis, we drive an endergonic Diels-Alder reaction energetically uphill by chemical fuelling. Reminiscent of anabolism in biology, we hope that an understanding of endergonic synthesis will help expand the chemist's toolbox.
https://t.co/oxSlYCLkZB

[James Gallagher @James_Gall_]

Find the thread on the other place. User: jamesgallagher

[James Gallagher @James_Gall_]

In biology, molecular machines exist to perform useful functions. Artificial molecular machines now move in the same way as those in biology, but they do not yet perform tasks. Out now in @Chem_CP , a guide to task performance in molecular machinery.
https://t.co/yZvJGFIZ0V

[James Gallagher @James_Gall_]

@EPenocchio @DeanAstumian Cool! Ofc Hammond not always relevant, but it nicely shows that kinetic asymmetry /can/ be a function of the power stroke. So "x doesn't matter y does" is not very satisfying when y = f(x)!

[James Gallagher @James_Gall_]

@DeanAstumian An interaction that significantly lowers an activation barrier will also significantly lower the energy of the ground state (given Hammond). Perhaps the binary of kinetic asymmetry vs. power stroke is not useful if in many cases one depends on the other.

[James Gallagher @James_Gall_]

@DeanAstumian been thinking for a while: Given the Hammond postulate, is it chemically realistic to have very large kinetic asymmetry and NOT have a power stroke in the same direction. In other words, is it chemically realistic to "switch the kinetic asymmetry and keep power stroke the same"?

[James Gallagher @James_Gall_]

@RSC_MASC much appreciated!

[RSC_MASC @RSC_MASC]

Many excellent nominations were received, and the judging panel decided to award two Highly Commended awards to Lei Chen (University of Manchester, De Bo group) and James Gallagher (University of Manchester, Leigh group). Congratulations Lei and James!

[Chem @Chem_CP]

Online now: Out-of-equilibrium compartments: Thinking inside the box https://t.co/ss6cyT3Gw0

[James Gallagher @James_Gall_]

A pleasure to Preview recent work by @EPenocchio, @DeanAstumian and @giuliosflask for @Chem_CP. Life is defined by its compartments, find out how 'thinking inside the box' helps us to understand nonequilibrium systems here:
https://t.co/HEknoRY43G
https://t.co/aLkTC7h1NH

[James Gallagher @James_Gall_]

@FieldenStephen @royalsociety @UoBChemistry congrats steve!

[Nature Synthesis @NatureSynthesis]

June issue live🥳
Mirror-image cyclodextrins
Endergonic synthesis
On-liquid-gallium surface synthesis
Isolation of a pentadienyl-type radical
In situ generation of reactive (di)gallenes
(Continued)
https://t.co/FP238oWZUd

[Ben Roberts 🇪🇺 @benjamino_acid]

Finally, after 5 years working on it with @StefanBorsley and @ProfDaveLeigh, here is our review on ratchet mechanisms in molecular machines and beyond https://t.co/X8jI9HGNzR. This started out as the intro to my report for my first year of PhD

[Stefan Borsley @StefanBorsley]

Five years in the making with @benjamino_acid and @ProfDaveLeigh! Out now in @angew_chem, find out how to give chemistry direction with our comprehensive review on Molecular Ratchets: https://t.co/3XP62qCi3r

A brief description in the tread below.

[Nature Synthesis @NatureSynthesis]

Now online:

News & Views on the Article by @enzoolivieri4 @James_Gall_ @AlexBetts95 @Toufic_Mrad @ProfDaveLeigh at @UoMChemistry

https://t.co/83F2KFw3gq

Synthesis goes uphill by Michele Stasi, Héctor Soria-Carrera & Job Boekhoven @BoekhovenLab

https://t.co/s40C91iyQI ($)

[Ben Roberts 🇪🇺 @benjamino_acid]

Very happy to share the first article from my postdoc with @leonard_prins, "A Minimalistic Covalent Bond-Forming Chemical Reaction Cycle that Consumes Adenosine Diphosphate". Thanks to our coauthors Tommaso Marchetti (@RealTommyMarch) and Diego Frezzato https://t.co/OFZOXHRA2Z

[Chemistry World @ChemistryWorld]

Taking inspiration from synthetic biology and using a ratchet mechanism to drive the transformation, chemists have reported a rare instance of a spontaneous, energetically unfavourable reaction powered by a chemical fuel.
https://t.co/jts6RWKwBY

[James Gallagher @James_Gall_]

@DeanAstumian thanks Dean, appreciate it!

[James Gallagher @James_Gall_]

@MoranLabChem @NatureSynthesis Thanks Joseph!

[James Gallagher @James_Gall_]

Out now in @NatureSynthesis, we drive an endergonic Diels-Alder reaction energetically uphill by chemical fuelling. Reminiscent of anabolism in biology, we hope that an understanding of endergonic synthesis will help expand the chemist's toolbox.
https://t.co/oxSlYCLkZB

[James Gallagher @James_Gall_]

@EPenocchio @enzoolivieri4 @AlexBetts95 @Toufic_Mrad @ProfDaveLeigh Thanks Emanuele, and made all the better with yours and @benjamino_acid's input!

[Nature Synthesis @NatureSynthesis]

Now online and open access:

Article by @enzoolivieri4 @James_Gall_ @AlexBetts95 @Toufic_Mrad @ProfDaveLeigh at @UoMChemistry

Endergonic synthesis driven by chemical fuelling

https://t.co/83F2KFvvqS