Out now in @NatureSynthesis, we drive an endergonic Diels-Alder reaction energetically uphill by chemical fuelling. Reminiscent of anabolism in biology, we hope that an understanding of endergonic synthesis will help expand the chemist's toolbox.
https://t.co/oxSlYCLkZB
In biology, molecular machines exist to perform useful functions. Artificial molecular machines now move in the same way as those in biology, but they do not yet perform tasks. Out now in @Chem_CP , a guide to task performance in molecular machinery.
https://t.co/yZvJGFIZ0V
@EPenocchio @DeanAstumian Cool! Ofc Hammond not always relevant, but it nicely shows that kinetic asymmetry /can/ be a function of the power stroke. So "x doesn't matter y does" is not very satisfying when y = f(x)!
@DeanAstumian An interaction that significantly lowers an activation barrier will also significantly lower the energy of the ground state (given Hammond). Perhaps the binary of kinetic asymmetry vs. power stroke is not useful if in many cases one depends on the other.
@DeanAstumian been thinking for a while: Given the Hammond postulate, is it chemically realistic to have very large kinetic asymmetry and NOT have a power stroke in the same direction. In other words, is it chemically realistic to "switch the kinetic asymmetry and keep power stroke the same"?
Many excellent nominations were received, and the judging panel decided to award two Highly Commended awards to Lei Chen (University of Manchester, De Bo group) and James Gallagher (University of Manchester, Leigh group). Congratulations Lei and James!
A pleasure to Preview recent work by @EPenocchio, @DeanAstumian and @giuliosflask for @Chem_CP. Life is defined by its compartments, find out how 'thinking inside the box' helps us to understand nonequilibrium systems here:
https://t.co/HEknoRY43G
https://t.co/aLkTC7h1NH
June issue live🥳
Mirror-image cyclodextrins
Endergonic synthesis
On-liquid-gallium surface synthesis
Isolation of a pentadienyl-type radical
In situ generation of reactive (di)gallenes
(Continued)
https://t.co/FP238oWZUd
Finally, after 5 years working on it with @StefanBorsley and @ProfDaveLeigh, here is our review on ratchet mechanisms in molecular machines and beyond https://t.co/X8jI9HGNzR. This started out as the intro to my report for my first year of PhD
Five years in the making with @benjamino_acid and @ProfDaveLeigh! Out now in @angew_chem, find out how to give chemistry direction with our comprehensive review on Molecular Ratchets: https://t.co/3XP62qCi3r
A brief description in the tread below.
Very happy to share the first article from my postdoc with @leonard_prins, "A Minimalistic Covalent Bond-Forming Chemical Reaction Cycle that Consumes Adenosine Diphosphate". Thanks to our coauthors Tommaso Marchetti (@RealTommyMarch) and Diego Frezzato https://t.co/OFZOXHRA2Z
Taking inspiration from synthetic biology and using a ratchet mechanism to drive the transformation, chemists have reported a rare instance of a spontaneous, energetically unfavourable reaction powered by a chemical fuel.
https://t.co/jts6RWKwBY
Out now in @NatureSynthesis, we drive an endergonic Diels-Alder reaction energetically uphill by chemical fuelling. Reminiscent of anabolism in biology, we hope that an understanding of endergonic synthesis will help expand the chemist's toolbox.
https://t.co/oxSlYCLkZB