Jamie J. Manning

GPCR Pharmacology | Postdoc in @Javitchlab @Columbia | PhD @Otago

[Jamie J. Manning @JamieManning_]

Congratulations to Hao, Qing, and all other authors! Very happy to have played my small part in this work.

[nature @Nature]

Nature research paper: Promiscuous G-protein activation by the calcium-sensing receptor https://t.co/o383JJKt0q

[Jamie J. Manning @JamieManning_]

@lcdsmyth @Nature It is, come visit and present your work!

[St. Jude Research @StJudeResearch]

We are investing $13M toward a new research collaboration with scientists @DukeMedSchool, @ColumbiaMed & @Stanford to expand the collective understanding of G protein-coupled receptors (GPCR), which are vital proteins that impact human health and disease. https://t.co/OMzo3pGgJu

[Jamie J. Manning @JamieManning_]

@NicoleAPerry1 October nights > October mornings

[JCIM & JCTC Journals @JCIM_JCTC]

A Novel “Activation Switch” Motif Common to All Aminergic Receptors #GPCR
https://t.co/IFtLWNgjh4
@JamieManning_ @JavitchLab
#JCIM Vol63 Issue16 #Review

[Jamie J. Manning @JamieManning_]

Great symposium with excellent speakers, posters, discussion, and venue!

[Dr. Nicki Perry-Hauser @NicoleAPerry1]

Day 1 was wonderful! Congrats to the GRS speakers and discussion leaders. Ready for Day 2!

[Jamie J. Manning @JamieManning_]

Excited to attend!

[Dr. Nicki Perry-Hauser @NicoleAPerry1]

The schedule for the GRS in Molecular Pharmacology is live! https://t.co/tLcUiur1Z5 Please check it out - @BenderSci and I are very excited. Also, if you would like to contribute financially to this event, please use the following link: https://t.co/I3ksZ1Zcbf

[Dr. Nicki Perry-Hauser @NicoleAPerry1]

The @JavitchLab is looking for a new lab manager! https://t.co/lTTKg99r8G

[Dr. Nicki Perry-Hauser @NicoleAPerry1]

Attention GPCR researchers! This year the GRS/GRC in Molecular Pharmacology will be held from June 10th-16th at Les Diablerets Conference Center in Switzerland. @BenderSci and I are Co-chairs for the Gordon Research Seminar that is dedicated to early-career scientists!

[Jamie J. Manning @JamieManning_]

@VDieriks Thanks vic! It’s going well, exciting stuff!

[Jamie J. Manning @JamieManning_]

Some of the work from my PhD is now available! We searched for arrestin2/3 binding motifs in the CB1 c-terminus and found: 1. The pxxp motif isn’t critical for CB1. 2. Both arrestin subtypes require the same sites. 3. There are two functionally distinct phosphorylation clusters.

[British Journal of Pharmacology (BJP) @BrJPharmacol]

Very nice exploration of the #CB1 phosphorylation sites for #arrestin interaction

Authors investigated how different serine/threonine residues within the #CB1 C-terminus affect arrestin2/3 translocation in response to MDMB-FUBINACA

Find out more here: https://t.co/SQylUXBqIS

[Wesley B. Asher @WesleyBAsher]

Our paper “GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision” is out today! We use single-molecule FRET imaging and other biophysical approaches to explore the structural dynamics of β-arrestin1 activation upon binding GPCRs. (1/6)

[Dr Mark Connor @markfrommacq]

Putative SCs MEPIRAPIM, 5F-BEPIRAPIM (NNL-2), and Their Analogues Are T-Type Calcium Channel (CaV3) Inhibitors https://t.co/hTaf0NQVzz
Cool work reporting more (non)-SCRA as modulators of T-type Ca channels ... plenty of potential in a number of different disease states 1/4

[Jamie J. Manning @JamieManning_]

1st annual #ECIGPCR conference so far so good - interesting work being presented. Thanks @NicoleAPerry1 and committee for organising, definitely worth getting up at 1am for!
If anyone wants to know about CB1 motifs for Arrestin binding come see poster 85.

[Michel Bouvier @Michel_Bouvier]

Happy to see our review on BRET-based biosensors monitoring GPCR activation and pathway selectivity in Current Opinion in Structural Biology alongside many other interesting papers.
https://t.co/4RhwaClvaj