Jan Mathony

Scientist with a passion for Synbio | Protein engineering | Optogenetics

[Jan Mathony @JanMathony]

@Leti_RM_96 Thanks leti :)

[Jan Mathony @JanMathony]

Publication alert: Our paper on domain insertion predictions in proteins is now out in @naturemethods in its final form: https://t.co/z97Qpwb1uS
Also check out the nice perspective by Noah Holzleitner and Julian Grünewald: https://t.co/5FK6AkqGiv

[Nature Methods @naturemethods]

ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins.

https://t.co/BuRrSj64Hw

[Martin Pacesa @MartinPacesa]

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

[Nicholas Southern @NeurosciNikolai]

Excited to share my main PhD work is finally out! 🥳

We built a phage-assisted evolution platform to evolve allosteric protein switches (POGO-PANCE) and introduce cumulative, targeted mutations/Indels (RAMPhaGE)!

See how we evolved strong, light-switchable AraC variants:

[David R. Liu @davidrliu]

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share!
https://t.co/cyVZpAwJiq

[bioRxiv Synthetic Biology @bioRxiv_synbio]

Modular Engineering of Thermo-Responsive Allosteric Proteins https://t.co/fawS78JBoU #biorxiv_synbio

[Jan Mathony @JanMathony]

Huge congrats to all authors, especially to co-first authors Kira Hoffmann and Ann-Sophie Kroell, who did an outstanding job!

[Jan Mathony @JanMathony]

New paper alert! We introduce the modular allosteric thermo-control of protein activity.
https://t.co/OksXdrEcjp

[Jan Mathony @JanMathony]

In line with recent work by Bugaj and colleagues, who pioneered the thermal programming of protein localization and cell signaling using BcLOV4 (https://t.co/JD4asIZ57u...), our result highlight LOV domains as versatile thermoreceptors.

[Ben Kleinstiver @BKleinstiver]

In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️
@RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed
https://t.co/oNtG93uXCl

[Jan Mathony @JanMathony]

@CeMM_News @BockLab It was a pleasure to meet all of you and discuss science! Many thanks again for the invitation.

[Johannes Gräff @GraeffJohannes]

We are looking for a new PhD student to join our lab of Neuroepigenetics at EPFL! Interested in deciphering the epigenetic mechanisms of memory formation, storage and change?🧠🧬Check out the specifics here: https://t.co/Oe8U6kCX6p

[Jan Mathony @JanMathony]

We have an exciting new PhD opportunity!
If you are fascinated by proteins and their dynamics and want to engineer them to develop new molecular tools: apply now!
We are a young and dynamic team combining state of the art laboratory and bioinformatics approaches.
Please share.

[Jan Mathony @JanMathony]

@RodriSenovilla @PhyloBrain @MargaridaMCM @AinaCastellanos @jlferran @AchucarroGlia @kaessmannlab Congrats Rodrigo!! That's great news :)

[Kaessmann Lab @kaessmannlab]

So excited to announce that our study on the development and evolution of pallial cell types and structures in birds led by @BassiZaremba is now out in @ScienceMagazine!
https://t.co/Q4wOp1OKDl

PS: this is our last post here – please follow us to where the sky is blue!

[Fernando García-Moreno @PhyloBrain]

Conducted by @RuedaEneritz, we have seen that pallial neurons are generated in different regions and stages of the embryonic brain🐣🦎🐀: pallial neurons and circuits have evolved separately. Evolutionary CONVERGENCE of neurons and circuits!
https://t.co/2ctu2n8tkk