Jan Michler

[Andreas E. Moor @AndreasMoor]

Super excited about this new preprint of the lab 🚀🚀. Congrats to @cocoborrelli and all coauthors. Our research delves into the world of tumor-hepatocyte interactions, spotlighting #PlexinB2 as a key player in regulating liver metastasis.

[Jan Michler @JanMichler]

@moorlab @ZurbuchenY Special thanks to @ZurbuchenY for a great collaboration and to all the other collaborators from both labs!

[MoorLab @moorlab]

New research from our collaboration with the Boyman lab at @UZH_ch now published in @NatImmunol: https://t.co/nSkmwNVMEx! Check it out to learn about memory B cell plasticity, longitudinal tracking of B cell clones and much more performed by @ZurbuchenY and @JanMichler! Digest:🧵

[YZurbuchen @ZurbuchenY]

Our paper on the memory B cell response to SARS-CoV-2 infection is out! It's been a great collaboration with @JanMichler and the @moorlab team with many exciting discussions, some depressing evenings when the machines failed us, but more than worth it!

[D-BSSE, ETH Zurich @ETH_BSSE]

Congratulations, Andreas @AndreasMoor, on being elected member of the Young Investigator Programme of the European Molecular Biology Organisation @EMBO_YIP!
> https://t.co/9y6TK2PIVL @ETH_en

[MoorLab @moorlab]

We are excited to share our new preprint about our development of a new #spatialTranscriptomics method (sphere-sequencing) to unveil local tissue microenvironments at single cell resolution! https://t.co/Vfg0AGccIp
See below the #tweetorial from our very own @handlerkristina 👩‍🔬

[Andreas E. Moor @AndreasMoor]

Please retweet: new tenure-track assistant prof position at @ETH_BSSE @ETH_en. Great place to do amazing science; please apply or forward to people that might be interested!

[Costanza Borrelli @cocoborrelli]

So happy to share this! You thought sequencing #granulocytes was tough? Try #eosinophils! These elusive little cells gave us a hard time, but there it is 👉https://t.co/XMbnirwcIo. 🧵 below

[Jan Michler @JanMichler]

3) By longitudinally tracking SARS-CoV-2 specific CD8+ T cell clones, we find that cytokine signaling marks cells destined to become memory, while mTOR signaling and a strong proliferative transcriptional signature correlate with clonal contraction and disappearance (Fig.4 e,f)

[Jan Michler @JanMichler]

Check out our new preprint from a great collaboration with @sarahadamo from the Boyman lab at @Unispital_USZ on bioRxiv: CD8+ T cell signature in acute SARS-CoV-2 infection identifies memory precursors. doi: https://t.co/4RG5b8zVz3

[Jan Michler @JanMichler]

2) This is the first description in humans of a trajectory of memory CD8+ T cells differentiating from Teffector/TEM to TEMRA with a concomitant upregulation of TCF1 after viral infection, revealing that CD8+ TEMRA constitute the main memory phenotype in periph. blood (Fig.3a-c)