Jarrett Renn Remsberg

Everything chemoproteomics and drug discovery @EliLillyandCo. Former American Cancer Society Fellow @scrippsresearch, ChemE @MIT, views and opinions are my own

[Chris Parker @_chrisgparker_]

Excited to share a new preprint! Using D2B“degrader-first” screening, we uncovered two unexpected routes to protein degradation involving DCAF11/16 and CRL3–SPOP. Our work adds to growing evidence that TPD can extend far beyond canonical mechanisms.
https://t.co/2sEbu6rH5t

[Matthias Mann Lab @labs_mann]

We are hiring! The Matthias Mann Lab @labs_mann @MPI_Biochem in Munich has 3 exciting postdoc openings in proteomics & computational biology. #MSProteomics #PostDoc
https://t.co/yvXie1JcQK

[Madeline E. Kavanagh @mads_chem]

Save the date for the 15th Activity Based Protein Profiling meeting #ABPP2027 happening in Leiden on 2-4th June 2027. Join the mailing list for program updates and registration: https://t.co/cIKpM1VKOx
#chembiol #proteomics #ABPs #Chemicalprobes @LED3hub @LeidenScience

[Jarrett Renn Remsberg @JarrettRenn]

@OdedRechavi There is no reason to confirm mass spec results with a western blot.

[Jarrett Renn Remsberg @JarrettRenn]

@armandcognetta Or how they are prioritizing the follow-up? You can't work on everything and getting both validation and cash via selling to pharma could be advantageous.

[Dan Nomura @DanNomura]

New from the Cravatt Lab!
Tryptoline stereoprobes reveal hidden cysteine ligandability — while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones.
Plus: GRPEL1 ligands disrupt its HSPA9 complex, rewiring mitochondrial biology.
A masterpiece of chemoproteomics + AI.

🔗 https://t.co/uwKZG2p9Fz

#ChemicalBiology #Chemoproteomics #Boltz2 #CovalentDrugs

[Jarrett Renn Remsberg @JarrettRenn]

Brilliant work! Very excited to see where this takes the field. Kudos to those who designed the screen, such an amazing and simple idea in hindsight (those are typically the best!).

[Prof. Nikolai Slavov @slavov_n]

I am very enthusiastic for improving fragmentation spectra & the research this empowers.

This means increasing the sensitive and scope of sequencing the immunopeptidome ==> better cell therapies.

https://t.co/2ettKM9nfS
1/2

[Katherine A Donovan @kdonovan1008]

Excited to be hosting next week’s DFCI TPD seminar! We’ll hear from two outstanding speakers, Rebecca Metivier and Martin Steger who will share their work on developing and applying mass spectrometry-based proteomics platforms to identify and catalog degrader targets.

[William Gibson @wgibson]

Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber!

If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out!

https://t.co/HeBrFiAzM8

[Jarrett Renn Remsberg @JarrettRenn]

@michaellazear @HashtagGriswold Next big paper - cysteine ABPP of different farm animals.

[Jarrett Renn Remsberg @JarrettRenn]

Great visualization and reminder of timescales for biological processes. I remember first seeing something like this in @UriAlonWeizmann's System Biology textbook (which was formative in my decision to move into biophysics for grad school).

[Prof. Nikolai Slavov @slavov_n]

Timescales in Cell Biology

[Jarrett Renn Remsberg @JarrettRenn]

@nesvilab @michaellazear I’m genuinely sad you felt bullied by these discussions. I found this insightful (albeit surprising) to hear everyone’s perspectives. Special thanks to @mjmaccoss and others for steering some of the conversation.

[Jarrett Renn Remsberg @JarrettRenn]

@neely615 Reminds me of the discussions of "statistically significant" vs "biologically meaningful"

[Jarrett Renn Remsberg @JarrettRenn]

@chrashwood @nesvilab @michaellazear @fcyucn @animesh1977 @GeorgWa @ucdmrt @maxquant @github @JimmyEng It resonates because at its core, NIH funded work should be accessible to the entire research community. This ranges from software being open-source to publications not being behind a pay wall. Majority =/= all (unfortunately)

[Jarrett Renn Remsberg @JarrettRenn]

Stacked lineup of heavy weights in the field, looks to be a great conference!

[Stephan Hacker (inactive account) @StephanHacker2]

Registrations are now open for the 14th ABPP conference @abpp2025london on March 30th to April 2nd, 2025, at the Francis Crick Institute. An amazing lineup of speakers. Very much looking forward to catching up with everyone. https://t.co/m4pbbNIqBR

[Jarrett Renn Remsberg @JarrettRenn]

Super cool work from the @Michael_A_Erb lab! I had the pleasure to hear it recently and excited to see it out now. Molecular glues and SuFEx chemistry make for a great story!

[Michael Erb @Michael_A_Erb]

We keep stumbling on molecular glues, but how can they be made for a pre-selected target? We’ve been working on this question, envisioning a high-throughput chemistry (HTC)-based approach to convert pre-existing ligands into molecular glues. https://t.co/7ppA24BQVK

[Jarrett Renn Remsberg @JarrettRenn]

@chrashwood Yes! Can finally get my hands on an Astral

[Jarrett Renn Remsberg @JarrettRenn]

@ProteomicsNews nice hardware flex :|

[Jarrett Renn Remsberg @JarrettRenn]

Great review for anyone interested in chemoproteomics and drug discovery! Proud to have been part of many of these stories and discoveries during my time in the Cravatt lab and excited for what's to come!

[Jarrett Renn Remsberg @JarrettRenn]

@SafeChem79 @KRHornberger I had registered Holsteins, Brown Swiss, and did dairy judging. Can I jump on this bandwagon?