Jason Zhenyi Hu

PI @Shanghai Institute of Organic Chemistry, CAS; Postdoc w/ Crews lab @Yale; PhD @Colorado Boulder. Chemical Biology; PROTAC; PhosTAC

[Jason Zhenyi Hu @JasonHu222]

Celebrating the first anniversary of Hu ChemBio lab, and enjoy the early summer days of Shanghai!

[Jason Zhenyi Hu @JasonHu222]

Super excited to see our PhosTAC work being featured by Craig and Prof. Bertozzi😀

[Jason Zhenyi Hu @JasonHu222]

In this study, we combined the “occupancy-driven modality” of TKIs with the “event-driven modality” of bifunctional molecules to achieve dual inhibition of EGFR with TKI-based PhosTAC, which reveals differential downstream effects.

[Jason Zhenyi Hu @JasonHu222]

I’m thrilled to share our recent work on dual inhition of EGFR with PhosTAC. Congrats to the team @POHANCHEN9, Wenxue, @siszheng, @JacquesSaarbach, Ines and John. And we are deeply grateful for the great mentorship from @Yanshen73854711 and @CraigMCrews!

https://t.co/zJIl04JJZm

[J. Am. Chem. Soc. @J_A_C_S]

Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality @CraigMCrews @ToddDouglasPhD @Yanshen73854711 @Yale @YaleChem @YaleMed #Dephosphorylation #Tau #Chimeras #PhosTACs #Therapies @sciam @NYT
https://t.co/t8JxV7Q81T

[Jason Zhenyi Hu @JasonHu222]

@AdrianBebenek @CraigMCrews @J_A_C_S Thanks Adrian!

[Jason Zhenyi Hu @JasonHu222]

@ToddDouglasPhD Thanks for the shout out, Todd

[Jason Zhenyi Hu @JasonHu222]

@POHANCHEN9 @CraigMCrews Thanks for the great work!

[Jason Zhenyi Hu @JasonHu222]

Excited to share our Tau PhosTAC paper on @J_A_C_S . PhosTAC provides a new modality for neurodegenerative diseases treatment. Many thanks to @CraigMCrews, and the awesome team Po-Han Chen, Wenxue Li, @ToddDouglasPhD , John @Yanshen73854711 🎉#PhosTAC
https://t.co/JIRlDIm8Fp

[Craig Crews @CraigMCrews]

Ever wanted to dephosphorylate just a single phosphoprotein instead of blocking all downstream kinase substrates with a kinase inhibitor? Check our new PoC paper describing PhosTACs that recruit phosphatases to selected phosphoproteins. #PhosTACs https://t.co/hjZ37e6b6R