Jacques Saarbach

Scientist (chem-bio) and Trail Runner

[Armand @armandcognetta]

Announcing General Proximity's $12M, 2x over-subscribed, pre-Series A round.

Medicine is in the dark ages. Our understanding of biology far exceeds our ability to perturb it therapeutically.

[Jacques Saarbach @JacquesSaarbach]

After years seeing the field focus on TPD or specific PTMs, we're expending induced proximity medicines to a wider scope.

[Armand @armandcognetta]

How?

~10% of your genome codes for proteins that modify other proteins.

At GP we call this the 'effectome'. The effectome is made up of all post-translational modification (PTM) proteins (readers/writers/erasers), as well as chaperone, adaptor, and trafficking proteins.

[Jacques Saarbach @JacquesSaarbach]

A good question, and I believe we have some answers.

[Armand @armandcognetta]

A little about our technology.

GP was founded on a simple, first principles premise:

Proximity is inarguably a key regulator of biology and all major disease processes.

Yet only a minuscule fraction of existing drugs work through proximity.

[Jacques Saarbach @JacquesSaarbach]

Beyond excited to be part of this adventure!

[Armand @armandcognetta]

General Proximity (@proxbio) is coming out of stealth.

General Proximity is developing a new class of medicines that we believe has the potential to decrease global disease burden, transform human health, and extend lifespan more than any other current therapeutic modality. 🧵

[Jacques Saarbach @JacquesSaarbach]

@AngeraniSimona Congrats Simona. Happy to see the paper finally out!!

[Michael Lin, MD PhD 🧬 @michaelzlin]

Fellow academics, when are we going to start fixing our urgent structural problems that strain family bonds and present ongoing barriers to diversifying our educational and scientific leadership? You wonder, what the heck is this guy talking about?
1/n

[Jacques Saarbach @JacquesSaarbach]

@WinssingerLab Well done Remi! Congrats.

[Coco Laurin @CorentineLaurin]

Are you a postdoc in life sciences? Are you nearly ready to transition to Faculty positions? Check out this amazing symposium focused on helping #futurePI from all backgrounds! #womeninSTEM #WomenInScience #LGBTQinSTEM #DisabledinSTEM #blackinstem #LatinxInSTEM

[Jacques Saarbach @JacquesSaarbach]

Can't believe I'm only seeing this now. It's brilliant 😂. Happy Halloween!

[Craig Crews @CraigMCrews]

I'm deeply honored to receive the 2020 Heinrich Wieland Prize and want to thank the many lab members who have helped launch the #targetedproteindegradation field over the past 20 years. #PROTACS #Yale https://t.co/Ki8ni9mKNY

[Craig Crews @CraigMCrews]

I heard a joke about #PROTACs but it’s degrading to discuss it.