New @biorxiv_micrbio preprint from our group: "Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone in Pseudomonas spp.” Great work from @TheRealAlimoff with some important biochemical data from @TeufelLab
Move over titin... introducing PKZILLA as the largest protein in life that makes one the largest nonpolymeric compounds in biology, the marine polyether toxin prymnesin. Congrats to @photocyte & @VikShende and rest of team! https://t.co/MxPldVS9xx
Applications are OPEN for the tenth John Innes–Rudjer Bošković Summer School on Applied #Molecular#Microbiology
🗓️ Deadline - 2 February 2024
Find out more & apply: https://t.co/NA31T4l9HR
@IUCDubrovnik@NorwichResearch
In a new paper in @Nature, an impressive and creative series of insights led @DDunkelmann and coworkers in Jason Chin’s lab to develop a powerful, general in vitro selection for aminoacyl-tRNA synthetase enzymes that charge tRNAs with a wide variety of small molecules, including those not necessarily compatible with known ribosome variants (yet). They used this system to create aaRSs that enable beta-amino acids and alpha,alpha-disubstituted amino acids to be site-specifically incorporated into proteins, solved the structure of GFP containing meta-brominated beta-phenylalanine as the third residue as confirmation, and advanced the non-canonical biopolymer field forward in the process.
Wow. Brilliantly explained in the thread below. 👏👏🍻
Today seems like a good day to announce some improvements we've had in the works:
1. We promised lower prices as our sequencing volume increased, and thanks to our wonderful customers, as of right now we are dropping our price from $25 to $15/sample! (1/6)