Journal of Cell Biology

The Journal of Cell Biology (JCB) publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress

[Journal of Cell Biology @JCellBiol]

New study led by Lei Wang from the Institute of Biophysics of @CAS__Science (https://t.co/qeo662CiWJ) has revealed two coordinated molecular mechanisms that maintain efficient protein phosphorylation in the Golgi apparatus during lactation. 👉 https://t.co/QW8Ba9Ea82

[Journal of Cell Biology @JCellBiol]

Spotlight: Muniesa-Vargas, Lans et al. (https://t.co/Wne6jjsvFm) provide insight into the mechanisms that regulate the dynamics of XPG recruitment & release during nucleotide excision repair. Opresko and Schärer highlight the findings: https://t.co/sdlLo8PbUU

[Journal of Cell Biology @JCellBiol]

Yang et al. show that the secretory pathway kinase Fam20C is retained in the #Golgi via Fam20A-mediated membrane anchoring. Mislocalizing Fam20C alters #secretome phosphorylation, leading to reduced milk quality and subsequent growth retardation in pups. https://t.co/3gvfYk9jUk

[Journal of Cell Biology @JCellBiol]

Yan G. Zhao et al. @SUSTechSZ reveal that during nutrient scarcity, the lipid droplet–localized PISD isoform, PISD-LD, ensures survival by bridging #LipidDroplets to #mitochondria for β-oxidation while simultaneously inhibiting #lipophagy: https://t.co/ImPXf4j7TK

[Journal of Cell Biology @JCellBiol]

Ndoci et al. (https://t.co/VwFP8yYcF9) reveal a system by which mitochondria prioritize CoQ retention when the mevalonate pathway is impaired, preserving respiration at the expense of antioxidant defenses. Spotlight by Sato, Friedmann Angeli et al.: https://t.co/DX1xJmNV0Z

[Journal of Cell Biology @JCellBiol]

Weikang Fan et al. reveal how nutrient sensing in #Drosophila intestinal epithelial cells controls stem cell activity. Inhibition of Rag GTPases or mTORC1 in enterocytes non-cell autonomously promotes ISC proliferation via Upd3–JAK–STAT signaling. https://t.co/lNPfDxgcyV

[Tsukasa Makino @TsukasaMakino2]

Our movie explaining tension-induced regulation of kinesin-1 stepping.

[Journal of Cell Biology @JCellBiol]

See a recent JCB study from Youfang Zhou and Xianfeng Wang et al. of the Wu-Min Deng lab, "Polyploidy reprograms epithelial cells for motility and phagocytosis via stress signaling"
👉 https://t.co/natmi0r9vg

📰 Press release: https://t.co/xQPoJse7Yl

[Journal of Cell Biology @JCellBiol]

“We greatly appreciated JCB’s support in highlighting the significance of our study. The outreach efforts helped communicate our findings to a broader scientific audience.” — Wu-Min Deng
Why publish in JCB? 👉 https://t.co/JNzNMhsTKG

[Journal of Cell Biology @JCellBiol]

Emily Glover, Kevin Wilkinson, Ian Collinson et al. @BristolUni show that cells subject to mitochondrial protein import failure induce Intercellular Mitochondrial Transfer via tunnelling nanotubes. https://t.co/YZ3xCddMSE

#Organelles #Biochemistry #Mitochondria

[Journal of Cell Biology @JCellBiol]

Yasushi Izumi and Mikio Furuse @SEIRIKEN1977 show that the exclusion of apical aPKC by septate junction proteins in #Drosophila enteroblasts is required for stem cell homeostasis via the Kibra–Yorkie pathway. https://t.co/1QPtpTg9gG

#Adhesion #StemCells #Development #Polarity

[Journal of Cell Biology @JCellBiol]

Mia S. Frier, Elizabeth Conibear et al. show that the VPS9 GEF complex VINE unexpectedly recruits a phosphatase that stimulates GAP-mediated Rab5 inactivation, revealing dual control of Rab signaling by a single complex. https://t.co/sVehc7wm4s

#GTPases #Organelles #Trafficking

[Journal of Cell Biology @JCellBiol]

Our July issue is here! https://t.co/lVVkPOw7r6 The cover shows an immunofluorescence image of a TNFα-inflamed mouse cremaster muscle acquired w/ a Nikon A1 confocal microscope. Green, cortactin; magenta, CD31 (vessels); cyan, MRP-14 (neutrophils).
See https://t.co/jaPAD7gCuO

[Journal of Cell Biology @JCellBiol]

The discovery of a novel trafficking domain in unorthodox AQP12 by Chauvigné, Cerdà et al. yields insight into the channel’s native membrane function and its molecular regulation in intracellular yolk platelets and pancreatic zymogen granules. https://t.co/qYiSKT8R6F

[Journal of Cell Biology @JCellBiol]

Rajan, Yoon, Terman, Reisler et al. identify mechanisms for assembling & disassembling complex networks of multi-protein–bundled F-actin, including a synergism between different bundlers and disassemblers in these processes. https://t.co/249eW2MCjY

#Cytoskeleton #Actin

[Journal of Cell Biology @JCellBiol]

Alba Muniesa-Vargas, Hannes Lans et al. (Erasmus MC) use live-cell imaging to uncover how XPG activity is dynamically controlled during nucleotide excision repair. https://t.co/2YYWZStFu2

#DNAbiology #Genetics #DNArepair

[Journal of Cell Biology @JCellBiol]

Keegan, Dunleavy et al. show that, in #Drosophila, a new pool of constitutive #centromere protein CENP-C is loaded at the centromere in prophase of #meiosis I. This pool is critical for #kinetochore assembly and meiotic chromosome segregation. https://t.co/5a28x9VAW6

[Jeremy Baskin @basktastic]

Thrilled to share this #lipidtime story in @JCellBiol where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!

[Journal of Cell Biology @JCellBiol]

How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. https://t.co/mTsss8ZZcX

@basktastic @weillinstitute @CornellChem

[Journal of Cell Biology @JCellBiol]

Jenkins, Botelho et al. show that the PIKfyve #lipid kinase extends its sphere of influence to modulate the architecture & dynamics of the ER by balancing phosphoinositide species at their inter-organellar sites. https://t.co/WeRlcklpMf

#Organelles #Membrane #ER_literature