Jenni Chlebek, PhD

Postdoc at Lawrence Livermore National Lab. Graduate from the Dalia Lab at Indiana University. Microbiologist / synthetic biologist 🦠🔬

[Jenni Chlebek, PhD @JenniChlebek]

How do some bacteria retract their pili without a retraction motor? In our latest paper @PNASNews (and my favorite from the Dalia Lab), we show that many pili are likely inherently unstable and spontaneously depolymerize. https://t.co/BuCxutaK1C

[Jenni Chlebek, PhD @JenniChlebek]

Would you like to improve the stability of your genetic circuit? Maybe our method could help! Here we use synthetic entanglement to control the evolution of a toxic gene and enhance its stability. See the collaborative effort from LLNL published now in NAR
https://t.co/sTrWxoAt8s

[Jenni Chlebek, PhD @JenniChlebek]

My first postdoc paper is on bioRxiv! We demonstrate that sequence entanglement--in which two genes are encoded within different reading frames of the same DNA sequence--improves the evolutionary stability of high-cost genetic components. Read more here: https://t.co/8ewcwYw0gX

[Maria Sandkvist @SandkvistMaria]

Export signal recognized by a type IV pilus: Mechanism of secretion of TcpF by the Vibrio cholerae toxin-coregulated pilus | Proceedings of the National Academy of Sciences https://t.co/ofx04VtsWT

[B is @[email protected] @[email protected] @thuronyi]

Minipreps! They're a fact of life. But if they don't bring you joy, you might want to try new tactics or treat yourself to some fun new toys!

Our lab has done 2,625 minipreps so far. Let me share a few tidbits about our approach and our favorite pieces of equipment. 🧵 (1/n)

[Courtney Ellison @C__Ellison]

My lab is hiring! We are looking for a full time lab tech for 1-2 years who is interested in getting more scientific research experience. Please reach out if you have any questions, and please forward to anyone you think may be interested! https://t.co/YXlN5FWKCn

[Jenni Chlebek, PhD @JenniChlebek]

Thank you to all of our co-authors for providing very helpful ideas, analysis and feedback! @spleonard1

[Jenni Chlebek, PhD @JenniChlebek]

My first postdoc paper is on bioRxiv! We demonstrate that sequence entanglement--in which two genes are encoded within different reading frames of the same DNA sequence--improves the evolutionary stability of high-cost genetic components. Read more here: https://t.co/8ewcwYw0gX

[c0nc0rdance @c0nc0rdance]

In 2018, "Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial" was published in the British Medical Journal.

It sought to determine if wearing a parachute when jumping from a plane had any impact on survivability.

It did not.

[David Grainger @GraingerLab]

Latest paper from the lab, this one's the culmination of @lucas_walker92's PhD. He describes how two TFs can bind the same DNA site to regulate in V. cholerae.

A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae https://t.co/qkORz6oTCz

[Hannah Hughes @katyq42]

My 2nd paper is out! We found that PilT primes the extension complex in MSHA pili. Yes- this retraction motor is required for extension!
We started out intrigued by an unusual control strain and ended up revealing interesting facets of pilus regulation.
https://t.co/q4DwrlMLPb

[Tim Sainburg @tim_sainburg]

Now published in Research Policy:

I looked at 27k postdoc salaries across the US, their relationship to cost of living, tenure-track job prospects, and how things have been changing over time. Here's what I found:
https://t.co/cLXPAcTjYI

[Sean Leonard @spleonard1]

Great research and a fair postdoc wage CHECK THESE OUT. I’m ~1 yr into a post doc at LLNL and love it!

[Julia van Kessel @Biolluminator]

Our team won the IU Idea to Startup pitch competition! 💪Very proud of how far we have come. Internal funding➡️ screens➡️lead compounds➡️in vivo assays. Led by two (previously) NTT women faculty 👩‍🔬👩‍🔬 and experiments by students!

Stay tuned…company startup to be announced soon!

[Dr. Jennifer Pett-Ridge @Jeffinerca]

So many misconceptions re nat’l lab jobs:
- less intellectual freedom (no, just have to find support $$)
-‘hard $$’ salaries (no, have to raise $$ from grants)
-more bureaucracy (nope, just different)
-our positions are ‘lesser-than’, less prestigious than faculty jobs..grrrr 🙄

[Jenni Chlebek, PhD @JenniChlebek]

@Biolluminator @IUB @IUBiology Wow what a big group! That patio brings back such good memories. Wish I could have made it out this year ❤️ Hope you're all having a great time!

[Julia van Kessel @Biolluminator]

Look at ALL the IU people at Phages! Current, past, all phamily! #Phages2022 @IUB @iubiology

[bioRxiv Synthetic Biology @bioRxiv_synbio]

Comprehensive analysis of kill switch toxins in plant-beneficial Pseudomonas fluorescens reveals drivers of lethality, stability, and escape

https://t.co/upJDq2rvWu
#biorxiv_synbio

[Sean Leonard @spleonard1]

Apply to these post-doc openings with Howard Ochman and Nancy Moran! https://t.co/ity99QsjuU
I _really_ enjoyed my training with Nancy, and the labs are exciting places to work full of people with diverse interests and skills. Just incredible science done there. Please retweet!

[Hannah Hughes @katyq42]

Why do MSHA pili not exhibit hyperpiliation upon deletion of the retraction motor? Because in this system, the retraction motor is actually involved in extension!
Check out my new preprint to learn more:
https://t.co/0xd3y7Rn7r

[Sean Leonard @spleonard1]

Apropos of nothing, Postdocs at LLNL start off >100K annual salary and we do research, write, etc. So if you’re looking for a liveable PD, check us out! We have openings in Synbio and more on the way!