Jesse Dabney

Formerly lab-based genomics of dead things.
Currently computation-based omics of living things.

[Jesse Dabney @JesseDabney]

What cool news! Congrats to Svante, and to the teams throughout the years, who took us from molecules to genomes, and opened a window into the past. Amazing!

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

[Korro Bio @KorroBio]

Jesse Dabney, a leader on our bioinformatics team – and quite possibly the best scuba diver in the company ­­– is our #KorroKrew spotlight for February!

[Jesse Dabney @JesseDabney]

We're hiring! Sr. Scientist in NGS, with emphasis on RNA related molecular techniques to explore RNA editing. https://t.co/ga2UKYsdA6

[Jesse Dabney @JesseDabney]

@neuralengine This is just as myopic and unnecessary as people who have said things like there's nothing left to discover in physics. You may not take anything from philosophy now, but I doubt you could disentangle the coevolution of the fields.

[Jesse Dabney @JesseDabney]

We're hiring at @KorroBio!
3 positions in the data science/bioinf group. We're looking broadly for bioinf/compbio, cheminf, and general data science experience to work in oligo design, RNA editing and target biology. Check out the jobs here: https://t.co/LUYSzJtjRf

[Jesse Dabney @JesseDabney]

3. based on in vitro decay rates, it was estimated that DNA could survive on the order of 1e4 years.

Well done to all involved in setting the new record!

[Jesse Dabney @JesseDabney]

Passing the 1e6 year old DNA barrier marks a good time to revisit the foundational Lindahl 1993 paper "Instability and decay of the primary structure of DNA" :
https://t.co/4NIk05csdY

[Jesse Dabney @JesseDabney]

1. It has an awesome title.

2. A case can be made that every subsequent aDNA damage paper is a recapitulation of this paper. And..

[Jesse Dabney @JesseDabney]

@AnthonyC1Nash I've used BiomaRt and a package called annotables in the past for mapping between IDs. Not sure if the latter is still maintained.

[Jesse Dabney @JesseDabney]

@AnthonyC1Nash For bulk, this will get you up and running quickly: https://t.co/Pa1bvZpS2z. Or if you're looking for single cell, this is a great one: https://t.co/RwdqfqgB8m

[Jesse Dabney @JesseDabney]

One cool thing about moving to industry is that my family thinks I've finally finished school.

[Jesse Dabney @JesseDabney]

A bit delayed, but I've recently started a new compbio position with @KorroBio, working to develop ADAR-based RNA editing therapies. Looking forward to the new scientific focus, and the non-academic setting!

[Jesse Dabney @JesseDabney]

@jafellowsyates Glad to see the protocol still contributing!

[Jesse Dabney @JesseDabney]

@austenapigo @tylergbyers I disagree with your original post on all 3 points, and think you might be missing the irony in this one accusing others of being savior-y.

[Jesse Dabney @JesseDabney]

@riveramichael @haspelmath @MPI_SHH I'm sure that was sarcasm, but to give some deeper insight, Haspelmath used to question whether there was any scientific proof of evolution, and demanded that books on intelligent design be kept in the library.

[Jesse Dabney @JesseDabney]

@AnthonyC1Nash I've had varying experiences with this in academia. Was part of a team with a clear lab goal where many projects were connected to each other. And also have had very independent projects. Just started a new position in industry, and very interested in comparing the dynamics!

[Jesse Dabney @JesseDabney]

Developments from aDNA are being used for coronavirus testing, very cool.

[Pontus Skoglund @pontus_skoglund]

For the ancient DNA crowd: the modded extraction is based on the Dabney buffer https://t.co/ucgMWQy8Md with silica beads as in Rohland, Glocke https://t.co/VgDiJpNzo6. Maria Greco @TheCrick tested it for RNA with
@CharlesSwanton based on her work with Isabelle Glocke in our lab.

[Jesse Dabney @JesseDabney]

An artistic perspective on machine learning. My friend Alex Estorick explores how artists use ML algorithms and the discourse around the (de)generative process. https://t.co/e4d8A75X3M

[Jesse Dabney @JesseDabney]

@MichaDannemann @unitartu Congrats! Hope there's room for a kicker table.

[Jesse Dabney @JesseDabney]

With some modifications, the Dabney Protocol works with poo too: https://t.co/Oxzde53vTO