Our GzESTY paper is online. We optimized a cell based assay to sensitively detect GPCR activation in response to ligand application or in complex mixtures containing endogenous ligands. GzESTY was designed to aid in GPCR deorphanization efforts.
https://t.co/zJ5P5Fo0vS
🔬 The 2nd round of GPCRmd data is out! Covering 60% of GPCR structures, it reveals allosteric sites & lateral gateways into the receptor core.
🔗 Read: https://t.co/3nS4RYFZJy
#GPCR#GPCRmd#MolecularDynamics
Explore it with our new tools: https://t.co/JE7zdVdM7d
Excited to share our new preprint on the #Hedgehog pathway! We uncover how #Smoothened (SMO), a noncanonical #GPCR, binds & inhibits #PKA via an intrinsically disordered region, mimicking known GPCR/PKA signaling complexes despite minimal sequence similarity. #AlphaFold#IDR
We are thrilled beyond words to see our LYCHOS (GPR155) publication out today in @Nature. 🥳
“LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR”
https://t.co/I7ibRphMzS
🧵
📔SAVE THE DATE! 🗓️
The 2nd WntUK national meeting will be held at @WorcCollegeOx@UniofOxford on Monday 24th March 2025.
Registration and abstract submission opens November 2024.
Wnt researchers of all levels and disciplines welcome from the UK and beyond!
Tomorrow is THE DAY! 🎉
We're kicking off the #4th_Transatlantic_ECI_GPCR_Symposium. This is the final reminder for registration!
Besides the amazing keynote speakers, and career and lunch/dinner panelists, we have wonderful #ECI speakers who will present their latest research!
Big congrats to our #CCeMMP members for their 2025 @arc_gov_au#DECRA awards! 💫🏆🎊
@SarahJ_Piper Understanding structure, dynamics and function of receptor splice variants
@brianpcary - Leveraging electron microscopy to study receptor structure and function.
@MIPS_Australia
Big congrats to our #CCeMMP members for their 2025 @arc_gov_au#DECRA awards! 💫🏆🎊
@SarahJ_Piper Understanding structure, dynamics and function of receptor splice variants
@brianpcary - Leveraging electron microscopy to study receptor structure and function.
@MIPS_Australia
Our @arc_gov_au CCeMMP 'Bench to Art' Exhibition is now open to the public for @Aus_ScienceWeek 🤩 with 28 amazing entries from around the world! Check out the link below and vote for your favourite artwork in the People's Choice Award. 🏆https://t.co/MBpKcSV21w
#Scienceweek
Now published in @PLOSBiology: How GRK kinases control #GPCR signaling in the #Hedgehog transduction cascade in primary #cilia.
https://t.co/BRi7tOMZ4A
Working on #cryoEM for membrane proteins?
This new #CryoSPARC case study covers end to end advanced processing of a 73 kDa inactive state GPCR, including challenges and pitfalls, detailed figures and final maps. Read in full here: https://t.co/5Xtl0zYID2
Congratulations to the recipient of Peter Doherty Investigator Grant Award in Leadership, @PatrickMSexton1 of @MIPS_Australia, @CCeMMP and @MIPS_DDB for his research on improving our understanding of G protein-coupled receptors. Read more on our website: https://t.co/e3uR3nlBCs
Don't miss out! The 10th International Conference on Electron Tomography is from January 28-30, 2025, in Melbourne.Registration is open now!
https://t.co/tTnfLmVAAg
#CryoEM#Tomography#TEM