Alejandra Tomás Catalá

Professor & Head of Section of Cell Biology and Functional Genomics @imperialcollege. Spatiotemporal regulation of signalling of metabolically relevant GPCRs.

[Alejandra Tomás Catalá @TomasLab_ICL]

Amazing 2 days discussing the latest research at the @Soc_Endo Endocrine Metabolic GPCRs 2026 Meeting. Fantastic speakers from different angles: cell biology, physiology, drug discovery, etc. Icing on the cake was our very own PhD student Linda Wong winning the Best Poster Award!

[Eric Topol @EricTopol]

Independent of weight loss, semaglutide (Ozempic) improves knee arthritis by cartilage restoration, in both the mouse model and a small randomized clinical trial
@Cell_Metabolism https://t.co/yy1D1xiMm4

[Alejandra Tomás Catalá @TomasLab_ICL]

Great opportunity to join us at Imperial - 20 Assistant Professor positions at the Faculty of Medicine have just been advertised. See below:

https://t.co/ykUlewrDri

[Alejandra Tomás Catalá @TomasLab_ICL]

@DUK_research Thanks to all the coauthors, particularly Denise Wootten and Giuseppe Deganutti for the cryo-EM and MD simulations, and the first author, former PhD student Liliane El Eid

[Alejandra Tomás Catalá @TomasLab_ICL]

I am delighted to report that our latest paper has now been published in Science Advances:
https://t.co/4zxfrizMSo
In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology.

[Alejandra Tomás Catalá @TomasLab_ICL]

Here is a link to an article about our study on the website of our funder @DUK_research: https://t.co/koHAsAl8FV

[Fusion Conferences @Fusion_Conf]

📢We are excited to announce the initial speaker line-up for our #MembraneContactSites conference

⭐️Join us in Mexico in November 2026 to hear directly from the leading researchers in the field

➡️See who’s speaking and reserve your spot here! https://t.co/ccBEvYNiZK

[Journal of Clinical Investigation @jclinicalinvest]

Signaling Architecture of the Glucagon-Like Peptide-1 Receptor

In this contribution to JCI’s Review Series on Clinical Innovation and Scientific Progress in #GLP-1 Medicine, Gregory O Austin & Alejandra Tomas @TomasLab_ICL @imperialcollege explore the spatiotemporal regulation of #GLP-1R signaling: https://t.co/O40Lok2vpF

[Di Jiang @dijiang319]

🔬@ScienceMagazine A genetically encoded device for #transcriptome storage in mammalian cells | Science https://t.co/AwHQtnKzsV @kevin921tw @insitubiology

[Fei Chen Lab @insitubiology]

Thrilled to share our newest method for transcriptome recording using TimeVault!
https://t.co/pqdSzjhn5J

[Cell @CellCellPress]

Now online! Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo https://t.co/uEFUr9XGO7

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Heterogeneity, dynamics and organelle interactions of lipid droplets https://t.co/vGUvKcXuRW

[Alejandra Tomás Catalá @TomasLab_ICL]

Thanks for including our work in this amazing JCI Series on GLP-1 https://t.co/7eh3aLNFQv

[Daniel J Drucker @DanielJDrucker]

Can one optimize next generation GLP-1 medicines through deconstructing of GPCR signaling? @jclinicalinvest https://t.co/33DwiLtBgc

[Alejandra Tomás Catalá @TomasLab_ICL]

Extremely happy to be part of this amazing series https://t.co/7eh3aLNFQv

[Alejandra Tomás Catalá @TomasLab_ICL]

Our review is now out in JCI, where we discuss current evidence for the existence of GLP-1R–cAMP–PKA signalosomes at different subcellular locations, and the complexity of the GLP-1R spatiotemporal signaling architecture:
https://t.co/LI8rnc8tXY