Jon Brown Lab

Twitter for the Jon Brown Lab, located in the division of cardiovascular medicine at Vanderbilt University Medical Center. @VUMChealth 🧬 ⚓️

[Kimryn Rathmell @KimrynRathmell]

Happy Thanksgiving 🦃🍁🍽 from this rockstar ⁦@VUMCMedicineRes⁩ ⁦@VUMC_Medicine⁩ team! Grateful to get to work alongside these amazing doctors. #WomenInMedicine Thx to all #healthcareworkers serving today!

[Jon Brown Lab @JonBrownLab]

@chasz43 @JonathanBrownMD @VandyBiochem 🎉

[Jon Brown Lab @JonBrownLab]

@JonathanBrownMD @VandyBiochem So proud of Ronan! Excellent work 🎉

[Jonathan Brown @JonathanBrownMD]

Congrats to Ronan Bracken graduate student in @JonBrownLab. Advancing to PhD candidacy in @VandyBiochem. #donewithquals!!! 🙌🧬🧬🧬

[Circulation Research @CircRes]

Join us in welcoming our new #TechnicalEditor @CircRes Dr. Amanda Doran MD PhD from the Division of Cardiology @VUMC_heart. Her research focuses on the role of innate immunity and #inflammation resolution in #atherosclerosis. Congratulations! @AmandaDoranLab

[Javid Moslehi @CardioOncology]

Big congrats to outstanding colleague & "Cardio-Immunologist" extraordinaire! & fellow PRB3 "neighbor" (well...until a few months ago)! @VUMChealth @VUMC_heart @AmandaDoranLab @JonathanBrownMD @JonBrownLab @JaneFreedmanMD @CircRes @AHA_Research @annetkiraboc1 @nhpetunia

[Luke Koblan @LukeKoblan]

Our recent publication was reviewed in NEJM today! @davidrliu, @NIHDirector, @JonBrownLabVUMC, @Progeria, @mrrerdos The figure is absolutely killer!

Will definitely be sending this to my mom.

https://t.co/eRAr8RaR14

[Javid Moslehi @CardioOncology]

Excited to have Dr. Mac Linton present at @VUMChealth CV Research Series. Terrific colleague, scientist & even better hogfish cook & host! @JaneFreedmanMD @KathrynMooreLab @merrymanlab @alan_daugherty @JoshuaBeckmanMD @VAgrawalMDPhD

[Jonathan Brown @JonathanBrownMD]

Read this study from Paul Cohen @RockefellerUniv about Brown Fat in humans and risk of cardiometabolic disease. Nice to see independent work from former @BrighamFellows. https://t.co/ATScpg7Zqx

[Nature Portfolio @NaturePortfolio]

The findings of a study in Nature demonstrate the potential of in vivo base editing as a possible treatment for Hutchinson–Gilford progeria syndrome and other genetic diseases by directly correcting their root cause. https://t.co/9FMUuY3TzA

[Nature Portfolio @NaturePortfolio]

News & Views: No cure exists for the lethal premature-ageing condition Hutchinson–Gilford progeria. A gene-editing tool offers a way to treat the condition in mice, according to a Nature paper. Could this approach lead to an effective therapy? https://t.co/SKZhd7teEE

[Nature Reviews Drug Discovery @NatRevDrugDisc]

In vivo base editing shows promise in treating the genetic accelerated-aging disorder Hutchinson–Gilford progeria syndrome in mice - find out more in our latest highlight of research by @jonbrownlabVUMC
@davidrliu @LiuGroup et al. https://t.co/hvQBfHResT

[Vanderbilt School of Medicine Basic Sciences @VUBasicSciences]

Research from the @JonBrownLabVUMC and collaborators have rescued mice afflicted with progeria—accelerated aging—which could lead to a cure for Hutchinson-Gilford progeria syndrome in humans.

https://t.co/tkA2lh3tSw

[Javid Moslehi @CardioOncology]

Congratulations to @SarnoffCardio & @BrighamFellows alumnus/current @VUMChealth cardiologist Dr. John Brown. Really nice story & demonstrating power of teamwork. Can studying progeria provide insights into CV aging? @JonBrownLabVUMC @saptarsi_haldar @tmmichelangelo @Progeria

[Eric Topol @EricTopol]

Great science marches on.
A rare incurable disease—progeria—tackled by #CRISPR genome editing with striking results in mouse model
https://t.co/y4RWpB3yRX
@nature @davidrliu @NIHDirector @LukeKoblan @JonBrownLabVUMC
David's ★🧵👇
https://t.co/9tLFsHoQze

[Jonathan Brown @JonathanBrownMD]

Full text here: https://t.co/CdnGxSpxMp

[Jonathan Brown @JonathanBrownMD]

So proud of this work demonstrating DNA base editing treatment for #progeria in human cells & mouse model. Amazing collaborative team @davidrliu @NIHDirector @LukeKoblan & Mike Erdos at NIH and my @VUMCResearch team @lindsaymdavison & Sean Doherty
https://t.co/6MN8Nq4gxt

[Luke Koblan @LukeKoblan]

Here is a really great article about our progeria work that mentions the early days where we only had DNA editing data from only a single LMNA c.1824 C>T mouse– @davidrliu, @JonBrownLabVUMC, and @NIHDirector may remember fondly! Check it out here: https://t.co/W1cEH6YyWJ

[David R. Liu @davidrliu]

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 https://t.co/O7dkEYpndg