Jon Emery

Infectious disease modeller with interest in tuberculosis natural history @LSHTM, @cmmid_LSHTM and @LSHTM_TB

[Jon Emery @JonCEmery]

Our paper estimating the infectiousness of subclinical tuberculosis and its contribution to transmission has now been published in elife.

https://t.co/xJPtnebzmQ

[Jon Emery @JonCEmery]

Our preprint estimating the infectiousness of subclinical tuberculosis and its contribution to transmission is now out on medRxiv.

https://t.co/do8AlfBsTh

NOT YET PEER REVIEWED

[Jon Emery @JonCEmery]

@dopapus @tomayates @petermacp @LeoMarti_EpiTB @petedodd24 @Rein_Houben I'd also bear in mind that the sample sizes available led to fairly wide uncertainty intervals. I think the important conclusion is that our lower bound suggests that the infectiousness of subclinical TB is unlikely to be negligible.

[Jon Emery @JonCEmery]

@dopapus @tomayates @petermacp @LeoMarti_EpiTB @petedodd24 @Rein_Houben Thanks all for reading and glad it's interesting!

@dopapus we used crude ORs in the preprint but haven't seen any material variation when adjusting for age and sex. This is something we could look to include as a sensitivity though.

[Jon Emery @JonCEmery]

@tomayates @petedodd24 @Rein_Houben @petermacp Do let me know if you have any further thoughts - happy to chat anytime.

[Jon Emery @JonCEmery]

@tomayates @petedodd24 @Rein_Houben @petermacp I also agree with you about the limitation of using households with no TB cases. A background rate of infection is crucial for estimating relative infectiousness and I'd hope future studies would include some random sampling to improve this measure.

[Jon Emery @JonCEmery]

@petedodd24 @b_frascella @kc_horton @FvLScience @Marks1Guy @alexsrichards @nabilashaikhs @richardwhite321 @Rein_Houben @drhaivnguyen

[Jon Emery @JonCEmery]

Our preprint estimating the infectiousness of subclinical tuberculosis and its contribution to transmission is now out on medRxiv.

https://t.co/do8AlfBsTh

NOT YET PEER REVIEWED

[Jon Emery @JonCEmery]

@petedodd24 @b_frascella @kc_horton @FvLScience @Marks1Guy @alexsrichards @nabilashaikhs @richardwhite321 @Rein_Houben

[Jon Emery @JonCEmery]

@tomayates @Rein_Houben @BolsoverE @dopapus @petedodd24 @ryandinkele @CMLWilliamsUK Great timing Tom. Yes, fingers crossed will be on MedRxiv today or tomorrow. Hope you're keeping well.

[Jon Emery @JonCEmery]

A huge thanks to excellent collaborators @alexsrichards, Katie Dale, @CFMcQuaid, @richardwhite321, @justin_denholm and @Rein_Houben

[Jon Emery @JonCEmery]

The population with a viable Mtb infection may be markedly smaller than generally assumed - new modelling study of Mtb self-clearance out today in Proceedings of the Royal Society B:

https://t.co/OiYPrAycZR

[Anna Coussens @AnnaCoussens]

Are you interested in Subclinical TB and what it means for #AdvancingPrevention? Don't know what all the fuss is about? Have your say at https://t.co/oqTWP4QTHi @StopTB_ETT @Rein_Houben @TomScriba @hanifesmail_tb @JonCEmery @CIDRI_Africa @UnionConference @LSHTM_TB @UCTIDM @FINDdx