jonathan Cools

Cardiothorqcic surgeon, tumor immunologist. Conceptualizing cancer ecologically

[jonathan Cools @JonathanCools]

@builtjustice I mean… Canada has lots of issues I don’t think low taxes are one of them. I think there’s plenty Canada can do before harming the elderly that have paid hand over fist their whole life. Raising taxes more …. I mean what are we paying for

[jonathan Cools @JonathanCools]

@freezing_takes1 @LocasaleLab It’s a target to effect cytotoxicity. So same strategy. That doesn’t mean bad strategy but it’s not new.

[jonathan Cools @JonathanCools]

@john_hersc79276 @LocasaleLab I mean the proof is in a persons reaction to the diagnosis. KM curves really don’t mean anything until it happens to you. 2 things are allowed to be true. This is a good thing but not good enough there’s nothing wrong with that

[jonathan Cools @JonathanCools]

@curiouswavefn I agree with you. During training I had a really talented surgeon scientist tell me that it’s only through rote repetition of the same things over and over again at the beginning that you develop flexibility later on. I’ve found he was very right.

[jonathan Cools @JonathanCools]

@kanair I’ve always wondered what the implication of taking consciousness at face value is. It’s not for anything, it’s experienced. It’s fundamental like time. Is there any discourse along these lines

[jonathan Cools @JonathanCools]

@timgill924 Love it. It’s just put a bit more responsibility on the evaluator. Ai is amazing at stringing words together without saying anything, a skill most people spend a lifetime mastering.

[jonathan Cools @JonathanCools]

@mayukh_panja I think if you don’t change the incentives behind publication, it won’t matter if science lives in academia or the private sector

[jonathan Cools @JonathanCools]

@mbeisen @whydidigetatw Pressure to “produce” in an inherently unpredictable environment means you have to force a narrative to survive. Bad stories have always existed. Ai just makes them sound fancier and exposes apathy in the review process. There is a large element of “popularity”, not just merit

[jonathan Cools @JonathanCools]

@LocasaleLab Yup. We live in a world where two things can never be true at the same time

[jonathan Cools @JonathanCools]

@LocasaleLab Thank you for saying that seriously. Ai has a role in science because science is asking questions. Vapid questions generate vapid answers but the opposite is also true. Good work always took effort with Ai it still does

[jonathan Cools @JonathanCools]

@HenryYin19 I think you speak to a broader problem in science today. It’s tempting to blame individuals, but it’s really a system that rewards metrics and not asking new questions (science). Change the funding paradigm and you’ll change output I think.

[jonathan Cools @JonathanCools]

@mayukh_panja I get your point. I think in everything you get what you give. I mean that honestly, a PhD is a privilege in the sense that you get to study something you deeply care about long enough to be able to pass that knowledge on reliably. That’s what the funny hat and the diploma mean

[jonathan Cools @JonathanCools]

@GlucoXeAlan @arjunrajlab Oh my god thank you. Two independent labs arriving at the same conclusion independently. Large journal: why would we publish that it’s not new ….. it’s just real why would we want to publish something that’s clearly real.

[jonathan Cools @JonathanCools]

@DrNeilStone *ineffective…. Apologies

[jonathan Cools @JonathanCools]

Honestly,this post for someone with you’re level of knowledge is really off. You do a massive disservice to physicians who treat cancer and the patients that experience it. You are touching on the frustration and fear people experience in the face of overall interactive therapy. And the talking down your are showing is why people search for invalid alternatives. Medicines biggest crisis today is good faith honest discussions. It’s ok to be well trained, educated and admit you don’t know. Your job isn’t pushing the fashionable treatment today it’s accompanying someone on an uncertain frightening journey. Your education and experience mandate you know better than this post.

[jonathan Cools @JonathanCools]

@LocasaleLab Gotta say I agree. I mean the real problem is that publishing turned into metric farming instead of sharing ideas and data. The fact is useless data was always useless. But it does make your cv longer so….

[Michael Jain @MichaelDJain]

@Aiims1742 @ItaiYanai @nyulangone @Nature @Perlmutter_CC Interesting, I wonder if this explains the long term “immunologic scar” observed in patients cured of their cancer. Once the non-cancer cells survive the stress of cancer and therapy they “lock in” on a state that is ultimately maladaptive once the cancer is gone. @JonathanCools

[jonathan Cools @JonathanCools]

Agreed but it’s kind of a lie. I mean you don’t know what you don’t know… hence experiments. And this concept of “planning” research is a bit ridiculous at best. Pure fabrication of expected outcomes which is kind of the opposite of science but I do spend a lot of time writing grants

[jonathan Cools @JonathanCools]

@parmita Interesting concept. I like the idea of realtime analysis a lot. We take snapshots to predict the future in biology and that needs to change.