Jonathon Smith

Visiting postdoctoral fellow - Glancy lab of Muscle Energetics, NHLBI, NIH. Interested in all things skeletal muscle.

[Kevin Murach @KevinMurachPhD]

Upcoming Postdoc Position! With Chris Nelson’s lab at U of A, we are looking for a fully supported 2-year postdoc to work on muscle gene editing and detection of gene doping in vivo. If interested, email myself and Chris: [email protected] and [email protected] #myotwitter

[Juleen R. Zierath @JuleenRZierath]

Our latest study connects reduced NR4A3 expression with physical inactivity and indicates that NR4A3 downregulation in human muscle has adverse effects on glucose metabolism and protein synthesis.
Congrats to @JonoSmith01 @DrBMGabriel @NicoPillon & team!

https://t.co/P4B7qZ6L15

[Jonathon Smith @JonoSmith01]

Nice to have our latest up on @biorxivpreprint 🤓 Here we build upon previous work from us (and others) to investigate NR4A3 in the context of skeletal muscle inactivity 🧬 Feedback welcome!

[Juleen R. Zierath @JuleenRZierath]

Latest preprint from our team!

Downregulation of NR4A3 During Inactivity Alters Glucose Metabolism and Impairs Translation in Human Skeletal Muscle

Plus, a new meta-analysis of transcriptomic datasets from human bed rest & limb immobilisation studies!

https://t.co/RCTwO1FM81

[Jonathon Smith @JonoSmith01]

After what feels like the shortest 6 years, I had the pleasure of defending my thesis last week! 🤓 Thanks to @MarcasBamman @EmmaRAndersson @teixeiralabki and @Michael68288255 for great questions and a really fun discussion 🧬 #PhDone

[Juleen R. Zierath @JuleenRZierath]

Dissertation day for Jon Smith! ⁦@JonoSmith01⁩ Jon defends his PhD work on “Skeletal Muscle Responses to Physical Activity in Health and Metabolic Disease” his opponent is Professor Marcas Bamman ⁦@MarcasBamman⁩
Defense is now underway ⁦@karolinskainst⁩

[Jonathon Smith @JonoSmith01]

@HeWaHippo Cheers, Henning! Thanks for kick-starting my interest in the molecular aspects of exercise physiology and skeletal muscle research 🧬

[Jonathon Smith @JonoSmith01]

Nice this work is finally out: “Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase”. See 🧵 from @HeWaHippo 👇

[Henning Wackerhage @HeWaHippo]

So happy that this is finally out now (do not ask why it took this long, it was not the reviewers!). Cancer cells reprogram their energy metabolism to generate substrates for anabolism and we think hypertrophying muscles do the same. More to come! https://t.co/HkOvtbt4ky

[Kevin Murach @KevinMurachPhD]

I really like this comparison of mouse and human muscle by @DyarKen and @JonoSmith01. This is in the supplements of the @NatRevMCB article with @JuleenRZierath. Don’t overlook the bonus coverage! #myotwitter https://t.co/8P4WD0R2lQ

[Jonathon Smith @JonoSmith01]

@JCedernaes @JuleenRZierath Thanks, Jonathan!

[Nature Reviews Molecular Cell Biology @NatRevMCB]

We've just published a tour-de-force Review on the metabolic regulation of skeletal muscle in response to exercise 💪🏼🏃🏾

Fantastic effort by the authors: @JonoSmith01
@KevinMurachPhD @DyarKen @JuleenRZierath

This Review is free to access for 30 days!
https://t.co/ujA6T6aokR

[Jonathon Smith @JonoSmith01]

@HeWaHippo @JuleenRZierath @KevinMurachPhD @DyarKen Thanks, Henning!

[Jonathon Smith @JonoSmith01]

@DrAdamPSharples Thanks, Adam. At least in my mind, complimentary to yours and Brendan’s recent (colossal) Review!

[Jonathon Smith @JonoSmith01]

@lisa_heinke @JuleenRZierath @KevinMurachPhD @DyarKen Thanks, Lisa. Was a really enjoyable experience working with you and the Journal.

[Jonathon Smith @JonoSmith01]

Our ‘Exercise metabolism and adaptation in skeletal muscle’ Review is out in @NatRevMCB! Learnt a lot writing this with @KevinMurachPhD @DyarKen and @JuleenRZierath. Be sure to check out the supp too - good amount of info there that we weren’t able to fit in the main text 🏃‍♀️🏋️ 🧬

[Juleen R. Zierath @JuleenRZierath]

Our latest
Exercise metabolism and adaptation in skeletal muscle | Nature Reviews Molecular Cell Biology
A great collaboration with ⁦@JonoSmith01⁩ ⁦@KevinMurachPhD⁩ ⁦@DyarKen⁩
👍 https://t.co/kruOS8nSk4

[Nicolas J. PILLON @NicoPillon]

No, skeletal #muscle cells do not respond to extracellular #succinate. Makes sense: they don't have the receptor SUCNR1/GPR91! New #research from us @karolinskainst published in @AJPEndoMetab https://t.co/eEr9lnMeFG

[Nicolas J. PILLON @NicoPillon]

Our https://t.co/ysmBXGXd7w database now includes mouse transcriptomics. We hope this will help reduce animal use in research by providing useful data on #exercise responses. Thanks @UtanDjurforsok for the support! #myotwitter

[Juleen R. Zierath @JuleenRZierath]

Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes. @NicoPillon @srp_diabetes
https://t.co/C9nLqbP19F

[Jonathon Smith @JonoSmith01]

Childhood hero. Bumped into him randomly once, on holiday. Took the time to chat to a young fan and aspiring keeper. Meant the world to me. Absolute legend.

RIP #TheGoalie

[Rangers Football Club @RangersFC]

Andy Goram. 1964-2022

💙 The Goalie

[APS Publications @APSPublications]

Last week's most mentioned article is from @AJPEndoMetab:

Three weeks of interrupting #sitting lowers fasting #glucose and glycemic variability, but not glucose tolerance, in free-living women and men with #obesity

https://t.co/yIkPklqlk1

[Juleen R. Zierath @JuleenRZierath]

Our latest: Three wks of interrupting sitting lowers fasting glucose & glycemic variability, but not glucose tolerance, in free-living women & men with obesity ⁦@JonoSmith01⁩ ⁦@MSavikj⁩ ⁦@AJPEndoMetab⁩
https://t.co/hlaj6VRzmB via @NYTimes https://t.co/dC2Lnye6AB

[Avraham Z. Cooper, MD 🩺 @AvrahamCooperMD]

What mitochondrial ATP synthesis actually looks like 😨

#medtwitter