Jonathan Cedernaes

Sleep & circadian researcher, PhD, Medical doctor.
@NorthwesternU & Associate Professor (docent) @UU_University in medical cell biology. Dance aficionado

[Jonathan Cedernaes @JCedernaes]

🧵(1/7) Proud that our new study is finally out after years of work! 🎉

Did you know even short-term #sleep loss 💤 can result in a molecular fingerprint linked to increased future #cardiovascular disease risk? 🫀 ❤️‍🩹 https://t.co/ZcFF9IYpVT

Also timing & #exercise 🏃‍♂️ matter ->

[Nature Aging @NatureAging]

Online now!✨Iiams, Skinner et al explore the effect of early-onset, lifelong time-restricted feeding in >500 male and female mice, and report extended healthspan in male and female mice, and extended lifespan in male mice @SamIiamsClever @CircadianClocks https://t.co/Bno0Mf5tAO

[Society for Research on Biological Rhythms @SRBR_Outreach]

A study published last month in #JBR shows that humans exhibit seasonal changes in sleep, oxygen levels, and respiratory indices. Environmental rhythms and human biology are tightly linked!
https://t.co/9do84PZRv2

[Jacob Gudiol @JacobGudiol]

Ingen borde bli överraskad av det här. Tyvärr är det dock många som tror att det Huberman förmedlar är etablerad vetenskap.

Dr Andrew Huberman gets Fact-checked by MD PhD Doctor - YouTube https://t.co/xvPwrzNDR0

[Eric Topol @EricTopol]

In a randomized trial of a PCSK9 inhibitor [for LDL cholesterol lowering] vs placebo for patients with diabetes and no known heart disease, there was significant reduction of major cardiovascular events including deaths
#ACC26 @JAMA_current
https://t.co/mzuI79c4IN

[Emily Manoogian @EmilyManoogian]

Our collaboration with Dr. Lisa Chow and her team found that TRE (without dietary advice) produced similar outcomes in food and nutrient intake as instructed caloric restriction. https://t.co/JjrO9kIn4a

[NM Endocrinology @NMEndocrinology]

Joseph T. Bass, MD, PhD, joins the Mind & Matter podcast with Host Nick Jikomes to discuss circadian clock mutations and disruptions, hormone rhythms, and weight management.

Listen to the full episode: https://t.co/jVKyv8QQEY

[Jeffrey Iliff @Jeffreyiliff]

Our new study in @NatureComms with Applied Cognition used computational + PK modeling and a 2‑site crossover clinical study to show that during sleep, glymphatic clearance - not synaptic release - drives overnight changes in plasma Aβ and tau in people.
https://t.co/hUhM5OhbJv

[Mark É Czeisler, MD, PhD @MarkCzeisler]

Thank you to Drs @JCedernaes, Bettina Sielaff & Christian Benedict for an aptly named and excellently written Editorial summarizing and contextualizing the study: Time to regularize sleep regularity

https://t.co/oAD5iCtM7t

[Mark É Czeisler, MD, PhD @MarkCzeisler]

The Sleep Regularity Index (SRI) is a strong predictor of health & disease

In SLEEP, we report:
➤📈SRI use
➤>50% non-disclosure of SRI methods
➤Two calculators produced discrepant SRIs

Introducing the Reporting Items for Regularity Indices (RIRI)🧵

https://t.co/2dVdZGoFdr

[Jonathan Cedernaes @JCedernaes]

Congratulations Joe, @JoeBass91471540!! Incredibly well deserved - you're such an amazing scientist, inspiration and mentor.

This is a great recognition for all the pioneering work that Dr. Bass has done in the field of #circadian biology, metabolism and endocrinology.

[Shilatifard Lab @ShilatifardLab]

We are delighted to celebrate the election of our esteemed colleague, Dr. Joe Bass, @JoeBass91471540 to the @theNAMedicine. This honor recognizes his outstanding contributions to the field of Endocrinology, Metabolism, and Molecular Medicine, and his pioneering research elucidating the critical links between the body’s circadian rhythms and metabolic regulation. Dr. Bass’s groundbreaking work has revealed how disruptions in the circadian system contribute to metabolic diseases such as diabetes and obesity. This election represents a well-deserved and long-overdue recognition of Dr. Bass’s exceptional scientific achievements and his profound impact on the field. Congratulations, Joe, on this remarkable and richly merited honor. @NU_BMG_SQE @NUFeinbergMed @theNASciences

[Shilatifard Lab @ShilatifardLab]

We are delighted to celebrate the election of our esteemed colleague, Dr. Joe Bass, @JoeBass91471540 to the @theNAMedicine. This honor recognizes his outstanding contributions to the field of Endocrinology, Metabolism, and Molecular Medicine, and his pioneering research elucidating the critical links between the body’s circadian rhythms and metabolic regulation. Dr. Bass’s groundbreaking work has revealed how disruptions in the circadian system contribute to metabolic diseases such as diabetes and obesity. This election represents a well-deserved and long-overdue recognition of Dr. Bass’s exceptional scientific achievements and his profound impact on the field. Congratulations, Joe, on this remarkable and richly merited honor. @NU_BMG_SQE @NUFeinbergMed @theNASciences

[Sean W Cain @circadian247]

Light at night and heart disease! Published today in JAMA Network Open. We found that those with the brightest nights had higher risks of coronary artery disease, myocardial infarction, heart failure, atrial fibrillation, and stroke.

https://t.co/9sq1KTXSS2

[Society for Research on Biological Rhythms @SRBR_Outreach]

This is great news for the U.S.! While we support abolishment of the biannual switching of the clocks, permanent Standard Time is the better option for our sleep😴, health ⚕️, and even for the safety of our children on the way to school in the mornings 🚍

[Jonathan Cedernaes @JCedernaes]

Thanks for sharing my invited commentary @CircadianClocks 🙏

Regarding the new study by Windred et al on how greater objective #light exposure at night is associated with increased risk of #cardiovascular disease

(n~89000, 8 yrs follow up)

#sleep #myocardialinfarction #stroke

[Joseph Takahashi @CircadianClocks]

Illuminating the Risks of Nighttime Light for Cardiovascular Health https://t.co/UQQcQ7zD5D

[Jonathan Cedernaes @JCedernaes]

The evidence for these is quite weak:
- #melatonin: minor sleep effect, (<8 min.) but ⬆️ quality , *actually* a #circadian hormone
-substandard for recommending magnesium clinically
-no objective (conflicted with subjective) improvements from theanine
-lack of support for others

[Dr. Rhonda Patrick @foundmyfitness]

One of the most common things I'm asked about is sleep supplements.

Here's my list (and why I take them):

�� Melatonin - 3 mg or less 1-3 hours before bed. Best reserved for travel/jet lag or when you *really* need sleep.

• Magnesium glycinate - calms the nervous system especially when stressed (which depletes magnesium). I take 120 mg before bed but some research uses 200-400 mg.

• L-theanine - non-sedating amino acid that helps to calm the brain. A dose of 200-400 mg can improve sleep latency and sleep quality, especially if you're dealing with anxiety/insomnia.

• Glycine - when taken about 30-60 minutes before bed, it may improve subjective sleep quality due to its nervous system effects.

• Myo-inositol - not strongly evidenced as a sleep aid but I've found it helps me calm the "mental chatter" before bed.

[Satchin Panda @SatchinPanda]

Think babies are born without a body clock? ⏰
Not true! By the time they’re born, infants already have a working circadian system that responds to light. Here’s the timeline of how their internal clock develops before birth 👇@LauraKervezee
https://t.co/FBFApoKQbP

[Eric Topol @EricTopol]

How can we reduce the risk of Type 2 diabetes by 31%
A randomized trial of the Mediterranean (MED) diet, weight loss (avg 7 lbs) and moderate exercise vs the MED diet alone
https://t.co/OmRD9SvBDd

[Dr Shawn Baker 🥩 @SBakerMD]

I support this message! The goofy “biological age” tests are largely just a scam perpetuated by those that sell the tests and then subsequent supplements based on the stupid tests

[Today in History @TodayinHistory]

Today in 1945, George Orwell published a devastating critique of Communism.

Animal Farm reveals why every communist revolution follows the same tragic pattern: liberation to corruption to oppression.

Here are 10 truths from Animal Farm Orwell warned us never to forget 🧵👇🏼

[Anshul Kundaje @anshulkundaje]

Utterly uninformed take. We don't know how to pinpoint causal variants accurately for polygenic phenotypes (AD, Diabetes etc.) & good luck editing 100s/1000s of variants in embryos without understanding their pleiotropic effects, oh & ignore those off-target effects.