José Silva & Lab

Reprogramming cells for fun and to create embryo models in the tropical Greater Bay Area. @josesilvalab.bsky.social 🇵🇹🇨🇳🇬🇧

[José Silva & Lab @Jose_Silva_Lab]

Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you.

[Cell @CellCellPress]

In the latest issue! A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells https://t.co/CSYQwEzyha

[PayerLab @PayerLab]

🚨Jobs alert:
Want to join our growing team, working on epigenetics in stem cell models of reproduction and pluripotency?
We are looking for enthusiastic new lab members as part of the Postdoc, PhD, and MSc student recruitment campaign of our centre: https://t.co/hzd9ayiZbV

[Cell Stem Cell @CellStemCell]

Raising the bar for human post-implantation embryo models https://t.co/eiFLMb95nf

[Cell Stem Cell @CellStemCell]

Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling https://t.co/pvpEyeZjt1

[Cell Stem Cell @CellStemCell]

Our October issue is live! The cover highlights several papers reporting advances in stem cell-derived embryo models with a timeline of the rapid development of this field. https://t.co/aGkqvAGN3b

[Seiya Oura @SeiyaO1224]

Honored to see our paper featured on the journal cover! The cover image highlights how the morphological complexity of human stem cell-based embryo models (SCBEMs) has advanced over the past decade.

[ESC & iPSC News @ESC_iPSC_News]

Scientists investigated whether STAT3 activation can reprogram pluripotent stem cells into early fates that self-organize into embryo models.

🔎 Discover their findings in @CellStemCell: https://t.co/mThF80hGHd

[Cell Stem Cell @CellStemCell]

Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling https://t.co/OYi31O6YMc #stemcells

[José Silva & Lab @Jose_Silva_Lab]

(8/8) Our v1.0, limitations remain (see Limitations section), but we hope, alongside other models, it can help advance human embryogenesis research.

Visit our lab website for free access link to our study (under publications section)

[José Silva & Lab @Jose_Silva_Lab]

(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!🙌 Huge thanks to the entire team and our collaborators, special shout-out to Chen Chuanxin (led the work) and Wu Jinyi (computational analysis).
https://t.co/iA9sJw9VIY

[José Silva & Lab @Jose_Silva_Lab]

(7/8) There’s more inside: signaling landscapes, PGCs, primary-to-secondary yolk sac transition…

[José Silva & Lab @Jose_Silva_Lab]

(3/3) Fast forward ⏩ @PandaChuanxin @jywu_wu et al. investigated this in human cells. Curious to see what they pulled off? Stay tuned!

[José Silva & Lab @Jose_Silva_Lab]

(1/3)A while back, my then-PhD student @H_T_Stuart stumbled on a finding that changed our lab’s direction 👀✨. Turns out, STAT3 mediated reprogramming generates intermediates (Gata6GFP+ cells) going through an earlier developmental stage with increased developmental potential 🚀

[José Silva & Lab @Jose_Silva_Lab]

(2/3)… this was actually a side finding in that study🙃
https://t.co/0ULWisHXiU
However, we thought this could be paralleling early embryo development and have since been exploring it to generate embryo models.

[Stem Cell Podcast @stemcellpodcast]

💓 New in @CellCellPress: Researchers at Guangzhou Medical University used #SmallMolecules to convert mouse ESCs into embryo founder cells, which generated a complete embryo model!

Article: https://t.co/x9uV3vVZTe
Episode with discussion: https://t.co/FL9XdBOMOM