Jothi Lab

We make stuff up for living || Chromatin || Transcription || Epigenetics

[Jothi Lab @Jothi_Lab]

Our first animal study! We define a transitional stage between cancer cell dissemination and metastatic outgrowth, providing a framework for investigating biomarkers & therapeutic vulnerabilities during this underexplored phase of metastatic progression. https://t.co/x6sDBZffVo

[Computational Systems Biology Lab @PengyiYang82]

We're thrilled to share our collaborative work with @Jothi_Lab on the human embryo atlas for human blastoid assessment (https://t.co/aP1k3WLRwq). This much-needed work by @hani_jieun provides insights into popular human blastoid models.

[Science girl @sciencegirl]

A fascinating close up of how a bee stinger works

📹 Stated Clearly
https://t.co/i2Xnzs3wcU

[Jothi Lab @Jothi_Lab]

@AdrianoAguzzi This situation reminds me of Stephen Fry's quote: It’s a strange paradox that liberals are illiberal in their demand for liberality, exclusive in their demand for inclusivity, & demand homogeneity/uniformity in their demand for heterogeneity/diversity. And that's a terrible pity

[Jothi Lab @Jothi_Lab]

@TakakuLab Congratulations! We’ll deserved!!

[Jothi Lab @Jothi_Lab]

@BrahmaComplex @UNMC_GCBA @NebraskaMed Congratulations!

[zack chiang @z_chiang]

Confused by all the "what is epigenetics" discourse?

Well I have just the thing for you -- presenting the Epigenetics Alignment Chart!

[Jothi Lab @Jothi_Lab]

@serialChIPer @ChrisGinestier @Emmachadtem @AgenceRecherche Congrats Bruh!

[Jothi Lab @Jothi_Lab]

@chrstn_e Yes, especially if you (A) have published since you last applied &/or (B) are targeting places with a relatively lower profile than the ones you applied to last time. Beware of the survivorship bias in the advice you are getting.

[Sydney Precision Data Science Centre @sydneybioinfo]

What role does the bivalent chromatin play in differentiating stem cells? Dr Dhirendra Kumar from @Jothi_Lab will join us next Monday to present his latest research on the regulatory role of bivalency in maintaining epigenetic plasticity. Joins via zoom. No registration required.

[Jothi Lab @Jothi_Lab]

Postdoc positions available in the Jothi Lab at NIH to study transcriptional and epigenetic control of gene expression programs controlling cell fate decisions. Please RT!

https://t.co/2Z3tT6MMJc

[Karen Fleming @KarenFlemingPhD]

There is a lot of pressure on academics to be extraordinarily successful. Is it worth it?
https://t.co/XkEtWeoGR0

[Marco_Trizzino Lab @marcotrizzino]

My Department at Thomas Jefferson Univ is hiring a new Assistant Prof. (ad coming soon) in any area of Molecular Biology and Biochemistry! It’s a great Department full of nice people with a lot of collaboration opportunities. DM if you have any question and please RT!

[Laura Banaszynski @BanaszynskiLab]

The Banaszynski lab is hiring a postdoc! We are a chromatin lab studying histone variant biology in the context of both development and disease. Help me spread the word and message me if you are interested. 1/

[Jothi Lab @Jothi_Lab]

@meleckmas @GenomeBiology @genomeresearch Supplemental Material can be accessed at https://t.co/oORqfYUcGu

The images are low resolution and a little blotty. Email us if you need high resolution version of this document.

[Jothi Lab @Jothi_Lab]

@meleckmas @GenomeBiology @GenomeResearch will make it available shortly right after the final version is typeset for publication. In the meantime, we can email it if requested. We will also try to make it available on our lab website by the end of the day

[Jothi Lab @Jothi_Lab]

Decoding the function of Bivalent Chromatin in development and cancer. Bivalency does NOT poise genes for rapid activation BUT protects promoters from de novo DNA methylation. Bivalent domains have a function after all!
https://t.co/U63jZBjfBw

[Jothi Lab @Jothi_Lab]

@simonelsasser Thank you very much! We will certainly take a look. Has this data/work been published?

[Jothi Lab @Jothi_Lab]

New insights on the function of bivalent chromatin. Bivalency does NOT poise genes for rapid activation BUT protects reversibly repressed genes from irreversible silencing. ‘Poised’ RNA Pol II incompatible with transcription; H3K4me3 not instructive
https://t.co/mMnouPVdnL

[Jothi Lab @Jothi_Lab]

@benbfly Or maybe I am missing something

[Jothi Lab @Jothi_Lab]

@benbfly (2/2) Since we define poised promoters as those with (promoter-proximal) histones H3 carrying the K4me3 modification, which cannot also be K4me1-modified, I don’t see how K4me1 can directly be over TSS unless the two copies of H3 in a nucleosome are asymmetrically modified