Distal rectal polyp - HPV-associated glandular neoplasms are rare and mimic tubulovillous adenomas. The mucin is peculiar and apical apoptotic bodies can be plentiful (arrow).
Voltaggio L, et al. Mod Pathol. 2020 May;33(5):944-952. PMID: 31857682.
I’m thrilled to share that our study on SMAD4-deficient colorectal adenocarcinoma has just been published in Modern Pathology.
Grateful to my amazing mentor Dr. Oliver G. McDonald for his tremendous support 🙏🏻
@ModernPathology@LizMontgomeryMD@UMiamiPathology#GIPath#PathX
Still my favorite 3D reconstruction of a pancreatic tissue.
Using the CODA workflow, we mapped a billion individual cells in 3D.
Red: pre-cancer lesions
Navy blue: ducts
Light blue: islets of Langerhans
Purple: acini
Green: blood vessels
More here: https://t.co/RsB0RYoPIy
🚨 CAP 2025 Update Highlights! 💥 New recognition of Low HER2 and Ultra-Low HER2 🎯 Refined interpretation for faint/incomplete staining 🧩 Better alignment with targeted HER2 therapies ➡️ HER2 reporting is now more nuanced — every stain matters! #HER2Low#CAPUpdate#BreastPath
These small intestinal biopsies from a patient with markedly elevated serum IgM from a splenic plasmacytoid extranodal marginal zone (mucosa-associated lymphoid tissue) lymphoma show dramatic edema and IgM deposition that resulted in malabsorption. There is no lymphoma.
#GUpath TURBT:
while not a formal urothelial carcinoma subtype (yet!), urothelial carcinoma with myxoid stroma/chordoid features effectively describing same entity with different names:
PMID: 19542871, 19535127
most recently, we've added a series incorporating molecular!⏬
Hi #pathtwitter
Sorry I have been absent, but I have moved jobs!
I am now working in Perth, Australia for Pathwest and (soon for) @uwanews (as A/Prof).
Will get back to posting soon, in the meantime, here is an interesting colleague's case.
#GIpath#Endopath#Pathresidents
High grade Pancreatic Neuroendocrine Neoplasm
Differential diagnosis between PanNET WHO grade 3 and PanNEC
Update from Dr. Singhi #USCAP25#pathology#PathX
Biomarkers vaVIN: (p53 wild type, HPV-Independent VIN) vs benign:
SOX2: Strong basal staining
GATA 3: Loss of expression
SOX17: Diffuse full/partial thickness expression
SOX2 and GATA3 are more specific and SOX17 is more sensitive
Dr. Rakislova #USCAP25#pathology#PathX
Dear Colleagues, have a look at our recent paper describing two cases of prostatic carcinoma and myeloid sarcoma; both myeloid sarcomas were NPM1+! #prostate#myeloidsarcoma#prostatecancer
https://t.co/WjV1lR4LzN
Endometrial carcinoma-Molecular classification
NSMP (non-specific molecular profile) EC group can be separated in two
-Low grade ER positive
-High grade ER negative
Low-grade and ER-positive NSMP ECs are a homogeneous low-risk group associated with an exceptionally favorable prognosis in which de-escalation and/or endocrine therapy strategies can be applied.
Grade 3 and/or ER-negative status identifies a high-risk NSMP subset, including rare high-grade histotypes (eg, clear cell, dedifferentiated, and mesonephric-like), responsible for most NSMP-related deaths https://t.co/sUDhLHGIL5
Dr. Van der Vijer #USCAP25 #pathology #PathX
Urothelial carcinoma - biomarkers:
MMR: do on all upper tract UC
HER2: do, ideally upon request, preferably on metastatic lesions. Use gastric HER2 scoring (DESTINY-PanTumor02 trial)
Dr. Al-Ahmadie #USCPAP25#pathology#PathX
Urothelial carcinoma and MMR testing:
-Urothelial carcinoma is the 3rd most common cancer in Lynch Syndrome patients
-Preferentially develops in upper urinary tract
Dr. Al-Ahmadie #USCAP25#pathology#PathX
Gastric intestinal metaplasia
Complete IM: Well formed goblet cells, enterocytes with well defined brush borders and Paneth cells may be present
Incomplete IM: Goblet cells of variable size, columnar cells with no brush border and no Paneth cells
Extent of IM
Extensive: IM involving at least the corpus
Limited: IM involving only the antrum/incisura
Dr. Ma #USCAP25 #pathology #PathX