JB

HUIS Path

[Guille Martín @Farmaenfurecida]

Alfredo Corell, Catedrático de Inmunología, también le quiere explicar algo a Llorente y Pablo Motos

[Elizabeth Montgomery, MD @LizMontgomeryMD]

Distal rectal polyp - HPV-associated glandular neoplasms are rare and mimic tubulovillous adenomas. The mucin is peculiar and apical apoptotic bodies can be plentiful (arrow).

Voltaggio L, et al. Mod Pathol. 2020 May;33(5):944-952. PMID: 31857682.

[Yasamin Mirzabeigi, MD @YMirzabeigi]

I’m thrilled to share that our study on SMAD4-deficient colorectal adenocarcinoma has just been published in Modern Pathology.

Grateful to my amazing mentor Dr. Oliver G. McDonald for his tremendous support 🙏🏻

@ModernPathology @LizMontgomeryMD @UMiamiPathology

#GIPath #PathX

[Denis Wirtz @deniswirtz]

Still my favorite 3D reconstruction of a pancreatic tissue.

Using the CODA workflow, we mapped a billion individual cells in 3D.

Red: pre-cancer lesions
Navy blue: ducts
Light blue: islets of Langerhans
Purple: acini
Green: blood vessels

More here: https://t.co/RsB0RYoPIy

[Pathology mcqs @Pathology_mcqs]

🚨 CAP 2025 Update Highlights! 💥 New recognition of Low HER2 and Ultra-Low HER2 🎯 Refined interpretation for faint/incomplete staining 🧩 Better alignment with targeted HER2 therapies ➡️ HER2 reporting is now more nuanced — every stain matters! #HER2Low #CAPUpdate #BreastPath

[Ankur Sangoi @slusagar]

when pathologist kills a bx of tumor with wasted #IHCpath stains & now clinical team can't send for NGS

#pathmemes

[CardiovascularCorner @TrackYourHeart]

Kidney tumors

[Elizabeth Montgomery, MD @LizMontgomeryMD]

These small intestinal biopsies from a patient with markedly elevated serum IgM from a splenic plasmacytoid extranodal marginal zone (mucosa-associated lymphoid tissue) lymphoma show dramatic edema and IgM deposition that resulted in malabsorption. There is no lymphoma.

[Janira Navarro @Janiranavarro]

S100 positive mesenchymal neoplasms

Dr. Fritchie- Comprehensive and Immersive Soft Tissue Pathology Course-May 2025 #pathology #BSTPath #PathX

[Ankur Sangoi @slusagar]

#GUpath TURBT:

while not a formal urothelial carcinoma subtype (yet!), urothelial carcinoma with myxoid stroma/chordoid features effectively describing same entity with different names:
PMID: 19542871, 19535127

most recently, we've added a series incorporating molecular!⏬

[Janira Navarro @Janiranavarro]

Hepatocellular Carcinoma
CDX2 and SATB2 expression does not exclude HCC
Use a panel

Dr. Chandan #USCAP25 #pathology #PathX

[Tristan Rutland MBBS FRCPA IFCAP @TristanRutland7]

Hi #pathtwitter

Sorry I have been absent, but I have moved jobs!

I am now working in Perth, Australia for Pathwest and (soon for) @uwanews (as A/Prof).

Will get back to posting soon, in the meantime, here is an interesting colleague's case.

#GIpath #Endopath #Pathresidents

[Janira Navarro @Janiranavarro]

High grade Pancreatic Neuroendocrine Neoplasm
Differential diagnosis between PanNET WHO grade 3 and PanNEC

Update from Dr. Singhi #USCAP25 #pathology #PathX

[Janira Navarro @Janiranavarro]

Biomarkers vaVIN: (p53 wild type, HPV-Independent VIN) vs benign:

SOX2: Strong basal staining
GATA 3: Loss of expression
SOX17: Diffuse full/partial thickness expression
SOX2 and GATA3 are more specific and SOX17 is more sensitive

Dr. Rakislova #USCAP25 #pathology #PathX

[Ankur Sangoi @slusagar]

PMID: 39305965

DOI: 10.1016/j.humpath.2024.105667

[Judith Ferry @judith_ferry]

Dear Colleagues, have a look at our recent paper describing two cases of prostatic carcinoma and myeloid sarcoma; both myeloid sarcomas were NPM1+! #prostate #myeloidsarcoma
#prostatecancer

https://t.co/WjV1lR4LzN

[Janira Navarro @Janiranavarro]

Endometrial carcinoma-Molecular classification
NSMP (non-specific molecular profile) EC group can be separated in two
-Low grade ER positive
-High grade ER negative

Low-grade and ER-positive NSMP ECs are a homogeneous low-risk group associated with an exceptionally favorable prognosis in which de-escalation and/or endocrine therapy strategies can be applied.
Grade 3 and/or ER-negative status identifies a high-risk NSMP subset, including rare high-grade histotypes (eg, clear cell, dedifferentiated, and mesonephric-like), responsible for most NSMP-related deaths https://t.co/sUDhLHGIL5

Dr. Van der Vijer #USCAP25 #pathology #PathX

[Janira Navarro @Janiranavarro]

Urothelial carcinoma - biomarkers:
MMR: do on all upper tract UC
HER2: do, ideally upon request, preferably on metastatic lesions. Use gastric HER2 scoring (DESTINY-PanTumor02 trial)

Dr. Al-Ahmadie #USCPAP25 #pathology #PathX

[Janira Navarro @Janiranavarro]

Urothelial carcinoma and MMR testing:
-Urothelial carcinoma is the 3rd most common cancer in Lynch Syndrome patients
-Preferentially develops in upper urinary tract

Dr. Al-Ahmadie #USCAP25 #pathology #PathX

[Janira Navarro @Janiranavarro]

Gastric intestinal metaplasia
Complete IM: Well formed goblet cells, enterocytes with well defined brush borders and Paneth cells may be present
Incomplete IM: Goblet cells of variable size, columnar cells with no brush border and no Paneth cells

Extent of IM
Extensive: IM involving at least the corpus
Limited: IM involving only the antrum/incisura

Dr. Ma #USCAP25 #pathology #PathX