Jun Qi Lab

Chemical Biology lab @HarvardMed and @DanaFarber. We use a multidisciplinary approach to study biological roles of epigenetic proteins & transcription factors.

[Jun Qi Lab @JunQiLab]

What a remarkable scientist, compassionate physician and inspiring innovator. @FilbinMariella congratulations on your outstanding work.

[Dana-Farber @DanaFarber]

@FilbinMariella, MD, PhD, studies childhood brain cancers by directly studying the tumors of the patients she treats. By understanding the biology of these cancers, she is discovering new strategies to treat them. Learn more about her work here: https://t.co/pjRseQ4vGp

[Jun Qi Lab @JunQiLab]

Our support page set up now @AlexsLemonade @TheVFoundation @StBaldricks @bcutd_research @EpendymomaRF @IronMattLarson @curingcancer.

https://t.co/12qJrPLgrf

Your support is essential for our cancer research. Please support our cancer research.

https://t.co/3wy9UuF0o9

[Jun Qi Lab @JunQiLab]

Thank you for featuring our collaborative work.

[Science in Boston @ScienceinBoston]

A new study from @DanaFarber reports the first potent and selective compound to target IRF4 and validates degradation of IRF4 as a potential approach to the treatment of #MultipleMyeloma.

🔎 See the abstract from Drs. @JunQiLab and @IrenemGhobrial: https://t.co/XztBqvmRLt

[Jun Qi Lab @JunQiLab]

We also like to thank @AlexsLemonade @StBaldricks @EpendymomaRF @sontagfdn @IronMattLarson @curingcancer @sontagfdn @TheVFoundation and more... for their support and helping us build the drug discovery capability for pediatric brain tumor.

[Jun Qi Lab @JunQiLab]

Thrilled to share our collaborative work with @FilbinMariella, now online in Neuro-Oncology! We identify HDAC2 as a tractable target for H3K27M DMG growth in vitro and in vivo. Congrats to @JunQiLab and @FilbinMariella — excited for more to come together!
https://t.co/s7wx4fwcxR

[Jun Qi Lab @JunQiLab]

Thrilled to share our collaborative work with @FilbinMariella, now online in Neuro-Oncology! We identify HDAC2 as a tractable target for H3K27M DMG growth in vitro and in vivo. Congrats to @JunQiLab and @FilbinMariella — excited for more to come together!
https://t.co/s7wx4fwcxR

[Jun Qi Lab @JunQiLab]

Our study demonstrated that IRF4 can be chemically targeted. Our approach can be further developed into novel therapy for multiple myeloma.
https://t.co/oy60hATb5a
Please support our drug discovery effort for high risk tagets @JunQiLab at @DanaFarber. https://t.co/3wy9UuF0o9

[Jun Qi Lab @JunQiLab]

@10mM_Mike what a journey. Congratulations!

[Jun Qi Lab @JunQiLab]

Our collaborative work with @IrenemGhobrial on targeting transcription factor IRF4 is now online @nchembio. It is so exciting that we discovered an IRF4 binder & a selective IRF4 degrader that can interrupt MM cell growth. Congrats @10mM_Mike & all authors https://t.co/RJFu6wqJsU

[Jun Qi Lab @JunQiLab]

@sciqst @MolMetab Yes, with the multiple targets and pathways we identified, they are all can be targets for novel therapy development.

[Jun Qi Lab @JunQiLab]

Our collaborative study with Dr. Qiong Duan on histone acetylation regulated energy storage is now published @MolMetab. We established more understanding on how "active" acetylation vs "passive" acetylation balanced each other at different states. https://t.co/p7c8jju8vw

[Jun Qi Lab @JunQiLab]

Thank you @StBaldricks for highlight our research on studying natural compound in DMG with Prof. Movassaghi @ChemistryMIT and @FilbinMariella. Thank you so much for your support @StBaldricks

[St. Baldrick's Foundation @StBaldricks]

Hope is powerful. Research is lifesaving. 🙏

Your support helps fund groundbreaking discoveries for children battling cancer.

Read how it’s making a difference in our latest edition of Research Outcomes: https://t.co/1ZhjvSdu8A

[Jun Qi Lab @JunQiLab]

With better understanding of proteosome machinery, hopefully, we can come up more and more cool idea to utilize the system for novel therapy development.

[Dana-Farber News @DanaFarberNews]

New research in @angew_chem by @DanaFarber’s @JunQiLab reveals a novel chemical biology approach to achieving selective targeted protein degradation using proteosome cap region proteins directly in addition to the current PROTAC strategy, which could aid in developing therapies and cancer drugs.

➡️ https://t.co/yoRfR5X0Tv

[Jun Qi Lab @JunQiLab]

It was such a fun day to visit ⁦@PennMedicine⁩ and talk about science with ⁦@junwei_s⁩ ⁦@LilingWanLab⁩ and present our science. Thank you for having me.

[Jun Qi Lab @JunQiLab]

Our work using cap region proteins of proteosome to directly induce targeted protein degradation is now published online @angew_chem. Congratulations to all the authors on bringing this to the finish line. Thanks @BloodCancerUtd for supporting our work.
https://t.co/wy8BZ5wRWv

[Jun Qi Lab @JunQiLab]

We would like to thank the support from @EpendymomaRF, @curingkidsckc and @StBaldricks that allow us to build our biology capability to explore novel therapeutic options for pediatric brain cancer.

[Jun Qi Lab @JunQiLab]

Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. https://t.co/xSz7D7tTAW

[Jun Qi Lab @JunQiLab]

I am thrilled to work and publish together with my postdoc PI, Prof. Mo Movassaghi @ChemistryMIT to bring their sophisticated chemistry to potential therapy development. I am excited to keep learning from Mo and @FilbinMariella. Pic from: https://t.co/rFGOAqxkBE

[Jun Qi Lab @JunQiLab]

Our collaborative work with Prof. Mo Movassaghi at @chemistryMIT and @FilbinMariella is now online @acsJACS @ACSPublications. Thrilled to work as chemical biology part to explore therapeutic potential of these awesome nature compounds from Mo's lab. https://t.co/xSz7D7tTAW

[Jun Qi Lab @JunQiLab]

This is absolutely fun!!! @LabSethi cannot wait to do more together. To create more and better understanding in cancers and find potential novel therapy together. @AGA_Gastro

[Sethi_Lab @LabSethi]

Can we have a biotinylated and inactive version of the HDAC1/2 inhibitor? How do you do Chem-seq, Jun? In the end, we were able to follow our observations and publish these findings thanks to collaborative science fostered by @DanaFarber @DanaFarberNews

[Jun Qi Lab @JunQiLab]

It is so exciting to see the final version of our collaborative work with @LabSethi. We found that blocking HDAC1/2 pushes CRC cells out of a stem-like state and into differentiation. We will work tother more to find novel therapeutic options for CRC. https://t.co/VGfazP6PeG

[Jun Qi Lab @JunQiLab]

@rosslevinemd congratulations. such a well-deserved recognition!!!!