Jun Qi Lab

Chemical Biology lab @HarvardMed and @DanaFarber. We use a multidisciplinary approach to study biological roles of epigenetic proteins & transcription factors.

[Jun Qi Lab @JunQiLab]

@masonbgrant @DanaFarberNews @JExpMed @DanaFarber i know Allison. Please send me an email to my Farber Email.

[Jun Qi Lab @JunQiLab]

@masonbgrant @DanaFarberNews @JExpMed @DanaFarber We don't have any access to these cell lines. if you know anyone studying this, we will be more than happy to share and collaborate.

[Jun Qi Lab @JunQiLab]

@DanaFarberNews @DanaFarber @KathleenHBurns @theNAMedicine @KStegmaier_DFCI congratulations!!!!

[Jun Qi Lab @JunQiLab]

Thank you, @ADurbinLab. It is fascinating to learn more cancer biology together with you and your team. We will work together to find the cures for pediatric cancers. Thanks for @curingcancer @AlexsLemonade @TheVFoundation for all the support.

[Adam Durbin @ADurbinLab]

So excited to work with @JunQiLab on this important study!

[Jun Qi Lab @JunQiLab]

It is so exciting to build the understanding of the function differences between EP300 and CBP, which can be applied to target specific therapy development.

[Adam Durbin @ADurbinLab]

This was a major effort between the @Adurbinlab @TheAbraLab @JunQiLab and the Ory labs. We pick up on a long-term interest of our labs: the attractive target, EP300. EP300 is a great cancer target because while many tumor cells require it, they often may not need its paralog CBP

[Jun Qi Lab @JunQiLab]

So exciting to have this paper online @JExpMed . thanks for the wonderful collaboration with @ADurbinLab @TheAbraLab, Ory lab. Congratulations on all the team members.

[Journal of Experimental Medicine @JExpMed]

The first authors are: Ian M. Delahunty, Stephanie Nance, Yang Zhang, François Lamoureux, and Qi Liu.

From Ory lab @NantesUniv, @JunQiLab @DanaFarber, @TheAbraLab, and @ADurbinLab @MolOnc_StJude @StJudeResearch @StJudegraduate

[Jun Qi Lab @JunQiLab]

@LabSethi @jclinicalinvest Congratulations!!!!

[Jun Qi Lab @JunQiLab]

What a remarkable scientist, compassionate physician and inspiring innovator. @FilbinMariella congratulations on your outstanding work.

[Dana-Farber @DanaFarber]

@FilbinMariella, MD, PhD, studies childhood brain cancers by directly studying the tumors of the patients she treats. By understanding the biology of these cancers, she is discovering new strategies to treat them. Learn more about her work here: https://t.co/pjRseQ4vGp

[Jun Qi Lab @JunQiLab]

Our support page set up now @AlexsLemonade @TheVFoundation @StBaldricks @bcutd_research @EpendymomaRF @IronMattLarson @curingcancer.

https://t.co/12qJrPLgrf

Your support is essential for our cancer research. Please support our cancer research.

https://t.co/3wy9UuF0o9

[Jun Qi Lab @JunQiLab]

Thank you for featuring our collaborative work.

[Science in Boston @ScienceinBoston]

A new study from @DanaFarber reports the first potent and selective compound to target IRF4 and validates degradation of IRF4 as a potential approach to the treatment of #MultipleMyeloma.

🔎 See the abstract from Drs. @JunQiLab and @IrenemGhobrial: https://t.co/XztBqvmRLt

[Jun Qi Lab @JunQiLab]

We also like to thank @AlexsLemonade @StBaldricks @EpendymomaRF @sontagfdn @IronMattLarson @curingcancer @sontagfdn @TheVFoundation and more... for their support and helping us build the drug discovery capability for pediatric brain tumor.

[Jun Qi Lab @JunQiLab]

Thrilled to share our collaborative work with @FilbinMariella, now online in Neuro-Oncology! We identify HDAC2 as a tractable target for H3K27M DMG growth in vitro and in vivo. Congrats to @JunQiLab and @FilbinMariella — excited for more to come together!
https://t.co/s7wx4fwcxR

[Jun Qi Lab @JunQiLab]

Thrilled to share our collaborative work with @FilbinMariella, now online in Neuro-Oncology! We identify HDAC2 as a tractable target for H3K27M DMG growth in vitro and in vivo. Congrats to @JunQiLab and @FilbinMariella — excited for more to come together!
https://t.co/s7wx4fwcxR

[Jun Qi Lab @JunQiLab]

Our study demonstrated that IRF4 can be chemically targeted. Our approach can be further developed into novel therapy for multiple myeloma.
https://t.co/oy60hATb5a
Please support our drug discovery effort for high risk tagets @JunQiLab at @DanaFarber. https://t.co/3wy9UuF0o9

[Jun Qi Lab @JunQiLab]

@10mM_Mike what a journey. Congratulations!

[Jun Qi Lab @JunQiLab]

Our collaborative work with @IrenemGhobrial on targeting transcription factor IRF4 is now online @nchembio. It is so exciting that we discovered an IRF4 binder & a selective IRF4 degrader that can interrupt MM cell growth. Congrats @10mM_Mike & all authors https://t.co/RJFu6wqJsU

[Jun Qi Lab @JunQiLab]

@sciqst @MolMetab Yes, with the multiple targets and pathways we identified, they are all can be targets for novel therapy development.

[Jun Qi Lab @JunQiLab]

Our collaborative study with Dr. Qiong Duan on histone acetylation regulated energy storage is now published @MolMetab. We established more understanding on how "active" acetylation vs "passive" acetylation balanced each other at different states. https://t.co/p7c8jju8vw

[Jun Qi Lab @JunQiLab]

Thank you @StBaldricks for highlight our research on studying natural compound in DMG with Prof. Movassaghi @ChemistryMIT and @FilbinMariella. Thank you so much for your support @StBaldricks

[St. Baldrick's Foundation @StBaldricks]

Hope is powerful. Research is lifesaving. 🙏

Your support helps fund groundbreaking discoveries for children battling cancer.

Read how it’s making a difference in our latest edition of Research Outcomes: https://t.co/1ZhjvSdu8A

[Jun Qi Lab @JunQiLab]

With better understanding of proteosome machinery, hopefully, we can come up more and more cool idea to utilize the system for novel therapy development.

[Dana-Farber News @DanaFarberNews]

New research in @angew_chem by @DanaFarber’s @JunQiLab reveals a novel chemical biology approach to achieving selective targeted protein degradation using proteosome cap region proteins directly in addition to the current PROTAC strategy, which could aid in developing therapies and cancer drugs.

➡️ https://t.co/yoRfR5X0Tv

[Jun Qi Lab @JunQiLab]

It was such a fun day to visit ⁦@PennMedicine⁩ and talk about science with ⁦@junwei_s⁩ ⁦@LilingWanLab⁩ and present our science. Thank you for having me.