Sethi_Lab

Dedicated physicians & scientists determined to improve outcomes in patients with gastrointestinal cancers through basic and translational research @DanaFarber

[Yale Cancer Center @YaleCancer]

Congratulations to @MuzumdarLab and @SStevenWang, recipients of an @theNCI #R33 award, which they will use to develop #RAEFISH, an innovative spatial transcriptomics technology.
https://t.co/zxq1eiYV9E
@SmilowCancer @YaleGenetics

[Jun Qi Lab @JunQiLab]

It is so exciting to build the understanding of the function differences between EP300 and CBP, which can be applied to target specific therapy development.

[Peggy Hsu MD PhD @PeggyPHsu]

Interested in studying the origins of lung cancer and regulation of development, cell fate, metabolism in human lung progenitors? All in a rigorous, science-loving, supportive environment?

I'm looking for postdoctoral fellows, students, technicians! DM me.

Please retweet!

[OncoDaily GI @OncoDailyGI]

A New Era for Colorectal Cancer Care at MD Anderson - Scott Kopetz

@skopetz

https://t.co/GP1MMT9MNg

[Sethi_Lab @LabSethi]

Beautiful study by the @Oser_Lab! Crispr screen applied to custom reporter revealed HUWE1 is a stability regulator or ASCL1, lineage TF driving a major subtype of SCLC. Then base editor screens identify functional domains, including an uncharacterized IDR. Elegant and rigorous!

[OserLab @Oser_Lab]

Excited to share another new study from our lab, co-led by Keita Masuzawa and Kevin Dong: “A HUWE1 Regulatory Helix Gates ASCL1 Degradation Through Its C-Terminal Phospho-Degron in Small Cell Lung Cancer.”

https://t.co/SLhbNOAek3

[Sethi_Lab @LabSethi]

We appreciate the support from @DanaFarber and are grateful to the patients who participated.

[Dana-Farber News @DanaFarberNews]

A new study in @jclinicalinvest led by @danafarber’s @labsethi sheds light on therapy-associated polyposis, a rare condition that can develop decades after cancer treatment in childhood or young adulthood. For the first time, researchers identified lasting molecular evidence of genetic damage linked to chemotherapy in precancerous colorectal growths.

Read more here: https://t.co/2xt7jYQKSt

[Sethi_Lab @LabSethi]

@Oser_Lab Amazing, looking forward to reading Matt!

[Sethi_Lab @LabSethi]

@JunQiLab @jclinicalinvest Thanks Jun!

[Sethi_Lab @LabSethi]

Our work on therapy-associated polyposis highlighted below by @jclinicalinvest . In childhood cancer survivors, we find that prior alkylating chemotherapy can leave durable mutational scars in the colon that remain detectable decades later in precancerous polyps.

[Journal of Clinical Investigation @jclinicalinvest]

Therapy-associated polyposis (TAP) is a rare condition that arises decades after treatment for childhood and young adult cancers. https://t.co/EWicYaiu8q
In this Research Letter, Nilay S. Sethi @Nilay_Sethi & team reveal a mutational signature strongly linked to alkylating chemotherapy exposure in childhood cancer survivors, reporting chemotherapy leaves lasting DNA scars in precancerous colon polyps. Paired patient organoids establish an experimental model for further studies.
@labsethi @DanaFarber
#ChildhoodCancer

[Sethi_Lab @LabSethi]

@srviswanathan @jclinicalinvest Thanks Srini!

[Sethi_Lab @LabSethi]

Great collaboration with @SwagataGoswam16, @ohyilmaz , and colleagues

[Sethi_Lab @LabSethi]

Increased dietary fats leads to more aggressive colorectal cancer via ceramide synthesis and YAP regenerative signaling. A metabolic memory of the exposure persists. https://t.co/Ns1qJBRUQc

[Sethi_Lab @LabSethi]

Great collaboration with @ohyilmaz, @SwagataGoswam16, and colleagues!

[Sethi_Lab @LabSethi]

Grateful to the patients, collaborators, and team who made this study possible. @MattYurgelun

#ChildhoodCancer #CancerSurvivorship #ColorectalCancer #polyposis

[Dana-Farber News @DanaFarberNews]

Congratulations to @DanaFarber’s @nickpolizzi_ and @XinGu0317 who have received New Innovator Awards from the @NIH High-Risk, High-Reward Research program which supports early career investigators pursuing highly innovative research with potential for broad impact on biomedical and behavioral science. @DFCI_CancerBio

Read more: https://t.co/jZ0YLbv6CA

[Waggoner Lab @LabWaggoner]

Exposure to high dietary fat increases ceramides and promotes cancer metastasis @ScienceMagazine @SwagataGoswam16 @EinsteinMed @ohyilmaz @Nilay_Sethi @DanaFarber
https://t.co/lBXsnK7tb8

[OncoDaily GI @OncoDailyGI]

How Dietary Lipids Can Shape Colorectal Cancer Cell Behavior? - Swagata Goswami (@SwagataGoswam16)

https://t.co/wHYu9CGE5N

[Sethi_Lab @LabSethi]

@SStevenWang @RoswellPark Wonderful Steven!

[Sethi_Lab @LabSethi]

A wonderful study to be part of. Thanks for including us @ohyilmaz!

[Omer Yilmaz @ohyilmaz]

What gives some colorectal cancer cells the ability to metastasize? In our new paper, we find that tumor-intrinsic ceramide synthesis is a metabolic switch for metastatic initiation. 🧵 Free access: https://t.co/Yh5WLKzZoC

[Swagata Goswami @SwagataGoswam16]

Now out in @ScienceMagazine! What gives some colorectal cancer cells the ability to spread? We found that ceramides made by cancer cells help activate a reparative program to metastasize.
@qiming_kelly @ohyilmaz @Aslan_Tasdogan @UpasanaDA @aburakyildiz
https://t.co/UneYxGmkbU