📢 Excited to share our new paper in @Gut_BMJ! We uncover the TNF‑α/ULBP/NKG2D axis that amplifies microvascular damage in Severe Acute Pancreatitis, a disease with high mortality. Promising therapeutic target!
🔗[https://t.co/81ey19gpfz]
#Gastroenterology#Pancreatology#SAP
Determining "over-correction" of single-cell data integration is an unmet need. We found the stably expressed "housekeeping genes" can be used to identify over-correction, our RBET tool can provide assurance for multi-omics research with big integration.
https://t.co/rD0gNDs1YC
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
https://t.co/v7tmCPF8pd
Butyrate produced by gut bacteria is known to play key roles for cancer prevention by regulating cancer&immune cells. We identified a novel butyrate target, namely SULF1+ cancer-associated fibroblasts, which promote colorectal cancer progression. @CR_AACR https://t.co/je9V8Gp81p
Our recent study identified RIPK2, which mediates MHC-I degradation, as a promising immunotherapy target for pancreatic cancer. #PDAC Power of CRISPR screening and single-cell analysis, happy collaboration with YH Liu, D Wang and H Jiang #Cancer_Discovery https://t.co/5hVxsu8rkZ
OnlineFirst:
Receptor-interacting Protein Kinase 2 Is an #Immunotherapy Target in #PancreaticCancer, by Wenhua Sang, Yiduo Zhou, Haiyan Chen, Chengxuan Yu, @jiangh7, Junbin Qian, Da Wang, Yun-Hua Liu et al.
https://t.co/YLsC5KSEIQ
@ZJU_China
Check out our latest story on how we use single-cell data to discover novel stromal cell phenotypes prognostic for ovarian cancer patients ! Collaborative effort with olbrecht & Vergote @UZLeuven
Why not all breast cancer patients respond to immunotherapy? Check out our latest dataset showing single-cell immune dynamics after a single-dose of anti-PD1 treatment, various phenotypes and biomarkers associated with T cell expansion. Thanks to @LambrechtsDlab & collaborators!
Transcriptomic and proteomic profiling of #breastcancer biopsies identifies baseline features of the tumor immune microenvironment associated with T cell clonal expansion following neoadjuvant anti-PD-1 treatment.
https://t.co/pSPnK2doR4 #THPT21@LambrechtsDlab@vib_ccb
Our dataset of dynamic changes in immune cells at single-level in breast cancer receiving anti-PD1 treatment is out now. Thanks to our collaborators @UZLeuven, and totally convinced these findings will have impact on cancer patients. @VIBLifeSciences@KU_Leuven