Junbin Qian

MD PhD, Research Professor. Chromosomal instability, tumor microenvironment and their therapeutic targeting across cancer types.

[Junbin Qian @JunbinQian]

📢 Excited to share our new paper in @Gut_BMJ! We uncover the TNF‑α/ULBP/NKG2D axis that amplifies microvascular damage in Severe Acute Pancreatitis, a disease with high mortality. Promising therapeutic target!
🔗[https://t.co/81ey19gpfz]
#Gastroenterology #Pancreatology #SAP

[Junbin Qian @JunbinQian]

Determining "over-correction" of single-cell data integration is an unmet need. We found the stably expressed "housekeeping genes" can be used to identify over-correction, our RBET tool can provide assurance for multi-omics research with big integration.
https://t.co/rD0gNDs1YC

[Adrian Saurin @AdeSaurin]

Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.

https://t.co/v7tmCPF8pd

[Junbin Qian @JunbinQian]

@SteSantaguida @ScienceMagazine Great work, very inspiring!

[Junbin Qian @JunbinQian]

Butyrate produced by gut bacteria is known to play key roles for cancer prevention by regulating cancer&immune cells. We identified a novel butyrate target, namely SULF1+ cancer-associated fibroblasts, which promote colorectal cancer progression. @CR_AACR https://t.co/je9V8Gp81p

[Junbin Qian @JunbinQian]

Our recent study identified RIPK2, which mediates MHC-I degradation, as a promising immunotherapy target for pancreatic cancer. #PDAC Power of CRISPR screening and single-cell analysis, happy collaboration with YH Liu, D Wang and H Jiang #Cancer_Discovery https://t.co/5hVxsu8rkZ

[Cancer Discovery @CD_AACR]

OnlineFirst:
Receptor-interacting Protein Kinase 2 Is an #Immunotherapy Target in #PancreaticCancer, by Wenhua Sang, Yiduo Zhou, Haiyan Chen, Chengxuan Yu, @jiangh7, Junbin Qian, Da Wang, Yun-Hua Liu et al.
https://t.co/YLsC5KSEIQ
@ZJU_China

[Junbin Qian @JunbinQian]

@vincentpasque @CellStemCell Hi Vincent that is super cool, congratulations!

[@DiLa_lab @LambrechtsDlab]

Check out our latest story on how we use single-cell data to discover novel stromal cell phenotypes prognostic for ovarian cancer patients ! Collaborative effort with olbrecht & Vergote @UZLeuven

[Junbin Qian @JunbinQian]

@AibinHe Great application,cannot wait to read.

[Junbin Qian @JunbinQian]

@TiroshLab Fantastic solution!!!

[Laurien Van Dyck (she/her) @VanDyckLaurien]

Proud to present our blog for @NatureMedicine🙌
Curious for the inside-story behind this great publication, through the eyes of 3 PhD students (@BassezAyse, Hanne Vos and me)?
@VIBLifeSciences @UZLeuven @KU_Leuven @CHG_CME @FWOVlaanderen @LambrechtsDlab
https://t.co/z8ZkyavnGP

[Junbin Qian @JunbinQian]

@AibinHe @naturemethods @scell_papers @epigen_papers Fantastic tool, big congrats!!!

[Junbin Qian @JunbinQian]

@AndreaMusacchi1 a time when news provides a story and many links, but don't care if readers click

[Junbin Qian @JunbinQian]

@AdeSaurin @LambrechtsDlab Thanks Adrian, I am really lucky to be in a flying team :)

[Junbin Qian @JunbinQian]

Why not all breast cancer patients respond to immunotherapy? Check out our latest dataset showing single-cell immune dynamics after a single-dose of anti-PD1 treatment, various phenotypes and biomarkers associated with T cell expansion. Thanks to @LambrechtsDlab & collaborators!

[Nature Medicine @NatureMedicine]

Transcriptomic and proteomic profiling of #breastcancer biopsies identifies baseline features of the tumor immune microenvironment associated with T cell clonal expansion following neoadjuvant anti-PD-1 treatment.

https://t.co/pSPnK2doR4 #THPT21 @LambrechtsDlab @vib_ccb

[Junbin Qian @JunbinQian]

@LGMartelotto @dvbro0 thank you :)

[@DiLa_lab @LambrechtsDlab]

Our dataset of dynamic changes in immune cells at single-level in breast cancer receiving anti-PD1 treatment is out now. Thanks to our collaborators @UZLeuven, and totally convinced these findings will have impact on cancer patients. @VIBLifeSciences @KU_Leuven

[Junbin Qian @JunbinQian]

@LGMartelotto @dvbro0 Too attractive, could I also have one?

[@DiLa_lab @LambrechtsDlab]

#worldcancerday2021 Big thanks to all our funding sources to support our cancer research! @VIBLifeSciences @KU_Leuven @FWOVlaanderen @ERC_Research @IMI_JU @Samen_tg_Kanker @komop_tgkanker @EU_H2020 @hrbireland @Agilent @ERALEARN_EU @VLAIO_be