Brian, for the love of god, you cannot take a health database, click 'sort' and think that the top 5 drugs patients who survive longer happen to be taking are causal to the benefit those patients received. 500k is actually not a large cohort for a database, needs alpha correction, was very unlikely to be prespecified, etc. that's why no one is impressed with these studies and they're published in trash journals.
this study showed a slight increase in CV events with PDEs vs placebo
https://t.co/y3AbyTFHUU
the mechanistic rationale is not there and your explanation is terrible. ALL PDEs metabolize cAMP/cGMP, thats why they are phosphodiesterases. are you suggesting we should inhibit all PDEs?!
by the same logic we should all be taking ERAs too. why not ARBs and ACEs? screw it i'll take inhaled treprostinil too. might extend my life. then i'll run SQL queries on health databases until i see a 'signal', bonferroni may roll in his grave but i will be vasodilated.
The man running the agency responsible for 340 million Americans' health arrives at 10am, leaves by 4pm, skips his own division chief meetings, and when he does show up - scrolls his phone and gets described by colleagues as "checked out."
Ebola is spreading. Six Americans already exposed. He has not briefed himself with CDC scientists. His response to a reporter asking if he was worried: "Yeah, we're working on it."
The CDC is being run by a health economist with no public health experience who already has another full-time job running NIH. Half of the 27 NIH institutes have no permanent director. The top FDA drug regulator got fired in May - Kennedy found out after it happened.
When measles killed two children in Texas, the CDC official leading the response asked repeatedly to brief Kennedy. He was rebuffed every time.
The person actually running HHS operations is a longtime personal adviser whose policy spreadsheet - more than 50 items - is hidden from the department's own policy team. When Kennedy gets asked a question, his standing answer is "just run that by Stefanie."
This is not a management philosophy. This is a vacancy wearing a title.
Thomas Massie delivers the truth about the intentional Israeli attack against the USS Liberty on the House Floor on the 59th year anniversary of the attack and calls for a real investigation.
He says there was a 17-hour delay in receiving help after they were under attack by Israel.
“It was intentional murder by the state of Israel.”
“The Israelis were intent to leave no survivors.”
“This was an effort to kill everyone on board.”
@mendietaalex1 No tx, as asymptomatic bacteria is not treated unless pt is preg and treating unnecessarily can cause more harm then good IE side effects/c diff/etc
@DickFromKansas@drvonraapalje@FabioChianelli TF are we doing here? Every month model is shiftd based on what’s hot in the headlines. Always gonna be a step behind. Stick to something and deliver. Where’s the royalties? The trials/data? All these years with minimal to show for it. At least show some confidence with Ins buys
@mandyarthur@realDonaldTrump Rep. Thomas Massie. He consistently votes to uphold limited government, individual rights, and constitutional constraints on federal power, often against both parties.
@drvonraapalje@FabioChianelli Preach! Have held a substantial position since 2020. So much potential but nothing of substance in a long time. Provide us with royalties/updated milestones, insider buys, updates on clinical trials, anything worth getting excited about.
After months of beating around the bush, one reporter finally writes the true story of my race and when asked, the lobbyists brag about it.
A coalition of Israel’s lobbyists and donors is spending tens of millions of dollars in a blatant attempt to buy a KY congressional seat.
We don't have a cure for Alzheimers because it's a difficult scientific problem
Not because of corruption
And if we did find a cure, RFK would denounce it as a Big Pharma scam