Kannan Lab ESBG

Evolutionary Systems Biology Group at UGA. We combine bioinformatics and biochemistry to uncover functional and evolutionary knowledge about enzymes!

[Kannan Lab ESBG @kannanlab]

Read our latest @eLife publication with @Pseudoenzyme Eyers lab! Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases by Venkat, Watterson, Byrne, et al!

https://t.co/PfcrdzRrus

[Prof Patrick Eyers @Pseudoenzyme]

Read our latest @LivUniBCSB kinase study with @kannanlab Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms https://t.co/MvAbqPD8Mb

[Kannan Lab ESBG @kannanlab]

Rayna Carter and Kennady Boyd from the Kannan lab receive summer internships to work on the NIH common fund project on "Illuminating the Druggable Genomes", Congratulations!

[Kannan Lab ESBG @kannanlab]

New publication on the prevalence of pneumococcal serine-rich repeat proteins, critical for the development of a protein vaccine. Led by Javid Aceil and Aarya Venkat in a joint collaboration with Fikri Avci at Emory!

#Bioinformatics #epidemiology

https://t.co/LPBMwL4Hvs

[Kannan Lab ESBG @kannanlab]

New preprint out on DCLK family #kinases and their unique modes of autoregulation. Joint effort led by Aarya Venkat, Grace Watterson, and Dominic Byrne. Great collaboration with @Pseudoenzyme and @ClaireEEyers!

https://t.co/7nT41zgssy

#Bioinformatics #biochemistry #AlphaFold

[Kannan Lab ESBG @kannanlab]

Leading the session at #ASBMB on Tuesday afternoon for computational biology! Will be giving a talk on protein function prediction and classification using deep learning models and knowledge graph mining.

#bioinformatics #machinelearning

[Kannan Lab ESBG @kannanlab]

Our graduate student Aarya Venkat (https://t.co/pfe5FWTBJc) gave a spotlight talk at the ASBMB conference yesterday on the evolution of glycosyltransferases! #glycotime #evolution

[Kannan Lab ESBG @kannanlab]

We have a new paper out, an explainable deep learning model for #kinase phosphosite prediction, enabling substrate predictions at the whole kinome level. #bioinformatics #MachineLearning #DeepLearning #Biochemistry

Link to paper:
https://t.co/1udsheDhyY

[Kannan Lab ESBG @kannanlab]

The second paper is on using these protein language models for embedding-based tree visualizations, orthogonal to (but consistent with) sequence-alignment based approaches. Useful for capturing relationships for difficult-to-align protein families: https://t.co/WHwobOJIiF

[Kannan Lab ESBG @kannanlab]

Two new papers out in Briefings in Bioinformatics. The first on an alignment-free approach for estimating sequence conservation using sequence embeddings made from protein language models: https://t.co/LNoP6PdlZA

#Bioinformatics #MachineLearning #AI

[Kannan Lab ESBG @kannanlab]

Proud of our undergraduate lab member, Grace Watterson, who presented an excellent talk on her work on DCLK kinases at the Harden conference in the UK.

#kinase #bioinformatics

[Kannan Lab ESBG @kannanlab]

Congratulations to our graduate student Aarya Venkat (@aaryakat) for winning a poster award for his research at the 2022 @SFGlycobiology conference!!

#glycotime

[Prof Patrick Eyers @Pseudoenzyme]

Thanks to everyone who made @BiochemSoc 88th #Harden meeting such a huge success. It was a pleasure to have so many team members and collaborators under one roof, including our newest collaborator from @kannanlab

[Kannan Lab ESBG @kannanlab]

Congratulations to our grad student Maya Salcedo for recieving the @ARCSFoundation scholarship! @ARCS_Atlanta

#biochemistry #WomenInScience

[Kannan Lab ESBG @kannanlab]

Congratulations to George Bendzunas, a postdoc in our lab, for winning first place in the poster competition at the Winship Cancer Retreat. His poster was titled "Heterodimerization Provides a Pathway for Regulation of the BRSK Dark Kinases."

#kinase #IDG #biochemistry #cancer

[Kannan Lab ESBG @kannanlab]

Congrats to Aarya Venkat @aaryakat in our lab for his recently accepted paper on the modular evolution of fold A glycosyltransferases (GT-As). Here's a neat conception of our model for GT-A evolution.

#glycotime #Bioinformatics #biochemistry

https://t.co/3CKraBEc4H

[Kannan Lab ESBG @kannanlab]

Congratulations to our lab's own Dr. Wayland Yeung for successfully defending his dissertation, titled "Traditional and representation learning approaches for protein sequence analysis."

#bioinformatics

[Prof Patrick Eyers @Pseudoenzyme]

It was another great session, thanks @CyertMartha for coming, and for the exciting talks on pseudophosphatases from @Sharpe_Lab, glycogen synthase complex from @zeqiraj and the endless possibilities of glycosyltransferases from @kannanlab

[Kannan Lab ESBG @kannanlab]

@andy___jones Aww thank you!