It annoyed us that annotation tools aren't great at saying "I just don't know". That's a real problem for metagenomes and non-model organisms, where it usually means picking some threshold and hoping for the best. We built FAMUS to try and fix this. https://t.co/s5Pusfy4G1 1/8
๐งฌ New preprint alert!
Protein language models have transformed bioinformatics, but what about the tokens they read?
In our new preprint, ๐@EllaRannon๐ studies how tokenization choices shape pLM performance and efficiency. ๐งต(1/5) https://t.co/VTmP0tcDPL
1/4 Ever wanted to predict bacterial protein-protein interactions (PPI) on a large scale?
We wanted to, but realized thereโs no such algorithm that is both rapid and optimized for bacterial protein analysis.
This led our โญ๏ธChen Agassyโญ๏ธ to develop B-PPI: https://t.co/YCAzYBiY2y
How do plasmids kickstart gene expression in new hosts?
Our new review in Plasmid: โStrategies for zygotic gene expression during plasmid establishmentโ with Nathan Fraikin (@tacc_c lab).
Part of the #ISPB2024 special issue (Hamamatsu, Japan)๐งต1/6
https://t.co/srs0gLnHmU
1/6 ๐งฌ๐ Curious about the buzz around NLP in biology? Feeling overwhelmed by the rapid developments? We've got you covered! Our review on NLP applications in genomics, by the wonderful @EllaRannon, is now out as a pre-print! #NLP#Bioinformatics https://t.co/RlNC5iq1wR
๐จNew paper alert! The amazing @EllaRannon developed DRAMMA, a machine learning model that enhances antimicrobial resistance gene detection using diverse biological data๐งฌ. Superbugs, beware! https://t.co/q7gf9vwMda
#Bioinformatics#MachineLearning#AMR 1/6
It's not very often in science that you raise a hypothesis, design an experiment and (after ups and downs, obviously) - the results actually concur! โจ
It was a pleasure and a privilege to work with the amazing @BruriaSamuel on this exciting project, now out in @Nature! ๐งฌ
Meet The Shielded Plasmid๐ก๏ธ๐งฌ
Our new @Nature paper reveals how plasmids outsmart bacterial defenses during conjugation.
It's all about being in the right place at the right time! The positioning of anti-defense genes boosts transfer efficiency๐งต(1/7) https://t.co/6n8brUx1PU
New preprint about genome editing in ladybugs!
https://t.co/JuIaaxUSgt
CRISPR/Cas9 is an excellent tool for genome editing. It makes things much more straightforward than previous technologies.
Our CRISPR journey to the @Space_Station is now out in print! ๐
Next time you take a trip to infinity and beyond, pack up some Cas12a for genetic diagnostics, we show that it might come in handy ๐.
Thanks @danalon6 and everyone involved for an amazing experience!
Why send CRISPR to space?? ๐
For diagnosis, of course!!!
Being so portable, versatile, and easy to use, CRISPR-based diagnostics is a natural candidate for genetic diagnostics during space missions!
More below, and in our recent paper:
https://t.co/byoN4SdE4f
๐งต 1/5