Inbal Zigdon

Science

[Barkai Lab @BarkaiLab]

How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? 🧬

We're excited to show you how we tackle this question in our new bioRxiv pre-print!

https://t.co/rwjTaCekCR

[Barkai Lab @BarkaiLab]

(1/8) Still wondering how low complexity intrinsically disordered regions (IDRs) guide transcription factors (TFs) to bind in genomes? Previous studies on sequence grammars; our new @MolCell paper takes the next step: de novo design of functional TF IDRs!
https://t.co/qJugw2V3qE

[Tamar Jana @tamar_jana]

Super excited to share this work! @SagieBr it was amazing time working together

[Sagie Brodsky @SagieBr]

Our new paper (and method) is out. Tell us what you think :)

As always, it has been a pleasure working with you @tamar_jana

[FJonas @FJonas15]

Read the newest chapter of the histone timer⏲️arc in our @NAR_Open paper investigating 🧐 the role of different histone chaperones and remodelers using the . Special thanks to Gilad, it was again great working with you👨‍🔬 and the other members of the @BarkaiLab👩‍👧‍👦. (🧵)

[Barkai Lab @BarkaiLab]

New @NAR paper by @FJonas15 & Gilad defining main activities of histone chaperones & chromatin remodelers in nucleosome exchange 🐣

Do they mainly incorporate nucleosomes displaced by transcription? Increase exchange in promoters to enable TF binding?

https://t.co/JhN45KDo9m

[Barkai Lab @BarkaiLab]

Excited to share our newest preprint by @TamarGera @FJonas15 & Roye More: Evolution of binding preferences among whole-genome duplicated transcription factors
https://t.co/GBQBIir4QS
Ever wondered how the transcriptional network evolves? Read more to find out! (1/7)

[Inbal Zigdon @InbalZigdon]

In case you missed my previous tweet of this amazing work from our lab @BarkaiLab @tamar_jana @SagieBr

[Sagie Brodsky @SagieBr]

For those of you who found our paper too long to read 😉 – here’s a wonderfully written spotlight that captures the essence of our work. Thank you U.S. Sandra, Arushi Shukla and @UllasKolthur. @tamar_jana @BarkaiLab @TrendsGenetics @MolecularCell

https://t.co/9yxXWplbFK

[Inbal Zigdon @InbalZigdon]

Worth reading!

[GatKrieger @GatKrieger]

Glad to share my paper with @OffirLupo @BarkaiLab is published now @genomeresearch! How does transcriptional regulation change between closely-related species? Do changes in transcript abundance must involve changes in dynamic regulation? https://t.co/Yec2qP650Q

[Aldema Sas-Chen @AldemaSasChen]

Excited to share my newly published paper on RNA acetylation in @nature. A great collaboration between the labs of @SchragaSchwartz, Moran Shalev-Benami and @doc_jlmeier, shedding genomic and structural insights into the roles of ac4c in thermoadaptation.
https://t.co/iuIoAlKyXr

[Molecular Cell @MolecularCell]

Online Now: Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity https://t.co/WrNmQ9Yfj6

[Sagie Brodsky @SagieBr]

Excited to share my latest work together with @tamar_jana published today @MolecularCell. We focused on how transcription factors that bind similar motifs in-vitro localize to distinct promoter sets in-vivo. @BarkaiLab @WeizmannScience (1/7) https://t.co/Pfmyo4Oxxb

[Inbal Zigdon @InbalZigdon]

A new role for IDRs in TFs?

[Sagie Brodsky @SagieBr]

We propose that long intrinsically disordered regions (IDRs), which are prevalent in TFs, guide in-vivo promoter selection. This solution may reduce the search time of a TF for its binding sites within large genomes (6/7)

[GatKrieger @GatKrieger]

Excited to share my first preprint! 🔥Independent evolution of transcript abundance and gene regulatory dynamics @offirlu @barkailab @biorxivpreprint How does transcription regulation changes between closely related species? A thread… https://t.co/BxCxzGhtw7