How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? 🧬
We're excited to show you how we tackle this question in our new bioRxiv pre-print!
https://t.co/rwjTaCekCR
(1/8) Still wondering how low complexity intrinsically disordered regions (IDRs) guide transcription factors (TFs) to bind in genomes? Previous studies on sequence grammars; our new @MolCell paper takes the next step: de novo design of functional TF IDRs!
https://t.co/qJugw2V3qE
Read the newest chapter of the histone timer⏲️arc in our @NAR_Open paper investigating 🧐 the role of different histone chaperones and remodelers using the . Special thanks to Gilad, it was again great working with you👨🔬 and the other members of the @BarkaiLab👩👧👦. (🧵)
New @NAR paper by @FJonas15 & Gilad defining main activities of histone chaperones & chromatin remodelers in nucleosome exchange 🐣
Do they mainly incorporate nucleosomes displaced by transcription? Increase exchange in promoters to enable TF binding?
https://t.co/JhN45KDo9m
Excited to share our newest preprint by @TamarGera@FJonas15 & Roye More: Evolution of binding preferences among whole-genome duplicated transcription factors
https://t.co/GBQBIir4QS
Ever wondered how the transcriptional network evolves? Read more to find out! (1/7)
For those of you who found our paper too long to read 😉 – here’s a wonderfully written spotlight that captures the essence of our work. Thank you U.S. Sandra, Arushi Shukla and @UllasKolthur. @tamar_jana@BarkaiLab@TrendsGenetics@MolecularCell
https://t.co/9yxXWplbFK
Glad to share my paper with @OffirLupo@BarkaiLab is published now @genomeresearch! How does transcriptional regulation change between closely-related species? Do changes in transcript abundance must involve changes in dynamic regulation? https://t.co/Yec2qP650Q
Excited to share my newly published paper on RNA acetylation in @nature. A great collaboration between the labs of @SchragaSchwartz, Moran Shalev-Benami and @doc_jlmeier, shedding genomic and structural insights into the roles of ac4c in thermoadaptation.
https://t.co/iuIoAlKyXr
Excited to share my latest work together with @tamar_jana published today @MolecularCell. We focused on how transcription factors that bind similar motifs in-vitro localize to distinct promoter sets in-vivo. @BarkaiLab@WeizmannScience (1/7) https://t.co/Pfmyo4Oxxb
We propose that long intrinsically disordered regions (IDRs), which are prevalent in TFs, guide in-vivo promoter selection. This solution may reduce the search time of a TF for its binding sites within large genomes (6/7)
Excited to share my first preprint! 🔥Independent evolution of transcript abundance and gene regulatory dynamics @offirlu @barkailab@biorxivpreprint How does transcription regulation changes between closely related species? A thread… https://t.co/BxCxzGhtw7