Offir Lupo

Evolution of gene regulation @BarkaiLab.

[Offir Lupo @OffirLupo]

Exciting new work by @SagieBr and @tamar_jana !
Using their cool new method, they show that TF binding cooperativity is, in fact, quite limited! super comprehensive and elegant work, check it out!

[Barkai Lab @BarkaiLab]

New 📄 by @tamar_jana + @SagieBr
We introduce MPBA, a novel method allowing parallel measurement of TF binding to thousands of designed DNA sequences within cells. We use it to answer a fundamental question - how prevalent is TF binding cooperativity. 1/9 https://t.co/XEMgBsRKw3

[Barkai Lab @BarkaiLab]

🎉Happy to share our new paper! Intrinsically disordered regions (IDRs) in transcription factors (TFs) encode for complex binding patterns using diverse sequence grammars and interaction types. (1/9)
https://t.co/FjPshZfYwM
@bhurieva @Divya_KKumar guided by @FJonas15 @NaamaBarkai

[Offir Lupo @OffirLupo]

Beautiful work!

[Barkai Lab @BarkaiLab]

Exciting news! Our latest paper "Ordered and disordered regions of the Origin Recognition Complex direct differential in vivo binding at distinct motif sequences", led by Michal Chappleboim is now out in @NAR_Open. Check out the highlights below.
https://t.co/e7AxBbi7rW

[Itai Yanai @ItaiYanai]

Our paper is out today in @Nature! Imagine getting this plot when studying single-cell data of growing bacteria! Could it be the cell cycle?! We found that a gene’s response to its replication reveals gene regulation on a genomic scale.
https://t.co/KQidVr6WKZ @AndrewPountain

[Offir Lupo @OffirLupo]

Exciting work by @SagieBr and @MindelVladimir, congrats!🥳

[Barkai Lab @BarkaiLab]

Check out our new paper: “Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars” published @NAR_Open. The work of @MindelVladimir and @SagieBr. https://t.co/pAvCTMpLkG

[Ran Harnevo @harnevo]

Yesterday's night i posted a video about the horrific genocide Israel experienced on Oct. 7th.

The video was removed from Twitter and my account was locked after generating over 250,000 views, and counting. It contained some truths which were too graphic for this platform...

I post it again, a softer version but still hard to watch for some (*trigger warning*). I ask you to please share it again, comment again, make the video fly again!

Let our voice be heard!
And #StandWithIsrael

[Josh Brickman @josh_brickman]

Another paradigm destroyed by @BarkaiLab - https://t.co/L8hZvHmXiJ. Previously they found DNA binding domains were not important and now #cooperativity is minimal and unidirectional. How to explain specificity? I am lost!!!! #papertunes - Iggy/the Stooges, “Search and Destroy.”

[Offir Lupo @OffirLupo]

Beautiful work by @voichek !! Congrats!🥳

[Offir Lupo @OffirLupo]

@FJonas15 @BarkaiLab @CellSystemsCP Thanks Felix!

[Offir Lupo @OffirLupo]

@nadavshai @Divya_KKumar @BarkaiLab @NaamaBarkai @WeizmannScience 🙏 thanks!

[Offir Lupo @OffirLupo]

Super happy to see the second chapter of my PhD published😍😃 Huge thanks to all co-authors: @Divya_KKumar, Rotem Livne, Michal Chappleboim, Idan levy, the rest of the wonderful @BarkaiLab members, and of course to @NaamaBarkai
@WeizmannScience

[Barkai Lab @BarkaiLab]

🔥Hot from the oven🔥! Our new paper led by @OffirLupo on the role of TF cooperativity in binding specificity is now out in @CellSystemsCP
see🧵below for highlights (1/10)

@WeizmannScience
https://t.co/qRY5xdQi4c

[Barkai Lab @BarkaiLab]

New @NAR paper by @FJonas15 & Gilad defining main activities of histone chaperones & chromatin remodelers in nucleosome exchange 🐣

Do they mainly incorporate nucleosomes displaced by transcription? Increase exchange in promoters to enable TF binding?

https://t.co/JhN45KDo9m

[Barkai Lab @BarkaiLab]

🥳🎉We are delighted to share our new paper that deciphers the complementary strategies by DNA binding domains (DBDs) and IDRs in directing transcription factor (TF) target specificity. 🎉🥳
https://t.co/SBuCQuV7rM
@Divya_KKumar
@FJonas15
@BarkaiNaama

[FJonas @FJonas15]

Proud to present our 🎉new paper🎉deciphering the IIDR grammar of transcription factor target specificity: https://t.co/Gij3ZAG7a2. Special shout out to my fellow code breakers 🕵️ @BennyKrupkin and MiriCarmi and the rest of the @BarkaiLab - follow 🧵 for highlights

[Offir Lupo @OffirLupo]

@davidle15455553 @NaturePlants @JosepPenuelas @Burriach @LivneStav Congrats David!🥳

[GMI Vienna gmivienna.bsky.social @gmivienna]

In this #PrePrint, GMI #postdoc @voichek & researchers from the Nordborg & Berger labs quantify the DNA replication state in ♂️ and ♀️ #gametes and study the #cellcycle phases during Arabidopsis reproduction 🧬🌱

➡️ https://t.co/sfuQaL3MXe

@TrainingVbc @viennabiocenter @oeaw

[Barkai Lab @BarkaiLab]

Come join us :)

[Barkai Lab @BarkaiLab]

Back 2 back @BarkaiLab papers studying chromatin in the new issue of @genomeresearch!

@FJonas15 & Gilad Yaakov follow histone exchange during replication for the first time:
https://t.co/Hg7tpKgPam

@GatKrieger & @OffirLupo probe TF binding regulation:
https://t.co/Dp3gzJy5FM

[Barkai Lab @BarkaiLab]

Our new paper on Histone Exchange during DNA replication by @fjonas15 and Gilad Yaakov will appear in the upcoming June issue of @genomeresearch !

https://t.co/Q5tr7nsaRl

[Offir Lupo @OffirLupo]

Hot from the oven 🔥🔥 our paper about evolution of transcription factor binding with the amazing @GatKrieger now out at @genomeresearch !!

[GatKrieger @GatKrieger]

Excited to share the latest paper from my PhD with @barkailab @offirlupo in collab with @twittkopp about evolution of TF binding in yeast! https://t.co/rwDXYMiHNi