Karl Pichler

Grandpa, 🇦🇹/Steyr Philosophie der Technik, Naturwissenschaften, Informatik
Sikhi ਸਿੱਖੀ ੴ
Born to be Wien

[Karl Pichler @Karl_Pichler]

Erst wenn Du jede Situation im Leben meisters, hast Du den wahren Sinn des Daseins erkannt.

[Sabine Hossenfelder @skdh]

Physicists may have found the origin of gravity. And that would finally explain why gravity is different from the other forces of nature.

[Karl Pichler @Karl_Pichler]

Ja ja da Francis Boyle

[The Vigilant Fox 🦊 @VigilantFox]

RFK Jr. says Fauci paid UNC scientist Ralph Baric to develop a technique called "no-see-em," which makes pathogens MORE dangerous and COVERS UP the evidence of human manipulation.

Baric went on to teach this technique to the "Bat Lady" at the Wuhan Lab.

Fauci knew this. Then spent years telling the public COVID came from a "natural origin."

RFK JR: "He was lying about the origins from day one. Why was he lying? Because he funded those studies at the Wuhan lab, and he funded the studies at the University of North Carolina that developed the techniques for weaponizing COVID-19."

"And then [he] gave those to Ralph Baric, his funded scientist at the University of North Carolina, gave those to Shi Zhengli, the scientist, the 'bat lady' scientist in the Wuhan lab. And he taught her a technique that Anthony Fauci had paid him to develop called seamless ligation, which is also called 'no-see-em.'"

"It's a way of manipulating the virus to make it deadly to human beings and then covering up the evidence of human manipulation."

"And why would anybody spend NIH money developing that kind of technology?"

"It's bioweapons technology. It has nothing to do with public health. It's the opposite. It's the inverse of anything you would want to do with public health."

"Well, he took that, and he gave it to the Chinese military lab at Wuhan."

Fauci’s former senior adviser David Morens has now plead guilty for conspiring to defraud America by destroying federal records during COVID.

He previously said: “Tony doesn’t want his fingerprints on origin stories.”

[Dr. Simone Gold @drsimonegold]

David Morens just pleaded guilty.

Fauci’s senior advisor. The man who sat at his right hand for years.

He used a secret Gmail account to hide official communications from the American people. He destroyed and concealed federal records to evade FOIA. He worked to protect the grants that flowed into Wuhan and the narrative that COVID could not have come from the lab his agency funded.

This was not a clerical error. This was a deliberate cover-up while the country was locked down, censored, injected, and told to “trust the science.”

Careers were destroyed. Early treatments were suppressed. Children lost years of their childhoods. Millions suffered.

We stood on the steps of the Supreme Court in 2020 and told the truth. They censored us. They called us dangerous. They were the ones deleting the evidence.

One guilty plea is not enough. The house of cards is still standing as long as the man at the top remains untouched.

Accountability is not optional. It is the only path back to medicine and a free country.

[Michael Levin @drmichaellevin]

Final version is out! #bioelectricity Patrick McMillen (https://t.co/BAl7oalrG4)

"Lifetime imaging reveals long-distance non-neural bioelectric patterns on timescales from seconds to hours"

https://t.co/StCqmltMP1

Translating the bioelectric code remains one of the core challenges to widespread biomedical translation of bioelectric interventions, as well as a better evolutionary understanding of how developmental ionic signaling evolved to become the basis of neural intelligence. To advance our understanding, it is crucial to develop model systems that allow simultaneous, quantitative study of diverse bioelectric parameters in living states, which must also be linked to cell- and tissue-level outcomes. Here, we apply quantitative Fluorescent Lifetime Imaging (FLIM) optical estimation of membrane potential (Vmemoe) to map the bioelectric dynamics of spreading Xenopus laevis neural crest explants (NCEs) over > 17 h. We identify a slow hours-scale bioelectric component and distinct faster minutes-scale and seconds-scale components. These dynamics often span multiple cells, consistent with roles in the collective behavior of NCEs. We then use information theory to show that minutes-scale NCE Vmemoe dynamics are largely distinct from calcium dynamics. Finally, we provide a survey of diverse bioelectric events revealing a deep complexity in collective bioelectric dynamics, likely involving tunneling nanotubes in their transmission, which suggests numerous avenues for further investigation. These combined data demonstrate FLIM as a powerful tool for observing subtle bioelectric signals at the large temporal and spatial scale needed for developmental biology studies.

[Brick Suit @Brick_Suit]

This skateboard trick may never be eclipsed.

Danny León, a Spanish Olympic skateboarder, set up this shot and landed it during today's eclipse in Spain.

Perfect planning!

[Nassim Nicholas Taleb @nntaleb]

Simply, most "friends" are fair-weather friends.

[WarMonitor🇺🇦🇬🇧 @WarMonitor3]

That random bus driver who removed the explosive drone with over 800 grams of Semtex at Leipzig airport just prevented a catastrophe...

[Karl Pichler @Karl_Pichler]

🐕
#WorldCatDay

[Michael Levin @drmichaellevin]

new #preprint @PigozziFederico

https://t.co/RTqAmDFqUH

"Causal Architecture Dynamics Prior to Arrival of Self-replicators in a Model of Catalytic Networks Relevant to Origin-of-Life"

We know what happens once replicators appear - systems that persist and evolve. But what's happening *before* replicators arise? Can we catch a signature of the impending future arrival of a system that will replicate itself (and thus persist, spread, etc.)? Apparently so. Check out it out. Lots of implications, I will unpack it all in a blog post coming up.

[UEFA @UEFA]

Statement on behalf of UEFA and its 55 National AssociationStatement on behalf of UEFA and its 55 National AssociationStatement on behalf of UEFA and its 55 National AssociationStatement on behalf of UEFA and its 55 National Associations

[Michael Levin @drmichaellevin]

New #preprint: @SteffiKapsetaki , Tomer Landsberger
https://t.co/H9sX3aDmtY

When planaria get exposed to barium, their heads explode and fall off. But, remarkably, they quickly grow new heads that are barium-insensitive! How does it work? Out of all the possible targets in their genome, they regulate a small number of genes which enable the heads to live in the K+ channel blocker barium. In our past paper on this (https://t.co/2kiIKP6s0I), we found out which genes, but we had sequenced all the worms as a combined batch - we didn't know if each individual worm finds the same solution in transcriptional space, or different ones. How many solutions to the barium challenge are there? What would you guess - do they all find the same solution or each one walks a different path in transcriptional space, to resolve this stressor? In this new paper, we analyze individual worms:

Abstract: "Exposure to the potassium channel blocker barium chloride (BaCl₂) causes head degeneration in Dugesia japonica flatworms, followed by regeneration of BaCl₂-insensitive heads, offering a unique model for studying transcriptional resilience to novel stress. We performed RNA sequencing on individual planaria to investigate different transcriptional solutions to the BaCl₂ challenge, and how regeneration history and social environment shape transcriptomic responses to BaCl₂. We identified a robust transcriptional strategy and a potential sub-strategy for enabling BaCl₂-insensitive head formation. Moreover, we observed pronounced transcriptional differences between untreated worms regenerating from tail fission fragments (tail-regenerated), and untreated full-sized worms that did not fission during the experiment (intact controls), highlighting the lasting impact of regeneration history. Relative to controls, tail-regenerated worms upregulated neurodevelopmental and morphogenetic programs, while downregulating mitochondrial transport and stress-response pathways. Relative to intact controls, BaCl₂-exposed regenerates upregulated ion transport, metabolic, cell cycle, and inflammatory pathways, while downregulating neuronal signaling, ion homeostasis, morphogenesis, and tissue repair programs. Comparison of BaCl₂-exposed isolated and BaCl₂-exposed group-housed worms revealed minimal transcriptional divergence between social conditions. These findings underscore the complex interplay between regeneration, chemical stress, and social context in shaping gene expression."

[Karl Pichler @Karl_Pichler]

Dieser Spruch ist stoische Weisheit ohne Anspruch auf Karma.
Das Universum ist mit einer sinnlosen, gelassenen Leere erfüllt.
Warum gibt es dieses Universum überhaupt?
Könnte es nicht doch einen kleinen sinnvollen Funken geben sich als integralen Teil mit diesem Universum zu fühl

[Karl Pichler @Karl_Pichler]

Erst wenn Du jede Situation im Leben meisters, hast Du den wahren Sinn des Daseins erkannt.

[Karl Pichler @Karl_Pichler]

Schöner Vers von
Marc Aurel
'Dies ist die Hauptsache:
Beunruhige dich nicht, denn alle Dinge entsprechen der Natur des Universums und in kurzer Zeit wirst du niemand und nirgendwo sein.'

[Karl Pichler @Karl_Pichler]

Schöner Vers von
Marc Aurel
'Dies ist die Hauptsache:
Beunruhige dich nicht, denn alle Dinge entsprechen der Natur des Universums und in kurzer Zeit wirst du niemand und nirgendwo sein.'

[Richard @ricwe123]

The Foreign Minister Abbas Araghchi:

"Egypt charges hundreds of thousands of dollars for every passage through the Suez Canal, with fees exceeding one million dollars for large container ships and tankers. Turkey imposes transit fees for vessels passing through the Bosphorus Strait. Canada charges fees for the St. Lawrence Seaway. Panama collects hundreds of thousands of dollars per transit, reaching up to 500,000 dollars for large Neo-Panamax vessels. The United States also charges fees related to the St. Lawrence Seaway.

Yet when Iran keeps the Strait of Hormuz open for free passage for decades, without imposing any transit fees, despite facing sanctions, isolation, and relentless accusations, it is portrayed as the problem.

Isn’t it hypocritical to condemn Iran while ignoring the fact that many other countries profit from controlling vital waterways? And you still expect me to believe that Iran is the ‘bad guy’ here?"

[LawZero - LoiZéro @LawZero_]

High-risk autonomous behaviours are an increasingly prevalent and dangerous reality for frontier AI models https://t.co/B0FRcTii5f

[Juez Central @Juezcentral]

Nico Williams es campeón del mundo. Y tras la premiación, va directo a la tribuna a entregarle la medalla a su madre. Ella, que en 1994 salió de Ghana y cruzó parte del Sahara para poder llegar a España en busca de nuevas oportunidades.

Una campeona más.

[Karl Pichler @Karl_Pichler]

@LouisLoujoz Bonjour Louis,J'ai interrogé Grok à propos de cette phrase d'Héraclite. Sa réponse était similaire à la vôtre. Elle établissait également une comparaison avec le yin et le yang. 🙋‍♂️

[Karl Pichler @Karl_Pichler]

Oida 🇬🇷 Heraklit

[Karl Pichler @Karl_Pichler]

Beeinflusst Karma das Schicksal.
Eine der wesentlichen Fragen

[Nassim Nicholas Taleb @nntaleb]

Vile tu uccidi un uomo morto!
Lindsey Graham is gone, he won't bother mankind any longer, no need to kill him twice. Don't be small. Have some dignity and focus on the living ones.