Secret Squirrel 🐿️

F*ck anxiety
#pyrexgate #pyrexposse

[‏ً @omgsidewalks]

“What if poor people abusė the system?”

The system intrinsically abuşes poor people. I hope this helps.

[Suzie rizzio @Suzierizzo1]

Watch the way MAGA acts when they think Martina McBride is going to be performing for 250th birthday celebration & then watch the way they react when they find out she won’t be performing because she was bamboozled into it & now they hate her. Independence Day is a DV song too.

[LK @MillerStillSuxs]

@cmclymer @MaryKeithBare1 Enjoy!

[Alleria 🇨🇦 Content Creator @alleria_eh]

How to handle a rainbow crosswalk if you encounter one:

[Biff #SARSisAirborne 🍉 @Biff234523]

🚨💊HUGE news: @US_FDA has finally granted approval to @ShionogiUS’s Xocova (Ensitrelvir), a 2nd-generation antiviral targeting SARS-CoV-2.

The approval is for the indication of “post-exposure prophylaxis of COVID-19 following contact with an individual who has COVID-19”. However, just like with any drug, it can obviously also be used off-label (e.g. treatment of both acute COVID or Long COVID).

In Japan, Xocova received Emergency Use Authorization for the treatment of acute COVID all the way back in November 2022, received full approval in March 2024, and an expansion to include post-exposure prophylaxis in March 2026.

The post-exposure prophylaxis indications are based on the SCORPIO-PEP trial (https://t.co/Dxv0lhS2CM), where Xocova reduced the incidence of COVID-19 after household exposure by 67%, from 9.0% down to 2.9%.

Mechanically, Xocova is the same class of drug as Paxlovid - a 3C-like protease inhibitor that inhibits viral replication. From our best understanding, Xocova is probably slightly more potent than Paxlovid, but the more definitive advantage is that it comes with less side effects and less drug interactions (which are caused by the Ritonavir component of Paxlovid, added to boost the concentration of the actual antiviral, Nirmatrelvir).

Xocova should be useful for lowering viral load during an acute infection, especially if taken within a couple or days of symptom onset, which may help shorten the duration of acute symptoms. Will it do anything to prevent long-term damage or the development of Long COVID? Almost certainly not, just like Paxlovid, but I’d be more inclined to tell people that it’s worth trying if we’re no longer dealing with the side effect profile of Paxlovid.

Where it makes the most sense to use Xocova, just like with Paxlovid, is as a component of polytherapy for Long COVID driven by viral persistence. The big issue there, however, is that you need a longer course of these antivirals than most physicians are willing to prescribe and/or most insurance companies are willing to cover. And they’re generally not very effective as a monotherapy, you need to pair these oral antivirals with other therapies for better coverage and tissue penetration (eg. monoclonal antibodies and Nuvaxovid, and potentially even a 2nd antiviral like Remdesivir).

All in all, this is a very important and long overdue approval. It’s not a game-changing silver bullet, and notably, nobody should really be expecting to use or rely on Xocova in a way that they wouldn’t be open to using or relying on Paxlovid in the present. But there are plenty of applications for it, and Xocova should absolutely be seen as another Swiss cheese layer / tool in the toolbox for COVID conscious community members and any allied medical providers.

[‏ً @omgsidewalks]

Ngl when I was young I thought things were bad because solutions were complicated, and now I’m older and realize things are bad because the solutions are often simple, but they would inconvenience affluent people, or those who aspire to be, and religious fanatics.

[kite 🪐 @BenusPutt]

@emkenobi

[𐌁𐌉Ᏽ 𐌕𐌉𐌌𐌉 @OrevaZSN]

In a capitalist economy, if you aren’t born into wealth, your only capital is your labor. So your body is reduced to a commodity you are forced to sell. If you can’t sell it for enough to survive and maintain yourself, you lose your only capital.

[Power to the People ☭🕊 @ProudSocialist]

Thanks to the efforts of people all over this country, nearly half of all data centers planned for 2026 have either been delayed or canceled.

Keep fighting! It’s working!

[Secret Squirrel 🐿️ @KatStew01]

Everytime I visit Florida I pray this happens to me

[Antidepressant Content @depressionlesss]

A couple eating pizza on the street when an iguana shows up, asks for a slice, gets it, and leaves happily..

[jezz @JezziiB]

Tired: Humans are killing the planet

Wired: literally like 90 specific billionaires and CEOs are killing the planet and we literally know their names

[Secret Squirrel 🐿️ @KatStew01]

@CNB_34 @ChrisJacksonSC Ft Jackson, Shaw AFB, the quarry, so many booms around here. I can't believe we still don't have a clear answer. Very strange

[Secret Squirrel 🐿️ @KatStew01]

@CNB_34 @ChrisJacksonSC This was nothing like any other boom we have had.

[☈ Chris Jackson ☈ @ChrisJacksonSC]

My buddy Ryan just sent me another video that is INSANE from inside his hanger of the loud boom felt and heard all across SC earlier today. For context he owns an aviation maintenance company at Hamilton-Owens Airport in downtown Columbia.

Check it out as the pressure wave hit the hanger door. 🤯

[Just Sayin’ 🇺🇲 ✝️ ❤️ @catmrow0]

@CrazyVibes_1 IT. WAS. AWESOME. 😎

[Crazy Vibes @CrazyVibes_1]

Dear Gen X,
I’ve been watching 80s movies and I just need to know…WHERE WERE YOUR PARENTS??
Every child was just wandering the earth unsupervised like a raccoon with house keys. Riding bikes across town at midnight, fighting ghosts, investigating murders, befriending cryptids, hacking government computers for funsies…
And the parents were ALWAYS “out of town” or “working late” while the only adult-adjacent supervision was some random 16-year-old who got dragged into the chaos.

No cell phones. No helmets. No adult supervision. Just vibes, life lessons, and several near-death experiences.

You all weren’t “raised.” You were lightly monitored feral creatures with a bike and unresolved trauma.

I’m genuinely shocked there are enough of you left to populate an entire generation.

[Maura DragonHeart 🍀🇺🇸🇮🇪🇮🇹 🌛🌝🌜💙 @maura_resister]

🤣🤣🤣

[FireFighterDev @fire_starter457]

The MAGA Republican Platform:

Protect the fetus; starve the child.
Honor the soldier; abandon the veteran.
Enrich the corporation; fleece the worker.
Quote the Bible; ignore the verses.