Kawate lab

We💙membrane proteins! Using biochem, structural bio & C.elegans to study cell-cell communication, physiology & behavior, pain sensing & more @cornellmolmed

[Kawate lab @KawateLab]

This study puts forth a mechanism by which c-terminal cleavage liberates the CAD causing the repositioning of the N terminus to promote Panx1 channel opening.

[Kawate lab @KawateLab]

Could not be more exciting to share our latest findings about the mechanism of ATP release via the Pannexin 1 ion channel! Check it out 👉 The C-terminal activating domain promotes pannexin 1 channel opening | PNAS https://t.co/LH4HN3kqhD

[Kawate lab @KawateLab]

Our structural studies revealed that when exposed, the cytoplasmic domain, dubbed the c-terminal activating domain (CAD) can compete with the N-terminus to occupy a cytosolic pocket, which forces the N-terminus to reorient into the pore.

[Kawate lab @KawateLab]

We analyzed the electrostatic free energy of the cytosolic NTD, finding a positively charged region inside the pore that could accumulate negatively charged anions like ATP. In the reoriented NTD conformation this negative region is diminished reducing accumulation of ions there.

[Kawate lab @KawateLab]

@guntherwho @CornellMolMed @KeyenceUSA Incredible addition.

[Sarah Chan (Codd) @sarahkcodd]

When nematodes become nemaTUBE holders 🪱🧪 (thanks for the nematode @korethegenius and the pun @jacqueline_ehr !)

[Kawate lab @KawateLab]

🚨🚨check it out!! We got 3D models of our C.elegans localization studies!! 🪱@sarahkcodd

[Kawate lab @KawateLab]

Happy #InternationalWomansDay!! An official welcome to our #girlslab @ktcrow11
👩‍🔬👩‍🔬👩‍🔬

[Kawate lab @KawateLab]

Congrats to our department-mates! We’ve been eagerly following this story at our @CornellMolMed seminars & so excited to see it out!

[Shi Feng凤石 @10feng]

Check out our latest paper about glutaminase filament on @NatureComms! In this paper, we used #CryoEM and light scattering to show that the filament formation of glutaminase is coupled with its activity. https://t.co/67plY4EwbH

[Cornell University Molecular Medicine @CornellMolMed]

Its #LabFeatureFriday! Head over to our LinkedIn to learn more about Graduate Student @jacqueline_ehr and her work in the @KawateLab here at @cornellvet
https://t.co/UXhzZ6zpXQ

[Kawate lab @KawateLab]

We got our Philly (fill-y lol) ! Always a pleasure to share our work with the #BPS community. Headed back to 📍Ith feeling inspired & refreshed 💆‍♀️

[Kawate lab @KawateLab]

Kawate lab is en route to #BPS2024! Let’s talk about Pannexins at Toshi’s platform session on Tuesday & @jacqueline_ehr poster presentation on Monday 🤜🤛

[Jacqueline Ehrlich @jacqueline_ehr]

Hear me out … a jewelry store that sells diamonds in the shape of your protein crystals

[Jacqueline Ehrlich @jacqueline_ehr]

Ran across this in my rotation students notes … I guess I really emphasized it🤔

[Jacqueline Ehrlich @jacqueline_ehr]

#SpookySzn

[Jacqueline Ehrlich @jacqueline_ehr]

Sometimes you have to purify proteins late on Friday night and sometimes your coworkers turn it into a pizza and dance party 🫶

[Jacqueline Ehrlich @jacqueline_ehr]

It looks like my proteins are having a meeting in the middle of my grid … a macromolecular assembly if you will

[Kawate lab @KawateLab]

@Stokes_Lab Yes!!! Great job 😁

[Kawate lab @KawateLab]

#NewProfilePic Our new logo makes its debut! Can anyone identify the membrane protein that Toshi used as his design inspiration??