Keane Lim

Interested in psychiatric genetics & neuropsychology · Own views

[Keane Lim @KeaneLim]

Our new paper out in @SchizBulletin found & replicated 4 distinct cognitive profiles in schizophrenia. Subtypes consists of a “less impaired” subtype, two “intermediate cognitive impairment” subtypes differentiated by executive function, & “globally impaired” subtype.

[Schizophrenia International Research Society @SIRSGlobal]

Managing heterogeneity of #schizophrenia using cognitive subtyping: A latent profile analysis using data from 762 patients reveals 4 distinct profiles that were stable across time and were associated with clinical outcomes. https://t.co/YifQuechjf @SchizBulletin @KeaneLim

[Keane Lim @KeaneLim]

Thank you all participants & co-authors (Jason Smucny, Deanna Barch, @maxzylam, Richard Keefe, Jimmy Lee) for being a part of this work!

[Keane Lim @KeaneLim]

Our new paper out in @SchizBulletin found & replicated 4 distinct cognitive profiles in schizophrenia. Subtypes consists of a “less impaired” subtype, two “intermediate cognitive impairment” subtypes differentiated by executive function, & “globally impaired” subtype.

[Schizophrenia International Research Society @SIRSGlobal]

Managing heterogeneity of #schizophrenia using cognitive subtyping: A latent profile analysis using data from 762 patients reveals 4 distinct profiles that were stable across time and were associated with clinical outcomes. https://t.co/YifQuechjf @SchizBulletin @KeaneLim

[Keane Lim @KeaneLim]

This 4-profile cognitive solution showed stability across time. CFA revealed cognitive profiles are better explained by distinct profiles rather than a severity continuum.

[Keane Lim @KeaneLim]

Lastly, thank you all participants & co-authors for being a part of this work!

[Keane Lim @KeaneLim]

Our new work out on @PLOSONE investigating the genetic liability of the Ultra-High Risk (UHR) psychosis state
@maxzylam Hailiang Huang, Jianjun Liu, Jimmy Lee

https://t.co/TrahgUuNlP

[Keane Lim @KeaneLim]

Caveats: The lack of association between our Asian UHR cohort with other psychiatric traits may be due to differing ancestry & sample size of the training & target datasets. Further studies are warranted for replication.

[Dr Cathryn Lewis @cathrynlewis]

#LinkUpdate
Making progress in psychiatric genetics: two new #Anxiety GWAS published
1) Million Veterans https://t.co/wPxPAlxzdj
2) #ArmySTARRS https://t.co/KZ2besWJGN
Joins two previous studies
3)
@uk_biobank
https://t.co/5lsuEWt1ZO
4) iPSYCH https://t.co/wPxPAlxzdj

[Keane Lim @KeaneLim]

"Unlike neurocognitive tasks that are less dependent on cultural specificities, social stimuli are often abstract or utilize words with meanings that are not fully equivalent across cultures" - Hajdúk et al in @SchizRes
https://t.co/24A4NxHsZe

[Toby Pillinger @tobypill]

Our new @TheLancetPsych paper examines metabolic side effects of 18 antipsychotics in the treatment of schizophrenia: a network meta-analysis of 100 RCTs and over 25,000 patients. Here’s a tour of the paper, with some unexpected results… [thread] 1/n https://t.co/PC3U54klBN

[Keane Lim @KeaneLim]

Finally, we would like to thank all our participants who participated in this study! (8/8)

[Keane Lim @KeaneLim]

Excited to share our new work on the psychometrics of social cognitive measures in an Asian schizophrenia sample.
Huge thanks to Sara-Ann Lee, Amy Pinkham, @maxzylam , Jimmy Lee for this!
Thread follows (1/8)
https://t.co/3Gd5uEQpJd

[Keane Lim @KeaneLim]

Our findings partially replicated SCOPE's where BLERT & ER40 showed best psychometrics. However, its premature to exclude tasks with poor psychometrics for further evaluation as cultural modifications/adaptations may be required (7/8)