Keasling Lab 🏳️‍🌈🏳️‍⚧️

Twitter account for the lab of UC Berkeley Professor @JayKeasling at @JBEI. Tweets by lab members 🧬

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Excited to share our latest publication in @NatureComms! We developed a PKS-based platform for the controlled biosynthesis of high-energy fuel molecules with tunable cyclopropanation patterns. Congratulations to Dr. Kevin Yin for leading this work!
https://t.co/ueKVkK6t8L

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Happy to share our new paper out in #MetabolicEngineering! We developed a strategy to tie redox activity to the growth rate of E. coli. Growth coupling enables enrichment of high-activity variants from large mutagenesis libraries for protein engineering. https://t.co/j78HKJpXY7

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Happy to share our new paper out in #MetabolicEngineering! We developed a strategy to tie redox activity to the growth rate of E. coli. Growth coupling enables enrichment of high-activity variants from large mutagenesis libraries for protein engineering. https://t.co/j78HKJpXY7

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

@SynBio1 🥖🥖🥖 when the yeast is making monoterpenes 🌹🌷🌿🌱🌼🌲🌴

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Each year, the Keasling Lab gathers in Lake Tahoe to reflect on our progress, share goals, and think collectively about where our science can have the greatest societal impact. Proud of what we accomplished together—thank you to everyone who makes this work possible!

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

We are proud to have trained many generations of scientists, educators, founders, policymakers, and more! Happy Holidays from the Keasling Lab--with a record of attendees! 🎉 May 2026 be full of scientific achievements, education, and social impact. 🧬🌎

🧐: Can you find Jay?

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Our latest manuscript, led by @PeterWinegar et al., highlights key advances in microbial terpenoid biosynthesis and how emerging technologies will drive the next generation of designed, new-to-nature molecules. Read it now: https://t.co/HKja0oHz8P

[ShihLab @LabShih]

Our lab's new paper is out!

We introduce ENTRAP-seq, a high-throughput in planta assay for multiplexed profiling of protein-coding libraries. Using ENTRAP-seq and machine learning, we discovered transcriptional regulators from ~1,500 plant viral genomes.

https://t.co/RTNWcYzXtO

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Excited to share the work of our PhD candidate, Leah Keiser. Leah engineered polyketide synthases (PKSs) to control stereochemistry. Her work provides insights into the biosynthesis of complex molecules with tunable stereocenters 👩‍🔬🧪Check it out: https://t.co/1JDjeTtVq1

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

We're excited to share FolDE, a low-N protein optimization method. In simulation, we found that FolDE is 55% more likely to identify top-1% hits than current baseline methods. FolDE is open and can be set up on a personal computer with a single command.
https://t.co/96bQi4EaTk

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

This work was led by @jacoberts in collaboration with @beneysenbach and @cathyji. It would not have been possible without funding from the United States federal government, via the NIH, NSF, DOE, and AFOSR.

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

We're excited to share FolDE, a low-N protein optimization method. In simulation, we found that FolDE is 55% more likely to identify top-1% hits than current baseline methods. FolDE is open and can be set up on a personal computer with a single command.
https://t.co/96bQi4EaTk

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

This method is now built into Foldy, our lab's open-source protein engineering platform. Other updates: Foldy uses Boltz-2x for structure prediction, runs ESM family models, and is deployable with a single command. Setup instructions: https://t.co/OsJ8wEbgvR

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Cowan and his team achieved over 3 g/L of mevalonate from formate, demonstrating bioproduction through the electrical reduction of CO2 or by lignin depolymerization. Decarbonizing manufacturing is within reach! Read more here: https://t.co/EKY4NltHXC (2/2)

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

We're thrilled to share the work by our very own PhD candidate, Aidan Cowan, on high-titer bioproduction from renewable C1 feedstocks in engineered bacteria. This work is fundamental for a sustainable bioeconomy. Read more here, live on @NatureComms (1/2): https://t.co/EKY4NltHXC

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

Cowan and his team achieved over 3 g/L of mevalonate from formate, demonstrating bioproduction through the electrical reduction of CO2 or by lignin depolymerization. Decarbonizing manufacturing is within reach! Read more here: https://t.co/EKY4NltHXC (2/2)

[Keasling Lab 🏳️‍🌈🏳️‍⚧️ @Keasling_Lab]

We're thrilled to share the work by our very own PhD candidate, Aidan Cowan, on high-titer bioproduction from renewable C1 feedstocks in engineered bacteria. This work is fundamental for a sustainable bioeconomy. Read more here, live on @NatureComms (1/2): https://t.co/EKY4NltHXC