Very happy to share our latest work in which we describe a new signaling feature of the integrated stress response kinase PKR: the formation of dynamic PKR clusters that serve as enzyme sinks that fine-tune PKR-eIF2a interactions.
https://t.co/jz7hBPCeT0
A fantastic collaboration with @FrankaVoigt. We visualize for the first time the journey of single XBP1 mRNA molecules on their way to undergo splicing.
I'm excited to share the final chapter of my PhD work, which is now published on @eLife. We discovered how Ire1's RNase specificity is regulated and leads to different mRNA processing pathways upon ER stress. Thanks to all the collaborators! #ER_literature
https://t.co/X9WvxZduPR
New paper by the Martinez Lab in @ScienceMagazine: The team has identified ANGEL2 as an RNA phosphatase affecting tRNA processing and unconventional mRNA splicing in human cells. Collab with @UZH_en@MedUni_Wien Story: https://t.co/ocew8ONyU4 Publicaton: https://t.co/Hs7h28mjxO
Our paper is out! A lot of hard work by @Kelsey_Hickey22, and a wonderful collaboration with @JswLab and @GreenLabJHMI! We identified two factors, GIGYF2 and 4EHP, that inhibit translation upon #ribosome collision! https://t.co/VQaVH1D5VW
Very excited to share the first preprint of the lab! We describe a function of cytosolic pH in the regulation of Cyclin D1 transcription during cell proliferation and cancer #Cyclin D1 #mesothelioma
This seminar serie should be a good one for those who like low-complexity proteins ;-) still not sure whether it is a good idea to call these proteins disordered, though. I would argue that cells are pretty well organized and these proteins partecipate to create order...
A project led by HHMI Investigator Jean-Laurent Casanova @RockefellerUniv is seeking to identify genetic errors that make some younger patients especially vulnerable to #COVID19 https://t.co/0Mf3FJhkh1