Koculi Lab

Ribosome assembly and Epitranscriptomics🔬🧬🧫🧪
Account managed by Koculi lab members.
Go UTEP Miners⛏

[Koculi Lab @KoculiLab]

Our lab's research on ribosome assembly and RNA modifications was recently featured on @NIGMS ' Biomedical Beat Blog!

We are tremendously grateful to NIGMS for supporting and spotlighting our research.

https://t.co/w5SElnTfYs

@UTEP @NIH @JohnsHopkinsSPH @JohnsHopkins

[Koculi Lab @KoculiLab]

We thrilled that Christian Atayde Torres, a Ph.D. student in our lab, obtained the Scholarship for Graduate Degrees in Science and Humanities Abroad from @Secihti_Mx. This scholarship will fund his doctoral studies entirely. We are very proud of him.

[Koculi Lab @KoculiLab]

Please check it out!
https://t.co/ZbLuVWqgma

[Koculi Lab @KoculiLab]

Manuel and Vanesa's paper titled "Selective Reprogramming of Ribosome Assembly and Translational Control during Bacterial Growth Phase Transitions" was published in ACS Omega. This paper shows that during stationary phase, processes involved in ribosome fidelity are downregulated

[Koculi Lab @KoculiLab]

We are thrilled that The @WelchFoundation selected to fund The Uribe and Koculi labs for the project titled: “The mRNA Chemical Grammar of Embryonic Cell State Transitions”.

[Rosa Uribe, PhD @uribelabrice]

I am humbled and excited to announce that me and Eda Koculi from UTEP have been awarded a WelchX Collaborative Grant. We are grateful to the Welch Foundation for supporting our new project. Can't wait to get started!

[Koculi Lab @KoculiLab]

Dr. Koculi had a wonderful time at the 2026 Welch Retreat. Thank you to the organizers and participants for the inspiring discussions on cutting-edge transformative science.

@WelchFoundation

[Koculi Lab @KoculiLab]

Our work on RNA modification detection using @nanopore was published in Biochemistry. We demonstrate that Ψ2608 insertion is selectively reprogrammed across alternative ribosome biogenesis routes. This reveals a new regulatory layer in ribosome assembly.
https://t.co/GgUlVTGCIK

[Koculi Lab @KoculiLab]

Please check out or most recent work on pathway-specific reprogramming of rRNA modifications and processing under stress detected with @nanopore
https://t.co/QqCM7bVmbR

[Koculi Lab @KoculiLab]

Please check our manuscript recently published in ACS Omega:
https://t.co/UEYzxnjtvh
In it, we characterize the in vitro substrates of DDX1, a human protein involved in various diseases, including cancer, and explore its catalytic regulation.

[Koculi Lab @KoculiLab]

Please check out our new preprint: Phase-Specific Antibiotic Resistance Mechanisms in an Escherichia coli B Strain (https://t.co/e91QQy5jhX). We show how E. coli reprograms its proteome to adapt rapidly to changing nutrient conditions.

[Koculi Lab @KoculiLab]

Please check out Vanessa's new preprint. Our group has identified two Zika RNA-dependent RNA polymerase by screening the natural product NCI library. The inhibitors are purpurogallin and digallic acid.

https://t.co/L8ZrQKzV29

[Koculi Lab @KoculiLab]

Luis' latest work on RNA modifications has been published in @BiochemistryACS and our artwork was selected as supplementary cover for this issue! We can simultaneously detect 10 classes of RNA modifications at a single-nucleotide resolution.
https://t.co/Ogla74JqGC
#ribosome #RNA

[Koculi Lab @KoculiLab]

Please check out this exciting opportinity for "Professor & Endowed Welch Chair in Chemistry" at UTEP!

https://t.co/EDUHmZcTFh

[Koculi Lab @KoculiLab]

Please check out Luis' latest preprint which describes techniques for simultaneous detection at single-nucleotide resolution and at a high-throughput manner of 10 different classes of RNA post-transcriptional modifications.
https://t.co/jgbQhCpsHu

[Koculi Lab @KoculiLab]

We are proud to share that The United States Patent and Trademark Office has issued the patent (US 12,195,788 B2) to Dr. Eda Koculi titled "High-throughput and single nucleotide resolution techniques for the determination of rna post-transcriptional modifications
Abstract"

[Koculi Lab @KoculiLab]

We are thrilled to share that Luis Gracia Mazuca, a Ph.D. student in the Koculi Lab, has been awarded with the Scholarship for Graduate Degrees in Science and Humanities Abroad from @Conahcyt_Mex. This incridble opportunity will empower him to further excel in his research and make significant advancement in his academic journey. We are very thankful to @Conahcyt_Mex for their support and commitment. Congratulations, Luis! We can't wait to see all that you will achieve!

[Koculi Lab @KoculiLab]

We are ecstatic to share that Vanessa Aitken, a Ph.D. student in our lab who is originally from Chile, has been awarded the Good Neighbor scholarship for the second year in a row! Way to go, Vanessa!

Estamos emocionados por compartir que Vanessa Aitken, estudiante de doctorado en nuestro laboratorio quien es originaria de Chile, ha conseguido la beca Good Neighbor por segundo año consecutivo! Felicidades, Vanessa!

[Koculi Lab @KoculiLab]

Our lab has been granted @orau's 2024 Ralph E. Powe Junior Faculty Enhancement Award, which will allow us to investigate the role of RNA modifications in breast cancer cells and search for potential novel biomarkers for this disease, which affects more than 2 million people worldwide (WHO, 2022).

A nuestro laboratorio se le ha otorgado el premio Ralph E. Powe para el desarrollo de facultad junior 2024 por parte de @orau. Éste, nos permitirá investigar el rol de las modificaciones del RNA en celulas de cáncer de mama y buscar nuevos biomarcadores para esta enfermedad, la cual afecta a mas de 2 millones de personas en el mundo (OMS, 2022).

[Koculi Lab @KoculiLab]

We are delighted to announce that Dr. Manuel Terrazas(@ManuelT16327122), a recent graduate from the Autonomous University of Ciudad Juarez (@UACJmx) has joined our lab as a postdoc! Manuel's experience in protein biochemistry and structure biology will help us unravel the enigmas of ribosomal maturation factors.

Estamos emocionados por anunciar que el Dr. Manuel Terrazas, reciente egresado de la Universidad Autónoma de Ciudad Juárez (@UACJmx) se ha unido a nuestro laboratorio como posdoc! La experiencia de Manuel en bioquímica de proteínas y biología estructural nos ayudará a descifrar los enigmas de los factores de maduración ribosomal.