Korostelev Lab

Life sciences, structural biology, ribosome

[Korostelev Lab @KorostelevLab]

All life depends on accurate translation (both intracellular & international). Using time-resolved cryo-EM, we watched ribosomes decode mRNA, aided by EF-Tu and GTP. See our animations & article (https://t.co/mFffpChFRt) on how ribosomes proofread tRNAs to make correct proteins:

[Korostelev Lab @KorostelevLab]

Thank you Israel.

[Israel Fernandez @IsraelF96135088]

Spectacular stuff from @KorostelevLab and Niko Grigorieff lab.
Identifying new kind-of-initiation factors in single particle data from lamellae of cells... technically very clever and with high biological relevance.
Congrats!
Looking forward to reading it in detail.

[Korostelev Lab @KorostelevLab]

We find that 5MP proteins promote high-fidelity initiation by binding 48S scanning complex to bypass weak start codons. We propose renaming them eIF1S (euk initiation factor 1 scanning).

Great collab w/ @grigoriefflab.bsky.social

Congrats to all authors! https://t.co/Kcc3Skh7bw

[Ruben Gonzalez @rubenlgonzalez]

The Gonzalez Lab at Columbia University is seeking a scientific leader!

Join us in a Research Scientist position, driving single-molecule, structural, and biochemical studies of translation, translational control, and other RNA-based processes.

Apply: https://t.co/84JwVnrhS1

[Korostelev Lab @KorostelevLab]

@zegarrv Thank you.

[Korostelev Lab @KorostelevLab]

GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome. GTPBP1 promotes more stringent mRNA decoding than the bona fide delivery factor eEF1A.

Congrats to Denis Susorov and collab with Pestova lab! https://t.co/XaiYul04Zg

[Korostelev Lab @KorostelevLab]

Using "in extracto cryo-EM", we visualize ribosomes in mammalian lysates, including RRL. "Hibernating" ribosomes carry proteins that protect functional centers. These include elongation factor eEF2, LARP1 implicated in mTOR signaling, eIF5A etc. https://t.co/gG2hM2G1Ax

[WilsonLab @WilsonLab2]

Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin @shuramankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… https://t.co/gDSnWPSnsA

[Korostelev Lab @KorostelevLab]

@slavicaPD @Hashemyaser4 Thank you Slavica!

[Korostelev Lab @KorostelevLab]

ROOL monomers entangle with other monomers via strand swapping to form octameric nanocages.
https://t.co/kThZa5hsMS

[Korostelev Lab @KorostelevLab]

@disney_lab Thanks Matt. RNA is amazing indeed.

[Korostelev Lab @KorostelevLab]

With our RTI colleagues Xiaobin Ling and @WenwenFang2, we report cryo-EM structures of enigmatic bacterial RNA nanocages made of long-noncoding ROOL RNAs. Octamers are held by "A-minor staples" and other interactions. Congrats Xiaobin, Dima et al!
https://t.co/kThZa5hsMS

[Korostelev Lab @KorostelevLab]

Activation of Retron-Septu for antiphage defense. Congrats @futianmin and all co-authors!
https://t.co/LqPAi2TYC9

[Ruben Gonzalez @rubenlgonzalez]

“Undermining the future of American science is not a path to accountability — it’s a path to decline.”
In a powerful new piece, my colleague Daphna Shohamy explains how canceled grants are driving young scientists out of science—and out of the country.
🔗 https://t.co/nlZKwjar3L

[WilsonLab @WilsonLab2]

In our newly published study we show that the proline-rich antimicrobial peptide (PrAMP) Bac5 has a distinct mode of interaction with the ribosome compared to other PrAMPs…https://t.co/AECODPspzg

[Eric Vallabh Minikel @cureffi]

We developed a new siRNA drug candidate for prion disease, a @broadinstitute / @RTI_UMassChan collaboration. We now have an open IND meaning FDA has given us permission to start first-in-human trials. Work remains before trials can launch. The full update: https://t.co/tmL2vIZT4z

[Mariusz Czarnocki-Cieciura @MariuszCzC]

I’m happy to share our recent manuscript in which we are structurally and biochemically investigating 3'-5' tRNA splicing ligases, including a #cryoEM structure of the five-subunit D. rerio tRNA ligase complex.
https://t.co/VtfbOrx5u5

[WilsonLab @WilsonLab2]

Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with @inada_lab and Zaher lab. Data collected at @DCI_EM.
PNAS https://t.co/qnGrbmG5ud

[UMass Chan Medical School @UMassChan]

Anastasia Khvorova, PhD, named 2025 Else Kröner Fresenius Prize for Medical Research awardee for her pioneering work in the field of RNA-based therapies: https://t.co/QDRsFKfIZe

#EKFprize25 #EKFS #ElseKrönerFreseniusStiftung #RNA #RNAtherapies @EKFStiftung @RTI_UMassChan

[Prof. Nikolai Slavov @slavov_n]

Biological systems find ingenuous solutions. Almost anything that can happen, happens.

Still, I would not have guessed a role of RNA-binding proteins on the cell surface.

The Flynn lab are boldly investigating glycoRNAs and following their leads.

[Marvin Tanenbaum @MarvinTanenbaum]

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation

https://t.co/Oyw32LlbxM