WilsonLab

Ribosomes & Translation Regulation; Antibiotics & Resistance Mechanisms; Structural Biology & Cryo-EM; University of Hamburg.

[nature @Nature]

Nature research paper: RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity

https://t.co/UNoutY6xlG

[Molecular Cell @MolecularCell]

Hypoxia-induced ribosomal RNA modifications in the peptidyl-transferase center contribute to anaerobic growth of bacteria https://t.co/7zA64YZK7D

[Tim G. J. Rudner @timrudner]

If you're a senior researcher (i.e., associate professor or more senior), and you'd consider moving to the University of Toronto to take up a Canada Impact+ Research Chair (1 million/year in funding), email me. Discretion guaranteed.

++Please share to help me spread the word!++

[rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 @buildmodels]

Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: https://t.co/oiBdEp4YTD

[Ruben Gonzalez @rubenlgonzalez]

New Biochem Soc Trans review:

eIF3 as a modular, central regulator of translation.

Authored by @ide_nicholas and Colin Echeverría Aitken, this review integrates genetic, biochemical, and structural perspectives and highlights open mechanistic questions.

https://t.co/w3IMOJmjcM

[Ruben Gonzalez @rubenlgonzalez]

Slightly overdue article highlight!

In PNAS, we use smFRET to reveal how polypeptide release factor 2 (RF2) undergoes a cascade of structural changes to catalyze polypeptide release during translation termination and ArfA-mediated ribosome rescue.

🧵⬇️
https://t.co/ABPeLVa8mO

[CARB-X @CARB_X]

@EUjamrai's “Sketching Antimicrobial Resistance” campaign is an important reminder of the power of antibiotics. Global, multi-faceted action is needed to address AMR. @CARB_X is committed to accelerating innovative projects that target the most serious, resistant bacteria.

[WilsonLab @WilsonLab2]

RNA Therapeutics Hybrid Conference https://t.co/9tLdUwN5Yc

[Nature Methods @naturemethods]

A Method to Watch: Predicting RNA structures
https://t.co/9ej7Qkg4eb

[WilsonLab @WilsonLab2]

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination | Nature Methods https://t.co/CBsyhmy3VH

[NatureStructMolBiol @NatureSMB]

New online! EMProt improves structure determination from cryo-EM maps https://t.co/yIBmXryey7

[Korostelev Lab @KorostelevLab]

GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome. GTPBP1 promotes more stringent mRNA decoding than the bona fide delivery factor eEF1A.

Congrats to Denis Susorov and collab with Pestova lab! https://t.co/XaiYul04Zg

[Sergej Djuranovic @DjuranovicLab]

Great collaboration with @CarpeRibosomam and @slavicaPD labs on using MPRAs to look into non-coding mutations.

Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes: Cell Reports Methods https://t.co/EdJG0hHMf1

[NatureStructMolBiol @NatureSMB]

New online! Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation https://t.co/EQm9ydzC4B

[Scott C Blanchard @TheBlanchardLab]

https://t.co/wmTnd9uv8x

Huge congrats to our collaborative team for their success achieving "Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale"

https://t.co/HjR3rgA6S0

An advance in experimental throughput and sensitivity that revealed unexpected results!

[Ribosome Studio @RibosomeStudio]

I'm working on this little ribosome game. You have to build a peptide as fast as you can. Prokaryotes can incorporate 20 amino acids per second. Currently, only the tRNAs work; the amino acids are next.

[David M. Sabatini @DMSabatini]

Many congratulations to @DrMartyTaylor and all the co-first authors for providing a structural understanding of how mTORC2 recognizes and phosphorylates the Akt/PKB kinase, its most famous substrate. Massive amounts of work and creativity were required to make this possible.

[Prem Kaushal PK @prem_s_kaushal]

It was a great experience to work with a wonderful team led by @ruchianand1975. 👏👏
@unescorcb @DBTIndia @rajesh_gokhale

[WilsonLab @WilsonLab2]

Saskemycin, a potent and selective antimycobacterial agent targeting a unique site on the ribosome - PubMed https://t.co/QVb0VD89Vh

[Niko McCarty. @NikoMcCarty]

Japanese researchers found a new type of archaea with the smallest known genome: 238k bases.

They live inside ocean-dwelling dinoflagellates as symbiotes. Their genome "encodes the barest minimum of proteins for its own replication." All other molecules are taken from the host.