Kotaro Hirano

| Assistant professor at University of Shizuoka 🗻 | Mechanosensitive ion channels | Stem cell biology | Muscle regeneration | Mechanobiology |

[Kotaro Hirano @KotHirano]

1/
Our paper is out in J. Biochem: how muscle stem cells (also known as muscle satellite cells) (MuSCs) sense mechanical cues through Ca²⁺ to become activated and migrate. 🧵

https://t.co/nmcx4L9f7m

[Kotaro Hirano @KotHirano]

Thank you for sharing 💪🏻

[Muscle Cell News @musclecellnews]

A new study shows that Ca2+ fluctuations through mechanosensitive ion channels act as a key regulator of Muscle satellite cells activation during muscle regeneration and may provide new insights into the role of Ca2+ influx.

Read now: https://t.co/iJ1jDCDVHC

#CalciumInflux

[Muscle Cell News @musclecellnews]

A new study shows that Ca2+ fluctuations through mechanosensitive ion channels act as a key regulator of Muscle satellite cells activation during muscle regeneration and may provide new insights into the role of Ca2+ influx.

Read now: https://t.co/iJ1jDCDVHC

#CalciumInflux

[Kotaro Hirano @KotHirano]

@MasafumiInui ありがとうございます！

[Kotaro Hirano @KotHirano]

1/
Our paper is out in J. Biochem: how muscle stem cells (also known as muscle satellite cells) (MuSCs) sense mechanical cues through Ca²⁺ to become activated and migrate. 🧵

https://t.co/nmcx4L9f7m

[Kotaro Hirano @KotHirano]

8/
Take-home: mechanosensitive Ca²⁺ signaling through PIEZO1 and TRPM7 regulates MuSC. Many thanks to all co-authors at Univ. of Shizuoka @shizu_kendai and beyond.

This cool video below shows spontaneous Ca²⁺ fluctuations in MuSCs captured by time-lapse imaging.

[Kotaro Hirano @KotHirano]

7/
PIEZO1 also drives migration. It localises to the rear of migrating cells, and Piezo1 or Trpm7 deletion slows MuSC migration ex vivo and in vivo (two-photon intravital imaging).

[Craig A. Goodman @CraigAGoodman1]

Biomechanical regulation of Ca2+ dynamics during muscle stem cell activation
https://t.co/p50i2IRd4U

[HFSP @HFSP]

Fantastic opening day at #HFSPmtg2026!
A full house in Geneva, an inspiring lecture by Erin M. Schuman (2026 HFSP Nakasone Winner), outstanding oral presentations across the life sciences: what a great start to three days of frontier science! 🧪
#sts #HFSP

[京都大学白眉センター Kyoto University Hakubi Center @HakubiProject]

#Hakubi Associate Professor Akifumi Shiomi publishes “毛利隆元急死をめぐる毒殺説の形成―赤川元保・和智誠春誅殺事件の再検討”📚🌟

▽More details▽
https://t.co/pxlvWKK00Q

#京大白眉研究者の論文発表 #KyotoUniversity

[Muscle Cell News @musclecellnews]

Scientists highlight how mechanical signals shape muscle stem cell behavior, regulating regeneration through mechanosensitive pathways.

📖 https://t.co/krmQikfOxC

[Cell Reports @CellReports]

Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death https://t.co/4wv97zkVzi

[bioRxiv Cell Biology @biorxiv_cellbio]

Expanding and Decoding the Chemistry of Phospholipid Headgroup in Eukaryotes https://t.co/o4fgrlCd1x #biorxiv_cellbio

[京都大学工学部 @Eng_Kyoto_Univ]

合成・生物化学専攻 髙橋 重成 教授が、第22回日本学術振興会賞に選ばれました。おめでとうございます🎉
https://t.co/C7tNIQVck6

[Muscle Cell News @musclecellnews]

Researchers led by Dr. Yuki Katanosaka at @okayama_uni have shown that TRPV2 #IonChannels in muscle satellite cells are crucial for skeletal muscle remodeling.

📖 Read in @cddpress: https://t.co/EMOTJ7TeMZ

[Kotaro Hirano @KotHirano]

Thank you Prof. Shintaku for the kind invitation. I will be giving a seminar tomorrow Oct 31 at Kyoto University. I hope you can join!

[Hirofumi Shintaku @LiMeNanoBioeng]

Dr. Kotaro Hirano of Univ of Shizuoka will give us a lecture on Mechanosensitive ion channels as biophysical sensors in muscle stem cells on Oct 31 at LiMe, Kyoto University.
Come and check it out.

https://t.co/xPnO2ZSzwO