Libor Macurek

Group leader @imgprague

Investigates cell cycle checkpoints, genome instability, p53, cancer

[Libor Macurek @LMacurek]

I am happy to share a new paper on MCL1 and its unexpected role in cancer metabolism that just came out in Nat Comm. Great work Wentao and Mohammed and thanks for the collaboration.
https://t.co/1C0RK44lcD

[Lukas Cermak Lab @CermakLab]

Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to @HanaSedlackova1 for the great collaboration! https://t.co/KbcRMvXICp

[Libor Macurek @LMacurek]

I am happy to share our latest paper in NAR on the role of RAD18 in directing HR to the post-replicative chromatin. Great work Matous! https://t.co/qDPgW0j23x

[Libor Macurek @LMacurek]

We are looking for a postdoc to join our team in Cancer Cell Biology lab at @imgprague to investigate how defects in cell cycle checkpoints drive tumorigenesis. Interested candidates with expertise in cell biology, 3D cultures or protein biochemistry apply: [email protected]

[Zuzana Sumbalova Koledova @KoledovaZuzana]

📢Open postdoc positions! Exciting opportunity to join my new lab at @imgprague @BIOCEV_science & dive into the role of microenvironment during tissue morphogenesis & tumorigenesis. Apply now! Biologists: https://t.co/T4j5iae1EQ Bioinformatician: https://t.co/GyNTuDojZj

[Institute of Molecular Genetics @imgprague]

Congratulations to Monika Burocziova on a recent publication @LeukemiaJnl! Mutated PPM1D protein elevates the risk of aggressive 🩸blood cancers post-radiation. Targeting this protein could be a new treatment route for radiation-induced blood disorders.
https://t.co/XnYU3gH9OF

[Libor Macurek @LMacurek]

I am happy to share our latest screen for pathogenic variants in CHEK2 in breast cancer patients recently published in Clinical Cancer Research: https://t.co/0KbZoQlfqk

[DNA Repair Articles @DNA_Repair_JC]

Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres.
https://t.co/WefG7zptjG

[Ryan Barnes @SciRy2]

Check out our new review on #telomere fragility and mitotic DNA synthesis! We summarize what's known about these phenomena and offer our thoughts on their relation ship. Proud to have this as my first co-coresponding paper with @Opreskolab! @sanjana_thosar
https://t.co/bKBphAKHL4

[Hana Sedlackova @HanaSedlackova1]

Are you interested in DNA replication, genome stability, and cancer development? A PhD position is available in our group! Come and join us at @BFUavcr @Akademie_ved_CR @brnomycity

Thank you for sharing!

More information can be found here 👇 👇
https://t.co/IiUwpWxi1n

[DNA Repair Articles @DNA_Repair_JC]

RNA-DNA hybrids prevent resection at dysfunctional telomeres.
https://t.co/tlSwXaFmM4

[DNA Repair Articles @DNA_Repair_JC]

DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism.
https://t.co/mG0v5W5Mco

[DNA Repair Articles @DNA_Repair_JC]

NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains.
https://t.co/IACUelrYf3

[DNA Repair Articles @DNA_Repair_JC]

PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1.
https://t.co/9GEpcykG6z

[DNA Repair Articles @DNA_Repair_JC]

ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen.
https://t.co/dL6iLT25Mf

[Czexpats In Science @czexpats]

We would like to invite you to the first Young PI Forum #YPIF – a joint project of @czexpats and @UniKarlova! ✨We create a space for meeting, networking, and sharing experiences among all early-career Principal Investigators working in Czechia. ℹ️👉https://t.co/0mleJE1J4z

[Libor Macurek @LMacurek]

Dear all, I am happy to share our new paper in NAR https://t.co/Nx9vqKUTQZ where we show that shelterin function at telomeres is regulated by opposing activities of ATR and PPM1D. Thanks Radka, Matous and all others for great work! Libor