Lukas Cermak Lab

We want to be there when protein is broken down and cullins are present. #ubiquitin #ubiquitin_ligases #mouse_models

[Lukas Cermak Lab @CermakLab]

Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to @HanaSedlackova1 for the great collaboration! https://t.co/KbcRMvXICp

[Hana Sedlackova @HanaSedlackova1]

📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: https://t.co/296kJoJh1M

[michele pagano @paganolab]

now published on line @CellCellPress

https://t.co/iip0h1CPvu

[Lukas Cermak Lab @CermakLab]

Huge congrats to @yadav_anoop101, @aabdirov1, and @KatarinaOndrusk for their fantastic contributions to this elegant study! @imgprague @BFUavcr @CzechAcademy #DNAreplication #CancerResearch #proteasome #ubiquitin

[Lukas Cermak Lab @CermakLab]

Excited to share our discovery: CRL4-DCAF12 regulates DNA replication by ensuring proper nascent MCM2-7 complex assembly. This prevents genome instability and diseases like cancer.🙏Big thanks to @HanaSedlackova1 for the great collaboration! https://t.co/KbcRMvXICp

[Lukas Cermak Lab @CermakLab]

CRL4-DCAF12 fine-tunes replication by degrading MCMBP, enabling proper MCM assembly and accurate replication speed. Without it? Faster forks, DNA damage, instability—and a cancer risk.

[Lukas Cermak Lab @CermakLab]

What a wonderful, inspiring, and collaborative meeting at #EMBOubiquitin2024! In 1998, I attended my first conference—same #Cavtat, same @iDikic2. Huge thanks to the organizers @YMerbl, @YKulathu, @LabJoazeiro, @polosimona1, and @EMBOevents!

[Lukas Cermak Lab @CermakLab]

Fantastic work by @NikolDibus and an excellent collaboration with Michele Pagano @paganolab and Ondrej Stepanek @AdaptiveImmuni2! Hopefully, more journals will endorse papers focused on addressing the confusion published across all levels. https://t.co/p5t9wBTgWk

[Lukas Cermak Lab @CermakLab]

🔬 Join our research team! 🎓 Explore the vital role of the proteasome in cancer cell apoptosis. 🧬Seeking passionate PhD candidates in molecular biology. https://t.co/AsQZ1jm09E 🧪#PhDPosition #CancerResearch #MolecularBiology

[michele pagano @paganolab]

Do papers improve after peer review? Only in a limited number of cases. Is it still worth the effort? Let’s eliminate the tyranny of peer review and publish only in BioRxiv. Is it too bold for @NIH to ask to use taxpayers’ money to perform research rather than enrich publishers?

[Hana Sedlackova @HanaSedlackova1]

A postdoc position is available in our lab 🔬. If you are interested in DNA replication & genome stability, please get in touch. Thank you for sharing! More information also here: https://t.co/jjvaN6oJpf

[Lukas Cermak Lab @CermakLab]

In between experiments... #freshblood

[Lukas Cermak Lab @CermakLab]

Great talk at @imgprague by Vincenzo D'Angiollella @VdangioE3lab on #neomorphic substrates and his own Cyclin F. It's always a blast to meet other Pagano lab @paganolab alumni.

[Lukas Cermak Lab @CermakLab]

@AdaptiveImmuni2 @msmtcr Myslím, že je to každým dnem zřejmější.

[Lukas Cermak Lab @CermakLab]

Keep following us :)

[Lukas Cermak Lab @CermakLab]

FBXO38 does not control PD-1 stability
https://t.co/bzPMM500Pl

[Lukas Cermak Lab @CermakLab]

First author Nikol Dibus @NikolDibus
had dedicated her doctoral life to FBXO38, so far the only CUL1-dependent substrate receptor mutated in a hereditary form of neuromuscular atrophy. I can see more great stories coming out about this unique ubiquitin ligase.

[bioRxiv @biorxivpreprint]

Matters Arising: FBXO38 does not control PD-1 stability https://t.co/rRH5XHLxD9 #bioRxiv

[michele pagano @paganolab]

SCF-FBXO38 does not control PD-1 stability

https://t.co/MmwdzQuP4J

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[Antonio Marzio @_AntonioMarzio]

🚨 📢 My lab is looking for a highly motivated Research Associate to join our team @WCMCPathology @WeillCornell ! Learn more about us at https://t.co/PepenHRJW6. Spread the word!!
https://t.co/3jx5NHIFL9 📢