Yifat Merbl lab

Associate Prof. @Weizmann Systems Immunology, Biochemical Immunology, Immunoproteomics, Proteasomes & Ubiquitin Biology Human & Translational Immunology

[Yifat Merbl lab @YMerbl]

🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology
🔗 https://t.co/YzgdM8gsON
🧵👇

[Yifat Merbl lab @YMerbl]

@jonykipnis @WeizmannScience @Sys_Immunology תודה יוני 🙏

[Yifat Merbl lab @YMerbl]

@WeizmannCanada @WeizmannScience @Nature Thank you 🙏

[Yifat Merbl lab @YMerbl]

@WeingartenShira @WeizmannScience Thank you 🙏

[Yifat Merbl lab @YMerbl]

@CancerResearch @WeizmannScience Thank you for supporting us 🙏

[Yifat Merbl lab @YMerbl]

@AGechtman @elonmusk Thank you 🙏

[Yifat Merbl lab @YMerbl]

@jonykipnis Thank you!!

[Yifat Merbl lab @YMerbl]

🙏I’m deeply humbled to be included in Nature’s 10 for 2025. Grateful to my lab members, mentors, colleagues at Weizmann, and to my family and friends for their constant support. Our journey began with a small anomaly in the proteasome, a signal that revealed an unexpected layer of immune regulation. Excited for what lies ahead and committed to translating these insights to benefit human health.

@NaturePortfolio @WeizmannScience @ERC_Research @CancerResearch @ICRFONLINE @icrf_toronto

https://t.co/SxD2LmbECO

[Yifat Merbl lab @YMerbl]

@F4s7TXZOweVxwIc https://t.co/5qcw1cMMGP

https://t.co/ZtD2pfEqbs

[Yifat Merbl lab @YMerbl]

🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology
🔗 https://t.co/YzgdM8gsON
🧵👇

[Yifat Merbl lab @YMerbl]

@roi_gazit Thanks Roi!

[Yifat Merbl lab @YMerbl]

@meshorer1 Thanks Eran 🙏

[Yifat Merbl lab @YMerbl]

@IgorUlitsky @WeizmannScience @Sys_Immunology @Nature Thank you !

[Yifat Merbl lab @YMerbl]

@Mucus_Man Congrats and well deserved 💫👏🥂

[Yifat Merbl lab @YMerbl]

Let’s not just hope — let’s act — for a future of peace and dignity for all.
Violence and hatred must end.
Humanity must lead, and science must light the way. 🙏💫🙏 https://t.co/L6cwHe33d4

[Yifat Merbl lab @YMerbl]

@KarinGoldberg5 you make me so proud! This award is so well deserved, recognizing your passion, brilliance and talent 💫🙏💫 just keep going ❤️

[Karin Goldberg @KarinGoldberg5]

I’m excited to share that I received yesterday The John F. Kennedy Prize at the Weizmann Institute of Science that is awarded for excellence in Ph.D. studies and research! What an amazing recognition for the hard work and the amazing findings we made together with the amazing mentor Yifat Merbl @YMerbl and the Merbl lab!

[Yifat Merbl lab @YMerbl]

@IdoAmitLab @Cancer_Cell @FadiSheban @TgSanPhan @CuriousKX @FlorianIngelfi1 Congrats Ido, Fadi and the team for a beautiful study! 👏🙏💫

[Yifat Merbl lab @YMerbl]

@danetteldaniels Thank you dear! Great times as always 🙏

[Yifat Merbl lab @YMerbl]

@shouval Congratulations!

[Yifat Merbl lab @YMerbl]

Humbled and honored 🫣

[Samuel Hume @DrSamuelBHume]

@YMerbl You are welcome, your paper is completely fascinating

[Samuel Hume @DrSamuelBHume]

@YMerbl You are welcome, your paper is completely fascinating

[Yifat Merbl lab @YMerbl]

Thank you for this amazing highlight of our work 🙏🙏🙏

[Samuel Hume @DrSamuelBHume]

Top 5 advances in medicine this week (🧵)

1. An untapped treasure trove of antibiotics

The proteasome breaks down proteins that are no longer needed, but it turns out that some of the peptides it produces are repurposed as antibiotics

The top hit is a peptide derived from a serine/threonine phosphatase

This peptide kills a range of bacteria, including Pseudomonas and E. coli, and stopped mice dying from sepsis just as well as a conventional antibiotic

Study: https://t.co/AJRakhYPPb

Comment: https://t.co/5do8IGdlNm